期刊
INTERNAL AND EMERGENCY MEDICINE
卷 8, 期 3, 页码 205-210出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s11739-011-0653-0
关键词
Cholestyramine; Bile acid sequestrants; Colestipol; Colesevelam
Cholestyramine is a bile acid sequestrant, like colestipol and colesevelam. These molecules are positively charged non-digestible resins that bind to bile acids in the intestine to form an insoluble complex, which is excreted in the feces. They are used mainly for the treatment of primary hypercholesterolemia and hypercholesterolemia associated with mild hypertriglyceridemia, in patients not responding to dietary treatment as well as a second line-treatment for pruritus associated with cholestatic disease, in patients with incomplete biliary obstruction. Several data indicate that modulation of bile acid homeostasis has a good clinical effect in managing diabetes mellitus and the diarrhea from bile acid malabsorption. In this review, we present the in label use and indication for these compounds, revisiting the other clinical applications that may benefit from the use of bile acid sequestrants in the near future.
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