Hypoxia Pathway Proteins and Their Impact on the Blood Vasculature

HIF2α is a Direct Regulator of Neutrophil Motility

(2021) Sundary Sormendi et al.   BLOOD

HIF-Prolyl Hydroxylase Domain Proteins (PHDs) in Cancer—Potential Targets for Anti-Tumor Therapy?

(2021) Diana Gaete et al.   Cancers

Targeting the HIF2–VEGF axis in renal cell carcinoma

(2020) Toni K. Choueiri et al.   NATURE MEDICINE

Actively Targeted Nanodelivery of Echinomycin Induces Autophagy-Mediated Death in Chemoresistant Pancreatic Cancer In Vivo

(2020) Alexandra Thomas et al.   Cancers

Sema4D expression and secretion are increased by HIF-1α and inhibit osteogenesis in bone metastases of lung cancer

(2019) Wu-gui Chen et al.   CLINICAL & EXPERIMENTAL METASTASIS

Hypoxia Pathway Proteins in Normal and Malignant Hematopoiesis

(2019) Ben Wielockx et al.   Cells

HIF Inhibitors: Status of Current Clinical Development

(2019) Jaleh Fallah et al.   Current Oncology Reports

Weibel-Palade Bodies Orchestrate Pericytes During Angiogenesis

(2019) Mélissande Cossutta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Salinomycin inhibits breast cancer progression via targeting HIF-1α/VEGF mediated tumor angiogenesis in vitro and in vivo

(2019) Jayant Dewangan et al.   BIOCHEMICAL PHARMACOLOGY

AT-533, a novel Hsp90 inhibitor, inhibits breast cancer growth and HIF-1α/VEGF/VEGFR-2-mediated angiogenesis in vitro and in vivo

(2019) Peng-Chao Zhang et al.   BIOCHEMICAL PHARMACOLOGY

SN-38 Acts as a Radiosensitizer for Colorectal Cancer by Inhibiting the Radiation-induced Up-regulation of HIF-1α

(2018) TAKAYUKI OKUNO et al.   ANTICANCER RESEARCH

A HIF–LIMD1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia

(2018) Daniel E Foxler et al.   EMBO Molecular Medicine

Attenuation of TGFBR2 expression and tumour progression in prostate cancer involve diverse hypoxia-regulated pathways

(2018) Hui Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Differential but Complementary HIF1α and HIF2α Transcriptional Regulation

(2018) Nicholas L. Downes et al.   MOLECULAR THERAPY

The hypoxic tumour microenvironment

(2018) Varvara Petrova et al.   Oncogenesis

Sema4A responds to hypoxia and is involved in breast cancer progression

(2018) Xiao Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Hematopoietic hypoxia-inducible factor 2α deficiency ameliorates pathological retinal neovascularization via modulation of endothelial cell apoptosis

(2018) Irina Korovina et al.   FASEB JOURNAL

Inflammation and Hypoxia: HIF and PHD Isoform Selectivity

(2018) Emily R. Watts et al.   TRENDS IN MOLECULAR MEDICINE

Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy

(2018) Jingbiao Wu et al.   OncoTargets and Therapy

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation

(2017) Jongshin Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks

(2017) Mircea Ivan et al.   MOLECULAR CELL

The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth

(2017) Hyun Seung Ban et al.   Cell Death & Disease

Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish

(2017) Claudia Gerri et al.   Nature Communications

VEGF-A121a binding to Neuropilins – A concept revisited

(2017) Sarvenaz Sarabipour et al.   Cell Adhesion & Migration

Hypoxia impairs agonist-induced integrin αIIbβ3 activation and platelet aggregation

(2017) Klytaimnistra Kiouptsi et al.   Scientific Reports

HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy

(2017) Antonella Mangraviti et al.   Scientific Reports

Identification of HIF-2α-regulated genes that play a role in human microvascular endothelial sprouting during prolonged hypoxia in vitro

(2016) Tessa D. Nauta et al.   ANGIOGENESIS

The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis

(2016) W. Liang et al.   Cancer Immunology Research

Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis

(2015) Ke Yuan et al.   AMERICAN JOURNAL OF PATHOLOGY

A Lactate-Induced Response to Hypoxia

(2015) Dong Chul Lee et al.   CELL

The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1α expression in human endothelial cells through a negative feedback loop

