Review
Biochemistry & Molecular Biology
A. Katharina Ceranski, Martha J. J. Carreno-Gonzalez, Anna C. C. Ehlers, Maria Vittoria Colombo, Florencia Cidre-Aranaz, Thomas G. P. Gruenewald
Summary: Hypoxia develops in solid tumors and Ewing sarcoma (EwS) due to low oxygen tension. Hypoxia inducible factor 1 subunit alpha (HIF-1-a) and EWSR1::FLI1 have been identified as key molecules in the hypoxic response and oncogenesis of EwS. This review summarizes recent findings on the role of hypoxia and HIFs in EwS, suggesting their potential clinical relevance as prognostic markers and therapeutic targets in EwS treatment.
Article
Biochemistry & Molecular Biology
Gaelan Melanson, Antonia C. Du Bois, Caroline Webster, James Uniacke
Summary: In hypoxia and interferon-induced cells, ISG15 and HIFs regulate each other, altering HIF transcriptional programmes and increasing the translation activity of HIF-2alpha.
Article
Multidisciplinary Sciences
Yangdong Wu, Qingyan Kou, Lin Sun, Xiao Hu
Summary: This study identified PLAU, LDHA, and PKM as key genes involved in pancreatic cancer hypoxia and established a prognostic model that accurately predicted postrain in pancreatic cancer patients with hypoxia and immune infiltration.
SCIENTIFIC REPORTS
(2023)
Article
Toxicology
S. G. Rudyak, L. A. Usakin, E. A. Tverye, E. D. Robertson, A. A. Panteleyev
Summary: Aryl hydrocarbon receptor (AhR) expression and stability are influenced by AhR ligands. Treatment with TCDD, FICZ, and I3C caused a decrease in AhR expression. AhR degradation is regulated by proteasomal degradation and the presence of AhR antagonists, and requires the involvement of AhR dimerization partner ARNT. In addition, HDAC inhibition enhances AhR expression.
TOXICOLOGY LETTERS
(2023)
Article
Biology
Kelsie R. S. Doering, Xuanjin Cheng, Luke Milburn, Ramesh Ratnappan, Arjumand Ghazi, Dana L. Miller, Stefan Taubert
Summary: NHR-49, a nuclear hormone receptor in Caenorhabditis elegans, regulates a hypoxia response pathway that acts in parallel with HIF-1. In hypoxia, NHR-49 regulates a set of genes independent of HIF-1, including autophagy genes that promote hypoxia survival. NHR-67 acts as a negative regulator and HPK-1 acts as a positive regulator of the NHR-49 pathway.
Article
Biochemistry & Molecular Biology
Yong Zhang, Li Jiang, Nianqun Qin, Mi Cao, Xiujuan Liang, Rensheng Wang
Summary: This study reveals that under hypoxic conditions, hCINAP regulates the migration and EMT of cervical cancer cells through the Akt-mTOR signaling pathway, while also inhibiting hypoxia-induced p53-dependent apoptosis. This suggests that hCINAP may play essential roles in cervical cancer metastasis and could be a potential target for the treatment of cervical cancer.
BIOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Jenilee Dawn Woodfield, Atul Bhardwaj, Cody Bergman, Frank Wuest
Summary: Eleven small-molecular-weight compounds and three cyclic peptides were synthesized and evaluated for their binding to HIF-1α. Peptide [F-19]SFB-link-c-(Ppg)LLFVY 3 and small-molecule inhibitor 5 showed potent binding to HIF-1α, with K-D values of 0.46 +/- 0.2 μM and 7.8 +/- 3.4 μM, respectively. Both compounds are novel HIF-1α targeting compounds predicted to interact with the PAS-B region of HIF-1α, as confirmed by molecular docking studies. Lead structures 3 and 5 were further radiolabelled with fluorine-18 for in vivo PET imaging targeting HIF-1α.
