Article
Immunology
Caitlin K. Posillico, Rosa E. Garcia-Hernandez, Natalie C. Tronson
Summary: This study characterized the physiological and inflammatory response of the hippocampus in male and female mice following administration of polyinosinic:polycytidylic acid (poly I:C). Results showed that males exhibited a greater response in inflammatory markers compared to females, with specific sex differences in the antiviral response. These findings emphasize the importance of considering sex-specific roles in neuroimmune dysregulation in neurological diseases and disorders.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Alireza Soltani Khaboushan, Niloufar Yazdanpanah, Nima Rezaei
Summary: Neuroinflammation plays a fundamental role in the development of epilepsy, and proinflammatory cytokines (PICs) are crucial contributors. Understanding the role of PICs in epilepsy could provide promising targets for treatment.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei Zhang, Zhenfa Chen, Ting Wang, Xihua Wang, Ling Liu, Wenbin Huang, Shufeng Li
Summary: TMPRSS11E is upregulated in inflammatory response and its expression is increased in acute respiratory distress syndrome and LPS-stimulated epithelial cells. Knockdown of TMPRSS11E suppresses proinflammatory cytokine release and alleviates lung injury. Therefore, interventions with TMPRSS11E can aid in the treatment of pulmonary inflammation.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Immunology
Panpan Guo, Limin Yang, Mengfan Zhang, Yuyan Zhang, Yuanyuan Tong, Yanlan Cao, Jianghuai Liu
Summary: Type I IFNs play a crucial role in tumor immune surveillance and therapeutic responses, but may also have protumoral activities. Research has shown that IFN-I stimulation can lead to high expression of ARG1 in tumor-associated macrophages, and that there is a surprising IFN-to-IL-4 cytokine axis in transitional monocytes which affects macrophage phenotype conversion. This study highlights the complex interplay between IFN-I and IL-4 in regulating the tumor microenvironment and therapeutic responses.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Pietro Ghezzi, Giamila Fantuzzi, Charles A. A. Dinarello
Summary: This Perspective highlights the work of Dr. Daniela Novick on cytokine biology, specifically her identification of soluble receptors and binding proteins for various cytokines using affinity chromatography. Her findings have been crucial in the development of monoclonal antibodies against interferons and cytokines. The Perspective also discusses her recent review on this topic.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cesar G. Pelcastre-Rodriguez, Ernesto A. Vazquez-Sanchez, Jose M. Murrieta-Coxca, Sandra Rodriguez-Martinez, Juan C. Cancino-Diaz, Mario E. Cancino-Diaz
Summary: The study found that IL-36 is involved in the activation of mesangial cells and the production of inflammation, with specific members potentially playing a key role in the inflammation associated with infections in the glomerular environment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xun Gao, Paul Kay Sheung Chan, Grace Chung Yan Lui, David Shu Cheong Hui, Ida Miu-Ting Chu, Xiaoyu Sun, Miranda Sin-Man Tsang, Ben Chung Lap Chan, Christopher Wai-Kei Lam, Chun-Kwok Wong
Summary: Our study demonstrates that IL-38 plays a crucial role in inhibiting exaggerated pulmonary inflammation during viral pneumonia, offering a novel therapeutic target for respiratory viral infections. Additionally, IL-38 can alleviate inflammatory responses by targeting genes associated with the host innate immune response to virus and counteracting the effects of IL-36 alpha in lung microenvironment.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Chan Seok Lim, Yoon Ha Jang, Ga Young Lee, Gu Min Han, Hye Jin Jeong, Ji Won Kim, Jie-Oh Lee
Summary: Studies have shown that Toll-like Receptor 3 (TLR3) depends on the length of its ligands for triggering a robust immune response. In this study, the cryo-electron microscopy structure of TLR3 bound to a synthetic RNA ligand of average length 400 base pairs was determined. The structure revealed that TLR3 units form a highly organized and cooperative cluster along the double-stranded RNA helix, suggesting that ligand-induced clustering of TLR3 triggers the assembly of signaling adaptors and initiates a strong innate immune response.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Akira Nakazono, Yuji Nakamaru, Mahnaz Ramezanpour, Takeshi Kondo, Masashi Watanabe, Shigetsugu Hatakeyama, Shogo Kimura, Aya Honma, P. J. Wormald, Sarah Vreugde, Masanobu Suzuki, Akihiro Homma
