Review
Genetics & Heredity
Shuting Chen, Qinchao Hu, Xiaoan Tao, Juan Xia, Tong Wu, Bin Cheng, Juan Wang
Summary: Retinoids, derivatives of vitamin A, have regulatory functions in cancer prevention and treatment. Studies have shown that retinoids can reduce cancer recurrence and improve clinical response in certain solid cancers.
FRONTIERS IN GENETICS
(2022)
Review
Nutrition & Dietetics
Jee Ah Kim, Ja-Hyun Jang, Soo-Youn Lee
Summary: Vitamin A and carotenoids function as powerful antioxidants in modulating oxidative stress and cancer development; despite their protective roles, limitations exist in their application for breast cancer prevention and treatment; research demonstrates evidence regarding their association with cancer risk, cancer mechanisms, and updates in clinical practice.
Review
Oncology
Nusrat Jan, Shazia Sofi, Hina Qayoom, Burhan Ul Haq, Aisha Shabir, Manzoor Ahmad Mir
Summary: Breast cancer stem cells (BCSCs) are a small sub-population of cells within a breast tumor that have self-renewal and differentiation abilities, and are responsible for tumor formation, initiation, and recurrence. BCSCs contribute to chemoresistance in breast cancer, and targeting them with novel therapeutic strategies, such as retinoids like Adapalene, shows promise for combating this disease.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ivan Pinos, Jianshi Yu, Nageswara Pilli, Maureen A. Kane, Jaume Amengual
Summary: This study investigated the effects of exogenous retinoic acid on murine bone marrow-derived macrophages (BMDMs) and the role of interleukin 4 (IL4) in vitamin A homeostasis. The results showed that exogenous retinoic acid synergized with IL4 to regulate anti-inflammatory pathways in macrophages. IL4 also stimulated retinoic acid production and secretion in a STAT6-dependent manner.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Biochemistry & Molecular Biology
Maryam Honarbakhsh, Kiana Malta, Aaron Ericsson, Chelsee Holloway, Youn-Kyung Kim, Ulrich Hammerling, Loredana Quadro
Summary: Vitamin A deficiency leads to intestinal inflammation, compromised barrier function, and dysbiosis of the gut microbiome. Supplementing with β-carotene can improve these issues, especially in cases of severe vitamin A deficiency. Additionally, β-carotene can also influence the composition of the gut microbiome.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Cardiac & Cardiovascular Systems
Yumian Wang, Li Zhang, Han Chen, Juan Yang, Yun Cui, Hong Wang
Summary: By analyzing relevant databases, immune-related biomarkers were identified in coronary artery disease (CAD) and tumors, and a crucial gene RBP1 was discovered. RBP1 showed abnormal expression in CAD and multiple cancers, and was associated with poor prognosis, immune cell infiltration, and drug sensitivity. The findings suggest that RBP1 might mediate the development of CAD and cancer through the immune system, highlighting its potential as a common therapeutic target.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Valentina Aristarco, Harriet Johansson, Sara Gandini, Debora Macis, Cristina Zanzottera, Gianluca Tolva, Irene Feroce, Chiara Accornero, Bernardo Bonanni, Aliana Guerrieri-Gonzaga, Davide Serrano
Summary: This study found that SNPs of VDR and GC genes may influence breast cancer recurrence and survival in patients, particularly with major alleles of BsmI and TaqI showing lower risk of relapse.
Article
Cell Biology
Ana Carla Castro-Guijarro, Fiorella Vanderhoeven, Joselina Magali Mondaca, Analia Lourdes Redondo, Felipe Carlos Martin Zoppino, Juan Manuel Fernandez-Munoz, Angel Matias Sanchez, Marina Ines Flamini
Summary: All-trans retinoic acid (RA), the primary metabolite of vitamin A, plays a crucial role in controlling the development and homeostasis of organisms and tissues. The combination of RA and FAK inhibitors (FAKi) can improve the inhibition of tumor progression in breast cancer (BC) by regulating FAK expression and localization.
Article
Oncology
Lu Tian, Liang Gong, Chu Hao, Yuyang Feng, Surui Yao, Bojian Fei, Xue Wang, Zhaohui Huang
Summary: In this study, we found that ELOA is upregulated in gastric cancer and is associated with malignant characteristics and poor prognosis. Functional experiments showed that ELOA promotes gastric cancer proliferation and metastasis. Mechanistic studies revealed that ELOA exerts its oncogenic properties by activating the expression of RBP1.
