Article
Oncology
Reem Khaled M. E. Alsayed, Abdul Q. Khan, Fareed Ahmad, Abdul Wahid Ansari, Majid Ali Alam, Jorg Buddenkotte, Martin Steinhoff, Shahab Uddin, Aamir Ahmad
Summary: The signaling involving chemokine receptor CXCR4 and its ligand SDF-1/CXL12 has been studied in relation to cancer progression and pathogenesis, with evidence supporting its diagnostic and prognostic importance. Epigenetic regulation, including non-coding RNAs and methylation/acetylation, plays a key role in the upregulation of CXCR4 in primary and metastatic cancers.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Orthopedics
Junlang Zhu, Yamei Liu, Chen Chen, Hongtai Chen, Jiewen Huang, Yiwen Luo, Kewei Zhao, Dongfeng Chen, Zhiming Xu, Wangyang Li, Xunchao Zhang, Yunpu Xiong, Liangliang Xu, Bin Wang
Summary: The research shows that Cyasterone can enhance the migration and osteogenesis capacities of MSCs, resulting in accelerated bone fracture healing.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Oncology
Soon A. Park, Hye Rim Han, Stephen Ahn, Chung Heon Ryu, Sin-Soo Jeun
Summary: This study examined the synergistic effect of valproic acid (VPA) in enhancing MSC-delivered TRAIL efficacy, as well as the induced tumor tropism of MSCs. Combination treatment with VPA and MSCs-TRAIL increased therapeutic effect against glioma by enhancing death receptor 5 and caspase activation. Migration assays showed increased MSC migration in glioma cells and tumor site in glioma-bearing mice when treated with VPA and MSCs-TRAIL. In vivo experiments demonstrated greater therapeutic efficacy when MSC-based TRAIL gene delivery was used in VPA-treated tumors compared to each agent alone.
Review
Biochemistry & Molecular Biology
Farzad Sadri, Zohreh Rezaei, Mohammad Fereidouni
Summary: This review summarizes the molecular signature of the SDF-1/CXCR4 pathway and explains how this axis is involved in normal events.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Hala M. ElBadre, Sahar E. M. El-Deek, Haidi Karam-Allah Ramadan, Mohamed M. Elbadr, Dina Sabry, Noran M. Ahmed, Amr M. Ahmed, Reham El-Mahdy
Summary: In this study, the effects of umbilical cord mesenchymal stem cells (UC-MSCs) derived exosomes on HepG2 cell line and the underlying mechanism of controlling hepatocellular carcinoma (HCC) proliferation were investigated. The results showed that treatment with exosomes significantly reduced the survival of HepG2 cells and altered the expression levels of SIRT-1, SDF-1, CXCR-4, TNF-α, and caspase-3. Furthermore, the anti-proliferative, apoptotic, and anti-angiogenic effects of exosomes on HepG2 cells were time-dependent. These findings suggest that exosomes could be a potential novel therapy for HCC, but further large-scale studies are needed to confirm this conclusion.
Article
Materials Science, Multidisciplinary
Zhaoqi Sun, Chao Lin, Kailiu Wu, Mingyi Wang
Summary: Overexpression of SDF-1 gene promotes the homing of endogenous osteoblasts, while the combination of MCPC and LentiSDF-1 facilitates robust in situ bone regeneration by recruiting endogenous BMSCs and enhancing homing cell differentiation. This advanced design combines gene therapy and osteoinductive tissue scaffolds to achieve promising clinical bone repair efficacy.