Summary: SARS-CoV-2 cell entry in the nasal mucosa is promoted by the activation of innate immune signals via TLR3, but this expression is suppressed in the presence of the corticosteroid fluticasone propionate (FP). Further studies are needed to determine whether FP can suppress SARS-CoV-2 viral cell entry.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Neurosciences
Daniel Bormann, Dragan Copic, Katharina Klas, Martin Direder, Christian J. Riedl, Giulia Testa, Hannes Kuehtreiber, Emilia Poreba, Simon Hametner, Bahar Golabi, Melanie Salek, Carmen Haider, Verena Endmayr, Lisa E. Shaw, Romana Hoeftberger, Hendrik J. Ankersmit, Michael Mildner
Summary: This study investigated the acute responses of the mammalian brain to bacterial and viral PAMP challenges. It found shared and distinct responses in brain vascular and ependymal cells, limited neuronal response to PAMPs, and a pronounced dependency of oligodendrocytes on IFN stimulation during viral PAMP challenges.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Michiyo Kobayashi-Sakamoto, Toyonobu Maeda, Miyuki Kimura, Junko Yusa, Hiroshi Ito, Hideki Tani, Yasumasa Kato, Kimiharu Hirose
Summary: Bovine lactoferrin (bLF) can enhance the antiviral response in human intestinal epithelial cells and has a better inhibitory effect on SARS-CoV-2 infection.
BIOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Cell Biology
Francois Xavier Rwandamuriye, Cameron W. Evans, Ben Wylie, Marck Norret, Breana Vitali, Diwei Ho, Dat Nguyen, Ellise A. Roper, Tao Wang, Matt S. Hepburn, Rowan W. Sanderson, Maren Pfirrmann, Vanessa S. Fear, Catherine A. Forbes, Ken Wyatt, Anne L. Ryan, Terrance G. Johns, Marianne B. Phillips, Rupert Hodder, Connull Leslie, Brendan F. Kennedy, Rachael M. Zemek, Killugudi Swaminathan Iyer, Willem Joost Lesterhuis
Summary: Recurrences often occur after surgical removal of primary tumors and adjuvant therapies have limited efficacy. This study developed a surgically optimized biodegradable hydrogel for sustained release of poly(I:C) during surgery, which significantly reduced tumor recurrence in multiple mouse models. Mechanistically, poly(I:C) reshaped the tumor/wound microenvironment by inducing a temporary interferon alpha (IFNa) response, attracting inflammatory monocytes and depleting regulatory T cells. The study also demonstrated that a pre-existing IFN signature predicted the response to the poly(I:C) hydrogel, making tumors more sensitive to immune checkpoint therapy. Veterinary trial in dogs confirmed the safety, immunogenicity, and surgical feasibility of the optimized hydrogel. This surgically optimized poly(I:C)-loaded hydrogel provides a safe and effective approach to prevent cancer recurrence.
CELL REPORTS MEDICINE
(2023)
Article
Microbiology
Nele Zoellner, Noemi Coesfeld, Frederik Henry De Vos, Jennifer Denter, Haifeng C. Xu, Elena Zimmer, Birgit Knebel, Hadi Al-Hasani, Sofie Mossner, Philipp A. Lang, Doreen M. Floss, Juergen Scheller
Summary: Researchers found that synthetic type I interferon signaling mainly originates from IFNAR2, rather than IFNAR1, by reformatting the structure of IFNAR1 and IFNAR2.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Kasin Yadunandam Anandam, Cilia Abad, Tetiana Synova, Mireia Vinas-Noguera, Bahareh Bolboli, Ivan Vokral, Rona Karahoda, Frantisek Staud
Summary: Maternal inflammation during pregnancy is a major feature of several pregnancy complications and is a significant risk factor for neurodevelopmental and neuropsychiatric disorders in the offspring. The placenta, as the interface between the mother and the fetus, plays a crucial role in fetal development and immune regulation. The use of placental slices as a model helps in studying the acute inflammatory response and the role of sexual dimorphism in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Fan-Xiang Gao, Wei-Jia Lu, Yan Shi, Zhan-Wei Zhao, Li Zhou, Jian-Fang Gui, Zhe Zhao
Summary: This study systematically analyzed IFN genes in pufferfish and identified different types of IFN genes, studying their molecular characteristics and phylogenetic relationships. The results showed that these IFN genes have different expression patterns in various tissues of pufferfish and play multiple roles in antiviral responses. Additionally, specific transcription factor binding sites and induction effects were investigated.