Article
Fisheries
Jian-sheng Huang, Eric Amenyogbe, Lin-tong Yang, Zhong-liang Wang, Gang Chen, Wei-zheng Wang, Jian-dong Zhang
Summary: Hypoxia refers to the lack of oxygen required by living organisms to meet their metabolic needs. The expression patterns of hif-1a and related genes in response to hypoxic stress are tissue-specific and play an important role in cobia's response to hypoxia. The key regulator of the hypoxia response, hif-1a, was identified and cloned from cobia, and its expression levels in various tissues were determined.
AQUACULTURE INTERNATIONAL
(2022)
Article
Cell Biology
Francesca Ferrante, Benedetto Daniele Giaimo, Tobias Friedrich, Toshiya Sugino, Daniel Mertens, Sabrina Kugler, Bernd Martin Gahr, Steffen Just, Leiling Pan, Marek Bartkuhn, Michael Potente, Franz Oswald, Tilman Borggrefe
Summary: Notch signaling is crucial in tumorigenesis and its response is regulated by the hydroxylation and deubiquitination of NICD, which is disrupted under hypoxic conditions.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Diego Rodriguez, Deepika Watts, Diana Gaete, Sundary Sormendi, Ben Wielockx
Summary: The vascular network is crucial for sensing oxygen levels and hypoxia triggers a cascade of cellular signals, including angiogenesis, regulated by transcription factors such as HIFs and oxygen sensors like PHDs. Understanding how vascular cells respond to hypoxia under varying conditions is important for potential therapeutic targets in vascular dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Christalle C. T. Chow, Minoru Kobayashi, Gouki Kambe, Hiroshi Harada
Summary: The cellular response to hypoxia is controlled by a transcription factor called hypoxia-inducible factor 1 (HIF-1). A novel factor, zinc finger and BTB domain-containing protein 2 (ZBTB2), has been found to enhance the expression of certain HIF-1 target genes under hypoxia. ZBTB2 is recruited to the vicinity of hypoxia-responsive element (HREs) on a subset of HIF-1 target gene loci and is required for their full expression under hypoxia.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Review
Oncology
Ilias Mylonis, Georgia Chachami, George Simos
Summary: Hypoxia inducible transcription factors (HIFs) play a critical role in enabling cancer cells to thrive in low oxygen conditions. Inhibiting HIFs can prevent cancer cell growth and metastasis, with peptide HIF inhibitors showing potential as highly selective therapeutic agents. This review highlights the importance of targeting HIFs in cancer treatment and the promising development of peptide inhibitors.
Article
Multidisciplinary Sciences
Tatsuya Sato, Nobutoshi Ichise, Takeshi Kobayashi, Hiroyori Fusagawa, Hiroya Yamazaki, Taiki Kudo, Noritsugu Tohse
Summary: The initiation of heartbeat in the heart primordium leads to changes in metabolic characteristics, including increased ATP levels and decreased reduced glutathione levels. Glycolysis and ATP synthesis-linked mitochondrial respiration are enhanced, but subunits in complexes of mitochondrial oxidative phosphorylation are not upregulated. HIF-1 alpha is activated and related enzymes in metabolic pathways are upregulated to meet the increased energy demand in the heart primordium.
SCIENTIFIC REPORTS
(2022)
Review
Biology
Maria Fedotova, Ekaterina Barysheva, Olga Bushueva
Summary: Uterine fibroids are common benign tumors in women that can cause troubling symptoms and infertility. This study explores the role of hypoxia-induced factor (HIF) in the development of uterine fibroids, and finds increased expression of HIFs and downstream factors in uterine fibroid samples. The findings suggest that HIF plays a significant role in uterine fibroids, leading to further research for new prognostic markers and effective medications against this condition.
Review
Biochemistry & Molecular Biology
Marta Domenech, Ainhoa Hernandez, Andrea Plaja, Eva Martinez-Balibrea, Carmen Balana
Summary: Glioblastoma is the most aggressive form of brain tumor in adults, with hypoxia-induced factor 1 (HIF-1) serving as an important driver of tumor progression by promoting angiogenesis, immunosuppression, and metabolic reprogramming. HIF-1 is not only regulated by oxygen levels but also by various oncogenic signaling pathways, and inhibiting the hypoxia pathway could be a crucial treatment alternative for GB patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)