TEC family kinases in health and disease - loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK

The Tec Kinases Itk and Rlk Regulate NKT Cell Maturation, Cytokine Production, and Survival

(2014) M. Felices et al.   JOURNAL OF IMMUNOLOGY

Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates

(2011) Julio Gomez-Rodriguez et al.   FEBS Journal

Tec family kinases: Itk signaling and the development of NKT αβ and γδ T cells

(2011) Qian Qi et al.   FEBS Journal

Tec family kinases: regulation of FcεRI-mediated mast-cell activation

(2011) Wilfried Ellmeier et al.   FEBS Journal

The ITK-SYK Fusion Oncogene Induces a T-Cell Lymphoproliferative Disease in Mice Mimicking Human Disease

(2010) C. Dierks et al.   CANCER RESEARCH

Itk inhibitors: a patent review

(2010) Ho Yin Lo   EXPERT OPINION ON THERAPEUTIC PATENTS

IL-2-inducible T-cell kinase deficiency: clinical presentation and therapeutic approach

(2010) P. Stepensky et al.   HAEMATOLOGICA

Locus category based analysis of a large genome-wide association study of rheumatoid arthritis

(2010) Jan Freudenberg et al.   HUMAN MOLECULAR GENETICS

The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma

(2010) Konstanze Pechloff et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells

(2010) Michael A Weinreich et al.   NATURE IMMUNOLOGY

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

(2010) L. A. Honigberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-Cell Signaling Regulated by the Tec Family Kinase, Itk

(2010) A. H. Andreotti et al.   Cold Spring Harbor Perspectives in Biology

Primary B Cell Immunodeficiencies: Comparisons and Contrasts

(2009) Mary Ellen Conley et al.   Annual Review of Immunology

Proteasome inhibitors block HIV-1 replication by affecting both cellular and viral targets

(2009) Liang Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphatidylinositol-3-kinase-dependent phosphorylation of SLP-76 by the lymphoma-associated ITK-SYK fusion-protein

(2009) Alamdar Hussain et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells

(2009) K Blomberg et al.   BMC GENOMICS

Subcutaneous immunoglobulin: opportunities and outlook

(2009) S. Misbah et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

ITK Inhibitors in Inflammation and Immune-Mediated Disorders

(2009) Nisebita Sahu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Clinical development of novel proteasome inhibitors for cancer treatment

(2009) Huanjie Yang et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Autoinhibition and adapter function of Syk

(2009) Yogesh Kulathu et al.   IMMUNOLOGICAL REVIEWS

Bruton’s tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain

(2009) Abdalla J. Mohamed et al.   IMMUNOLOGICAL REVIEWS

Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk

(2009) Julie A. Readinger et al.   IMMUNOLOGICAL REVIEWS

The Lymphoma-associated Fusion Tyrosine Kinase ITK-SYK Requires Pleckstrin Homology Domain-mediated Membrane Localization for Activation and Cellular Transformation

(2009) Sue Rigby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Girls homozygous for an IL-2–inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation

(2009) Kirsten Huck et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteasome-dependent autoregulation of Bruton tyrosine kinase (Btk) promoter via NF- B

(2008) L. Yu et al.   BLOOD

Selective targeting of ITK blocks multiple steps of HIV replication

(2008) J. A. Readinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells

(2008) J. Raberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome wide analysis of pathogenic SH2 domain mutations

(2008) Ilkka Lappalainen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Identification of novel non-pathogenic mutation in SH3 domain of Btk in an XLA patient

(2007) Rebeca Pérez de Diego et al.   MOLECULAR IMMUNOLOGY