MATERIALS & DESIGN
(2021)
Article
Oncology
Qiuzhi Gao, Linjing Cui, Chao Huang, Zhihong Chen, Xin Wang, Shaodi Wen, Yuanyuan Zhao, Mei Wang, Bo Shen, Wei Zhu
Summary: CD276 has been studied in various cancers and diseases, but its regulatory mechanisms in gastric cancer remain unclear. Mesenchymal stem cells (MSCs), important members of the tumor microenvironment, play a significant role in tumor occurrence, development, and metastasis. However, the relationship between gastric cancer mesenchymal stem cells (GCMSCs) and CD276 needs further exploration. This study found that GCMSCs up-regulated the expression of CD276 in gastric cell lines to promote tumor migration, providing a new basis for the treatment of gastric cancer.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Engineering, Biomedical
Fan An, Zhijie Hou, Xiaochao Wang, Zhongmin Wang, Chenying Jing, Ran Sui, Yameng Wu, Yunfeng Ma, Cheng Chang, Shuai Liu, Manman Li, Lijie Sun, Ziqi Gao, Wenjuan Zhang, Zhenghui Lang, Jiaqi Zhao, Yueyang Qu, Lingzhi Xu, Yong Luo, Jinsong Yan, Yuesheng Wang, Jie Xu, Quentin Liu
Summary: Mesenchymal stem cells (MSCs) play a critical role in promoting tumor metastasis, particularly in breast cancer. Through the use of a microfluidic-based 3D co-culture device, it was observed that MSCs guide cancer cell migration and accelerate invasion in a hypoxic microenvironment. The upregulation of H19 under hypoxic conditions was found to be important in MSCs-mediated cancer cell invasion. Aspirin was shown to suppress H19 expression and inhibit MSCs infiltration, leading to reduced breast cancer cell invasion.
Article
Biochemistry & Molecular Biology
Issei Shinohara, Masanori Tsubosaka, Masakazu Toya, Max L. Lee, Junichi Kushioka, Masatoshi Murayama, Qi Gao, Xueping Li, Ning Zhang, Simon Kwoon-Ho Chow, Tomoyuki Matsumoto, Ryosuke Kuroda, Stuart B. Goodman
Summary: Local cell therapy using mesenchymal stem cells (MSCs) has gained attention for treating joint diseases and fractures. This study investigated the utility of C-C motif chemokine ligand 2 (CCL2) as a therapeutic target for this therapy. The results showed that overexpression of CCL2 promoted macrophage chemotaxis and osteogenesis, as well as angiogenesis, through crosstalk between MSCs and macrophages. These findings suggest that CCL2 may be a useful target for local cell therapy in areas of bone loss.
Article
Biotechnology & Applied Microbiology
Ana M. G. Vieira, Oscar F. Silvestre, Bruno F. B. Silva, Celso J. O. Ferreira, Ivo Lopes, Andreia C. Gomes, Begona Espina, Marisa P. Sarria
Summary: This study developed nanoliposomes targeting chemokine receptor CXCR-4, which showed high cytotoxicity towards cancer cells while protecting normal cells. The acid pH-induced fusion of nanoliposomes was found to be the primary pathway for cellular internalization.
Article
Environmental Sciences
Po-Chung Ju, Yung-Chuan Ho, Pei-Ni Chen, Hsiang-Lin Lee, Szu-Yu Lai, Shun-Fa Yang, Chao-Bin Yeh
Summary: Kaempferol inhibits the invasive properties of human HCC cells by targeting MMP-9 and Akt pathways, showing potential as an adjuvant therapeutic agent for the treatment of human HCC cells.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Oncology
Solmaz Khalighfard, Vahid Khori, Ebrahim Esmati, Farahnazsadat Ahmadi, Taghi Amiriani, Amirhoushang Poorkhani, Somayeh Sadani, Saeed Khodayari, Hamid Khodayari, Mohammad Reza Kalhori, Pedram Keshavarz, Ali Mohammad Alizadeh
Summary: Filgrastim, a recombinant G-CSF, can stimulate the migration of bone marrow-derived stem/progenitor cells to the bloodstream, which helps manage chemotherapy-induced leukopenia. However, our in vitro and in vivo experiments on 4T1 cells suggest that Filgrastim may increase cell migration, invasion, and metastasis, potentially increasing the risk of cancer cell metastasis in patients continuously receiving Filgrastim treatment.