(2015) Sylwia Bartoszewska et al.   FASEB JOURNAL

Factor-inhibiting HIF-1 (FIH-1) is required for human vascular endothelial cell survival

(2015) Serafim Kiriakidis et al.   FASEB JOURNAL

HIF-1 at the crossroads of hypoxia, inflammation, and cancer

(2015) Kuppusamy Balamurugan   INTERNATIONAL JOURNAL OF CANCER

Cellular and molecular mechanisms of inflammation-induced angiogenesis

(2015) Agata Szade et al.   IUBMB LIFE

Genome-wide analysis revealsNRP1as a direct HIF1α-E2F7 target in the regulation of motorneuron guidancein vivo

(2015) Alain de Bruin et al.   NUCLEIC ACIDS RESEARCH

Hypoxia Enhances Proliferation of Human Adipose-Derived Stem Cells via HIF-1ɑ Activation

(2015) Natsuko Kakudo et al.   PLoS One

Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability

(2015) Mi Hee Park et al.   Oncotarget

Vascular Endothelial Growth Factor Signaling in Hypoxia and Inflammation

(2014) S. Ramakrishnan et al.   Journal of Neuroimmune Pharmacology

Chronic hypoxia induces the activation of the Wnt/β-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1ΔE9 transgenic mice in vivo

(2014) Lorena Varela-Nallar et al.   Frontiers in Cellular Neuroscience

Eosinophils and Cancer

(2014) B. P. Davis et al.   Cancer Immunology Research

Hypoxia Induces Netrin-1 and Unc5b in Atherosclerotic Plaques

(2013) Bhama Ramkhelawon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Erythrocytosis: the HIF pathway in control

(2013) K. Franke et al.   BLOOD

Hypoxia and HIFs in regulating the development of the hematopoietic system

(2013) Parisa Imanirad et al.   BLOOD CELLS MOLECULES AND DISEASES

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities

(2013) Shuang Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase/Akt and Promote Angiogenesis

(2013) Guo-Xiang Ruan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolyl Hydroxylase Domain Protein 2 (PHD2) Binds a Pro-Xaa-Leu-Glu Motif, Linking It to the Heat Shock Protein 90 Pathway

(2013) Daisheng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Selectively Disrupts Brain Microvascular Endothelial Tight Junction Complexes Through a Hypoxia-Inducible Factor-1 (HIF-1) Dependent Mechanism

(2013) Sabrina Engelhardt et al.   JOURNAL OF CELLULAR PHYSIOLOGY

RUNX3 inhibits hypoxia-inducible factor-1α protein stability by interacting with prolyl hydroxylases in gastric cancer cells

(2013) S H Lee et al.   ONCOGENE

B Cells Promote Tumor Progression via STAT3 Regulated-Angiogenesis

(2013) Chunmei Yang et al.   PLoS One

Notch-1 Signaling Regulates Microglia Activation via NF-κB Pathway after Hypoxic Exposure In Vivo and In Vitro

(2013) Linli Yao et al.   PLoS One

HIF1α is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo

(2013) Parisa Imanirad et al.   Stem Cell Research

Human Placental Expression of SLIT/ROBO Signaling Cues: Effects of Preeclampsia and Hypoxia1

(2012) Wu-Xiang Liao et al.   BIOLOGY OF REPRODUCTION

Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success

(2012) Cristina Branco-Price et al.   CANCER CELL

Vasohibin induces prolyl hydroxylase-mediated degradation of hypoxia-inducible factor-1α in human umbilical vein endothelial cells

(2012) Tomohiro Kozako et al.   FEBS LETTERS

Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes

(2012) Nicolas Skuli et al.   JOURNAL OF CLINICAL INVESTIGATION

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity

(2012) Daniel E. Foxler et al.   NATURE CELL BIOLOGY

Hypoxia-Induced Alternative Splicing in Endothelial Cells

(2012) Julia E. Weigand et al.   PLoS One

Vasculogenic Mimicry of HT1080 Tumour Cells In Vivo: Critical Role of HIF-1α-Neuropilin-1 Axis

(2012) Roli M. Misra et al.   PLoS One

Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-  signaling

(2012) H. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone Morphogenetic Protein Endothelial Cell Precursor–Derived Regulator Regulates Retinal Angiogenesis In Vivo in a Mouse Model of Oxygen-Induced Retinopathy