AQUACULTURE REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Alexis Slama, Mohamed Zaatar, Muhittin Demir, Oezlem Okumus, Stefan Mattheis, Sandra Kampe, Kaid Darwiche, Stephan Lang, Clemens Aigner
Summary: The study found that in carefully selected patients, tracheal or laryngotracheal resection after previous interventions provides comparable outcomes to primary surgery.
THORACIC AND CARDIOVASCULAR SURGEON
(2022)
Article
Oncology
Sharareh Bordbari, Britta Morchen, Ekaterina Pylaeva, Elena Siakaeva, Ilona Spyra, Maksim Domnich, Freya Droege, Oliver Kanaan, Karl Sebastian Lang, Dirk Schadendorf, Stephan Lang, Iris Helfrich, Jadwiga Jablonska
Summary: This study reveals that Type I interferon-deficient tumor-associated neutrophils play a significant role in promoting angiogenesis in tumors by releasing pro-angiogenic factors and activating the transcription factor FOXO3a. The post-translational modifications of FOXO3a control its transcriptional activity, which ultimately regulates the expression of pro-angiogenic factors. Targeting FOXO3a activity could be a potential strategy for antiangiogenic targeted therapy in cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Irem Ozel, Inga Duerig, Maksim Domnich, Stephan Lang, Ekaterina Pylaeva, Jadwiga Jablonska
Summary: Tumor angiogenesis is a critical step in cancer progression, and neutrophils have been found to play an important role in this process. This review summarizes the pro-angiogenic functions of neutrophils and discusses the potential for targeting these cells in anti-cancer therapy.
Article
Multidisciplinary Sciences
Anna Wrobeln, Tristan Leu, Jadwiga Jablonska, Urban Geisthoff, Stephan Lang, Joachim Fandrey, Freya Droege
Summary: Patients with hereditary haemorrhagic telangiectasia (HHT) suffer from abnormal vessel structures, leading to vessel hemorrhage and shunt effects. This study found significantly decreased expression of HIF-1 alpha in HHT patients, with no effect on the known upstream regulators of HIF-1 alpha. The results highlight the importance of HIF in HHT and suggest an interaction between the known HHT mutation and HIF-1 alpha dysregulation in HHT patients.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Johannes Doescher, Moritz Meyer, Christoph Arolt, Alexander Quaas, Jens Peter Klussmann, Philipp Wolber, Agnes Bankfalvi, Hans-Ulrich Schildhaus, Tobias Bastian, Stephan Lang, Simon Laban, Patrick J. Schuler, Cornelia Brunner, Thomas K. Hoffmann, Stephanie E. Weissinger
Summary: Adenoid cystic carcinoma (ACC) is a rare tumor with late occurring metastases and recurrences. The lack of effective treatment in the palliative situation and unsuccessful trials on immunotherapeutic drugs show the need for prognostic markers and understanding the reasons for the lack of response to immunotherapy. The study found that ACC is not recognized by infiltrating immune cells, suggesting the need for other methods to induce recognition of ACC by the immune system. The low immunogenicity of ACC and the abundance of lymphocytes have no influence on prognosis, explaining the observed lack of response towards immunotherapy.