Article
Immunology
B. Aydin Ozgur, E. Coskunpinar, S. Bilgic Gazioglu, A. Yilmaz, Y. Musteri Oltulu, B. Cakmakoglu, G. Deniz, A. O. Gurol, M. T. Yilmaz
Summary: The study suggests that protein levels of CD55 and CD59, as well as polymorphisms in SDF-1 and CXCR-4, may play a predictive role in the progression, complications, and susceptibility of type 2 diabetes mellitus (T2DM). Variations in the expression of these genes and proteins were found to be associated with nephropathy, retinopathy, and cardiovascular diseases related to T2DM.
IMMUNOLOGICAL INVESTIGATIONS
(2021)
Article
Biochemistry & Molecular Biology
Tristen V. Tellman, Lissette A. Cruz, Brian J. Grindel, Mary C. Farach-Carson
Summary: The study showed that MMP-7 can digest all components of the PSPN Complex in prostate cancer cells, leading to destabilization of cell-cell junctions, promoting cell discohension and migration. This transition favors the production of circulating tumor cells and metastasis to bone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Loganayaki Periyasamy, Bharathi Murugantham, Sridhar Muthusami
Summary: A sustained increase in the mortality of pancreatic cancer (PC) and sudden metastasis-related mortality is a cause for concern. Aberrant expression of epidermal growth factor receptor (EGFR) in PC is related to its metastasis. Plumbagin has shown benefits on PC cells, but its role on cancer stem cells is unknown. This study used an EGF micro-environment to create cancer stem cells in vitro and investigated the effects of plumbagin on EGFR expression and PC progression.
Review
Medicine, Research & Experimental
Yiting Qiao, Yunxin Pei, Miao Luo, Muthukumar Rajasekaran, Kam M. Hui, Jianxiang Chen
Summary: The article summarizes the importance of cytokinesis in maintaining cell ploidy level and its critical role in human hepatocellular carcinoma, including inducing abnormal cell ploidy and being potential therapeutic targets.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Sakshi Sikka, Muthu K. Shanmugam, Kodappully Sivaraman Siveen, Tina H. Ong, Min Hee Yang, Jong Hyun Lee, Peramaiyan Rajendran, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Shireen Vali, Alan Prem Kumar, Gautam Sethi, Lingzhi Wang, Kam Man Hui, Kwang Seok Ahn
Summary: Research has shown that diosgenin can inhibit the activation of NF-Kappa B/STAT3 in prostate cancer cells and suppress tumor progression in in vivo models. This inhibition is achieved through the suppression of protein kinases and reporter gene activity, leading to reduced expression of tumorigenic gene products.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Hongjin Chen, Fubing Wu, Haojun Xu, Guanqun Wei, Min Ding, Fanggui Xu, Amudha Deivasigamani, Guoren Zhou, Kam M. Hui, Hongping Xia
Summary: Hepatocellular carcinoma (HCC) is a deadly cancer type, with overexpression of centromere proteins (CENPs) playing a critical role in its progression. Specifically, overexpression of CENPF is associated with poor survival in HCC patients, promoting cell migration and EMT progression. Silencing CENPF inhibits cell growth both in vitro and in vivo, suggesting its potential as a biomarker for tackling HCC progression.
CANCER GENE THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Kian Chuan Sia, Shu Uin Gan, Siti Humairah Mohd Rodhi, Zhen Ying Fu, John J. Kopchick, Michael J. Waters, Kok Onn Lee
Summary: This study is the first to use gene therapy to treat GH-receptor deficiency. By injecting AAV-GHR, the serum GH levels decrease and the levels of GH-responsive IGF1, IGFBP3, and ALS increase in mice. It also causes a limited increase in body weight and length, similar to the response to rhIGF1 treatment in LS patients. This study is of great importance for the development of gene therapy for human LS treatment.