(2011) Isabel Moreno-Miralles et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: Implications in degenerative disc disease

(2011) Akihiko Hiyama et al.   ARTHRITIS AND RHEUMATISM

CITED2 controls the hypoxic signaling by snatching p300 from the two distinct activation domains of HIF-1α

(2011) Haejin Yoon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

FGF-dependent regulation of VEGF receptor 2 expression in mice

(2011) Masahiro Murakami et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiogenesis

(2011) D. R. Senger et al.   Cold Spring Harbor Perspectives in Biology

Hypoxia induces tumor and endothelial cell migration in a Semaphorin 3F- and VEGF-dependent manner via transcriptional repression of their common receptor Neuropilin 2

(2011) Silvia Coma et al.   Cell Adhesion & Migration

From Vessel Sprouting to Normalization

(2010) Cathy Coulon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in vitro

(2010) Fei Tian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A prospective phase II study of 2-methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors

(2010) Matthew H. Kulke et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Notch3 Is Critical for Proper Angiogenesis and Mural Cell Investment

(2010) Hua Liu et al.   CIRCULATION RESEARCH

Hypoxia-driven angiogenesis: role of tip cells and extracellular matrix scaffolding

(2010) Stéphane Germain et al.   CURRENT OPINION IN HEMATOLOGY

Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-β-dependent mechanisms

(2010) Bryan L. Copple   LIVER INTERNATIONAL

Morphological and molecular aspects of physiological vascular morphogenesis

(2009) Domenico Ribatti et al.   ANGIOGENESIS

Mechanisms of Vessel Branching

(2009) Frederik De Smet et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sp1 mediate hypoxia induced ephrinB2 expression via a hypoxia-inducible factor independent mechanism

(2009) Marcus Sohl et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis

(2009) Hiroshi Kimura et al.   BLOOD

Endothelial deletion of hypoxia-inducible factor-2  (HIF-2 ) alters vascular function and tumor angiogenesis

(2009) N. Skuli et al.   BLOOD

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Cellular and Molecular Mechanisms of Vascular Lumen Formation

(2009) M. Luisa Iruela-Arispe et al.   DEVELOPMENTAL CELL

The Molecular Basis of Vascular Lumen Formation in the Developing Mouse Aorta

(2009) Boris Strilić et al.   DEVELOPMENTAL CELL

HIF-1 in the inflammatory microenvironment

(2009) Nathalie Dehne et al.   EXPERIMENTAL CELL RESEARCH

Hypoxia-inducible Factor-1-mediated Regulation of Semaphorin 4D Affects Tumor Growth and Vascularity

(2009) Qiangming Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia

(2009) Peter Rosenberger et al.   NATURE IMMUNOLOGY

Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way

(2009) Peter Carmeliet et al.   Nature Reviews Clinical Oncology

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia

(2009) Yair Benita et al.   NUCLEIC ACIDS RESEARCH

Vascular Extracellular Matrix and Arterial Mechanics

(2009) Jessica E. Wagenseil et al.   PHYSIOLOGICAL REVIEWS

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia. Regulation of NFκB signalling during inflammation: the role of hydroxylases

(2009) Kathryn M Oliver et al.   ARTHRITIS RESEARCH & THERAPY

Wnt/Frizzled signaling in angiogenesis

(2008) Marielba Zerlin et al.   ANGIOGENESIS

Hypoxia-Inducible Factor-1  Obstructs a Wnt Signaling Pathway by Inhibiting the hARD1-Mediated Activation of  -Catenin

(2008) J.-H. Lim et al.   CANCER RESEARCH

Tumor Hypoxia Blocks Wnt Processing and Secretion through the Induction of Endoplasmic Reticulum Stress

(2008) M. Verras et al.   MOLECULAR AND CELLULAR BIOLOGY

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

(2008) Tuomas Tammela et al.   NATURE

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

(2008) Pipsa Saharinen et al.   NATURE CELL BIOLOGY

Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice

(2008) E B Rankin et al.   ONCOGENE

FGF2 Translationally Induced by Hypoxia Is Involved in Negative and Positive Feedback Loops with HIF-1α

(2008) Caroline Conte et al.   PLoS One

mAKAP Compartmentalizes Oxygen-Dependent Control of HIF-1 

(2008) W. Wong et al.   Science Signaling