Article
Chemistry, Multidisciplinary
Ronja Schirrmann, Michael Erkelenz, Kim Lamers, Oliver Sritharan, Milen Nachev, Bernd Sures, Sebastian Schluecker, Sven Brandau
Summary: This study investigates the uptake, intracellular processing, and cell biological response induced by AuNRs in PMNs, demonstrating that AuNRs mainly enter cells through phagocytosis and macropinocytosis, leading to protein stress and pro-inflammatory response.
Article
Audiology & Speech-Language Pathology
Laura Christine Holtmann, Amadea Strahlenbach, Stefan Hans, Stephan Lang, Diana Arweiler-Harbeck
Summary: The medial olivocochlear reflex (MOCR) may affect bimodal hearing in some individuals, but it is not observable in all cases. Threshold changes observed in acoustic brainstem response (ABR) measurements were reproducible in a specific subgroup, potentially due to a reactivated MOCR.
AUDIOLOGY AND NEURO-OTOLOGY
(2023)
Article
Otorhinolaryngology
Benedikt Hoeing, L. Wittig, L. Weber, B. A. Stuck, S. Mattheis, T. Hussain, S. Lang, J. M. Theysohn, Y. Li, S. Hansen
Summary: This retrospective study aimed to investigate the use of abdominal ultrasound as a staging procedure in head and neck squamous cell carcinoma (HNSCC). Out of 426 patients who received abdominal ultrasound, 7% were suspected of metastasis, with the majority being liver masses. The study found that abdominal ultrasound had a negative predictive value of 99.03% and a positive predictive value of 5.88% in HNSCC patients with N2/N3 cervical lymph node status.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Eric Deuss, Saskia Schieder, Stephan Lang, Stefan Mattheis, Orlando Guntinas-Lichius, Moritz Friedo Meyer
Summary: This survey aimed to assess the diagnostic workup and therapeutic strategies for salivary gland diseases in German otorhinolaryngology departments. The results showed diversity in the diagnosis and treatment methods, with variations in different locations.
Review
Immunology
Benedict Boateng Antuamwine, Rebeka Bosnjakovic, Francisca Hofmann-Vega, Xi Wang, Theodosios Theodosiou, Ioannis Iliopoulos, Sven Brandau
Summary: Research on tumor-associated neutrophils (TAN) is currently booming due to the strong clinical relevance of these neutrophils in tumor progression. Recent high-dimensional analysis of murine neutrophils has revealed their unexpected plasticity in cancer and other inflammatory diseases. However, the functional validation of different transcriptional states and phenotypes of neutrophils in cancer is still lacking, calling for the refinement of current concepts in order to bridge the gap between experimental insight and clinical translation.
IMMUNOLOGICAL REVIEWS
(2023)
Meeting Abstract
Oncology
C. Kuerten, A. Kulkarni, L. Vujanovic, A. Cillo, S. Lang, R. Ferris
Article
Oncology
Antonio Hrvat, Mathias Schmidt, Bernd Wagner, Denise Zwanziger, Rainer Kimmig, Lothar Volbracht, Sven Brandau, Nina Mallmann-Gottschalk
Summary: This study discovered that malignant ascites has inhibitory effects on the antitumor activity of healthy donor NK and T cells. Imbalanced electrolytes in ascites were identified as crucial factors causing immunosuppression of NK and T cells. Selective inhibition of sodium electrolyte channels can restore intracellular calcium flux and signaling pathways, thereby enhancing immune cell activity. The findings were correlated with poor patient prognosis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Meeting Abstract
Immunology
M. Domnich, E. Pylaeva, E. Siakaeva, I. Spyra, I. Ozel, S. Lang, M. Pietrowska, J. Jablonska
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
E. Pylaeva, I. Spyra, I. Oezel, M. Domnich, B. Hoeing, C. Haist, H. Hanenberg, S. Lang, J. Jablonska
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Oncology
M. Pogorzelski, W. Fendler, C. Berliner, T. Hussain, S. Lang, S. Ting, K. W. Schmid, H. -U. Schildhaus, T. Gauler, M. Stuschke, K. Laue, K. Herrmann, V. Gruenwald, M. Schuler, S. Kasper-Virchow
ONCOLOGY RESEARCH AND TREATMENT
(2022)