Correction
Multidisciplinary Sciences
Min Thura, Abdul Qader Al-Aidaroos, Abhishek Gupta, Cheng Ean Chee, Soo Chin Lee, Kam Man Hui, Jie Li, Yeoh Khay Guan, Wei Peng Yong, Jimmy So, Wee Joo Chng, Chin Hin Ng, Jianbiao Zhou, Ling Zhi Wang, John Shyi Peng Yuen, Henry Sun Sien Ho, Sim Mei Yi, Edmund Chiong, Su Pin Choo, Joanne Ngeow, Matthew Chau Hsien Ng, Clarinda Chua, Eugene Shen Ann Yeo, Iain Bee Huat Tan, Joel Xuan En Sng, Nicholas Yan Zhi Tan, Jean Paul Thiery, Boon Cher Goh, Qi Zeng
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Loukik Arora, Chakrabhavi Dhananjaya Mohan, Min Hee Yang, Shobith Rangappa, Amudha Deivasigamani, Alan Prem Kumar, Ajaikumar B. Kunnumakkara, Manoj Garg, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Kanchugarakoppal S. Rangappa, Kam Man Hui, Gautam Sethi, Kwang Seok Ahn
Summary: STAT3 is a major oncogenic transcription factor that is constitutively activated in various human cancers, including HCC and MM. Tris DBA, a palladium-based compound, has shown inhibitory efficacy on STAT3 signaling in preclinical cancer models by elevating the expression of SHP2 and inhibiting cell proliferation, migration, invasion, and tumor metastasis. This study provides evidence for the potential consideration of Tris DBA in clinical trials for cancer treatment.
Article
Cell Biology
Ser Yue Loo, Nicholas L. Syn, Angele Pei-Fern Koh, Janet Cheng-Fei Teng, Amudha Deivasigamani, Tuan Zea Tan, Aye Aye Thike, Shireen Vali, Shweta Kapoor, Xiaoyuan Wang, Jiong Wei Wang, Puay Hoon Tan, George W. Yip, Gautam Sethi, Ruby Yun-Ju Huang, Kam Man Hui, Lingzhi Wang, Boon Cher Goh, Alan Prem Kumar
Summary: Clinical trials repurposing PPAR gamma agonists as anticancer agents have shown limited efficacy. Increased expression of PPARG is associated with better prognosis but negatively correlated with HDAC 1 and 2 expressions. Overexpression of HDAC blunts the anti-proliferative and anti-angiogenic responses to PPAR gamma agonists, which can be neutralized with HDAC inhibitors. Combined treatment with HDAC inhibitors is necessary to enhance the tumor-suppressive effects of PPAR gamma agonists in breast cancer cells, including triple-negative and endocrine-refractory subtypes. This combination therapy also inhibits angiogenesis and shows synergistic effects in ER alpha-positive cells.
CELL DEATH DISCOVERY
(2021)
Article
Biology
Chakrabhavi Dhananjaya Mohan, Min Hee Yang, Shobith Rangappa, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Amudha Deivasigamani, Kam Man Hui, Gautam Sethi, Kanchugarakoppal S. Rangappa, Kwang Seok Ahn
Summary: This study demonstrates that 3-formylchromone inhibits the activated STAT3 signaling in hepatocellular carcinoma cells and effectively reduces tumor growth and metastasis in a mouse model. The researchers also found that 3-formylchromone does not cause substantial toxicity. Therefore, it has the potential to be a powerful agent for targeting STAT3 signaling in hepatocellular carcinoma.
Article
Multidisciplinary Sciences
Cunjie Chang, Muthukumar Rajasekaran, Yiting Qiao, Heng Dong, Yu Wang, Hongping Xia, Amudha Deivasigamani, Minjie Wu, Karthik Sekar, Hengjun Gao, Mengqing Sun, Yuqin Niu, Qian Li, Lin Tao, Zhen Yan, Menglan Wang, Shasha Chen, Shujuan Zhao, Dajing Chen, Lina Li, Fan Yang, Haojin Gao, Baodong Chen, Ling Su, Liang Xu, Ye Chen, Veerabrahma Pratap Seshachalam, Gongxing Chen, Jayantha Gunaratne, Wanjin Hong, Junping Shi, Gongying Chen, David S. Grierson, Benoit Chabot, Tian Xie, Kam Man Hui, Jianxiang Chen
Summary: In this study, the authors investigate the role of the splice variant of SREK1 and its upstream regulator SRSF10 in sustaining the oncogenic signal in hepatocarcinogenesis.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Min Hee Yang, Chakrabhavi Dhananjaya Mohan, Amudha Deivasigamani, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S. Rangappa, Sang Hoon Jung, Hyejin Ko, Kam Man Hui, Gautam Sethi, Kwang Seok Ahn
Summary: Procaine inhibits the EMT process and c-Met-dependent signaling cascades, suggesting its potential as an anti-metastatic agent for HCC.
Article
Biochemistry & Molecular Biology
Jingwen Zhang, Young Yun Jung, Chakrabhavi Dhananjaya Mohan, Amudha Deivasigamani, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S. Rangappa, Kam Man Hui, Gautam Sethi, Kwang Seok Ahn
Summary: This study investigates the combinational effect of docetaxel (DTX) and nimbolide (NL) on advanced prostate cancer. The results show that the co-administration of NL and DTX significantly reduces cell viability and enhances apoptosis in prostate cancer cells. NL also abolishes DTX-induced NF-kappa B activation and expression of antiapoptotic factors. The combination of NL and DTX demonstrates a synergistic antitumor effect and reduces metastases in prostate cancer models.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Review
Oncology
Mangala Hegde, Sosmitha Girisa, Nikunj Naliyadhara, Aviral Kumar, Mohammed S. Alqahtani, Mohamed Abbas, Chakrabhavi Dhananjaya Mohan, Sudha Warrier, Kam Man Hui, Kanchugarakoppal S. Rangappa, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: This review focuses on the therapeutic effects of natural compounds targeting nuclear receptors (NRs) in cancer treatment, highlighting their advantages and limitations. The study emphasizes the importance of NRs in gene expression regulation and the potential of natural compounds as oncology drugs.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Oncology
Min Hee Yang, Mina Lee, Amudha Deivasigamani, Duc Dat Le, Chakrabhavi Dhananjaya Mohan, Kam Man Hui, Gautam Sethi, Kwang Seok Ahn
Summary: Decanoic acid (DA) has been found to suppress the activation of c-Met and induce apoptosis in hepatocellular carcinoma cells, inhibiting tumor growth and progression. It has also shown anti-tumor effects in preclinical cancer models. Thus, DA has the potential to be a new therapeutic agent for hepatocellular carcinoma.
Article
Gastroenterology & Hepatology
Miran Kim, Kam Man Hui, Ming Shi, Nancy Reau, Costica Aloman
Summary: This study investigated the differential expression of hepatic cancer stem cells and hypoxia in residual HCC after TACE treatment. The findings suggest that these markers can predict non-response to TACE and that TACE-induced hypoxia may select for an aggressive HCC phenotype.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Chengfei Zhang, Xiaoming Wang, Dan Fang, Ping Xu, Xiao Mo, Chao Hu, Alaa Abdelatty, Mei Wang, Haojun Xu, Qi Sun, Guoren Zhou, Junjun She, Jinglin Xia, Kam Man Hui, Hongping Xia
Summary: The study revealed that STK39 is highly overexpressed in clinical HCC tissues, induced by transcription factor SP1, and correlated with poor patient survival. Overexpression of STK39 promoted HCC cell proliferation, migration, and invasion, while depletion of STK39 attenuated growth and metastasis. Knockdown of STK39 induced HCC cell cycle arrest and apoptosis.