Review
Nutrition & Dietetics
Helen B. Everts, Eleonore-Nausica Akuailou
Summary: Animal studies in the 1920s showed that vitamin A deficiency could lead to cancer in epithelial tissues, but typically results in death in humans. Recent research indicates that a high dietary intake of vitamin A can reduce the risk of skin cancer, specifically caused by excess exposure to UVB. This highlights the potential importance of vitamin A in preventing certain types of cancer.
Article
Nutrition & Dietetics
Agnieszka Radom, Andrzej Wedrychowicz, Stanislaw Pieczarkowski, Szymon Skoczen, Przemyslaw Tomasik
Summary: Maintaining optimal vitamin D levels after breast cancer treatment is important for reducing recurrence risk and extending survival time. A study in Polish women after mastectomy found that vitamin D deficiency was more common in this group compared to the general population, highlighting the importance of vitamin D supplementation and monitoring. By providing recommendations and increasing awareness about vitamin D supplementation, there was a significant increase in the number of patients who started supplementing and the average dose of supplements.
Review
Nutrition & Dietetics
Christine A. VanBuren, Helen B. Everts
Summary: Vitamin A is essential for the growth of healthy skin and hair, but excessive or inadequate intake can have detrimental effects. Retinoic acid and retinal are the active metabolites of vitamin A, regulating the functioning of hair follicle stem cells, the hair cycle, wound healing, and melanocyte differentiation and proliferation. UV exposure lowers retinoid levels in the skin, and the source of retinal for melanogenesis initiation is currently unknown.
Article
Biochemistry & Molecular Biology
Cesar I. Fernandez-Lazaro, Miguel Angel Martinez-Gonzalez, Inmaculada Aguilera-Buenosvinos, Alfredo Gea, Miguel Ruiz-Canela, Andrea Romanos-Nanclares, Estefania Toledo
Summary: The study found no significant protective associations between dietary vitamins A, C, and E, selenium, or zinc and breast cancer risk.
Review
Nutrition & Dietetics
Giuseppina Augimeri, Francesca Ida Montalto, Cinzia Giordano, Ines Barone, Marilena Lanzino, Stefania Catalano, Sebastiano Ando, Francesca De Amicis, Daniela Bonofiglio
Summary: The traditional Mediterranean Diet, rich in bioactive compounds like polyphenols, retinoids, and PUFAs, has been shown to have beneficial effects against chronic illnesses. These compounds possess antioxidant, anti-inflammatory, and antitumoral properties, making them potential candidates for future anticancer therapeutics in breast cancer.
Article
Nutrition & Dietetics
Huiyeon Song, Ansun Jeong, Thi Xuan Mai Tran, Jiseon Lee, Mikyung Kim, Boyoung Park
Summary: This study investigated the association between micronutrient intake and breast cancer risk in South Korean women. The study found that overall, there was no significant association between micronutrients and breast cancer risk. However, in obese women, exceeding the recommended intake levels of vitamin C and vitamin B6 was associated with a lower risk of breast cancer.
Article
Chemistry, Analytical
Jace W. Jones, Keely Pierzchalski, Jianshi Yu, Maureen A. Kane
ANALYTICAL CHEMISTRY
(2015)
Article
Developmental Biology
Monica W. Best, Juanjuan Wu, Samuel A. Pauli, Maureen A. Kane, Keely Pierzchalski, Donna R. Session, Dori C. Woods, Weirong Shang, Robert N. Taylor, Neil Sidell
MOLECULAR HUMAN REPRODUCTION
(2015)
Article
Chemistry, Multidisciplinary
Xin Song, Nicola Gasparini, Masrur Morshed Nahid, Hu Chen, Sky Marie Macphee, Weimin Zhang, Victoria Norman, Chenhui Zhu, Daniel Bryant, Harald Ade, Iain McCulloch, Derya Baran
ADVANCED FUNCTIONAL MATERIALS
(2018)
Article
Reproductive Biology
Keely Pierzchalski, Robert N. Taylor, Ceana Nezhat, Jace W. Jones, Joseph L. Napoli, Guixiang Yang, Maureen A. Kane, Neil Sidell
BIOLOGY OF REPRODUCTION
(2014)
Article
Endocrinology & Metabolism
Juliana Gutierrez-Mazariegos, Eswar Kumar Nadendla, Daniela Lima, Keely Pierzchalski, Jace W. Jones, Maureen Kane, Jun-Ichi Nishikawa, Youhei Hiromori, Tsuyoshi Nakanishi, Miguel M. Santos, L. Filipe C. Castro, William Bourguet, Michael Schubert, Vincent Laudet
Article
Biochemistry & Molecular Biology
Sara E. Billings, Keely Pierzchalski, Naomi E. Butler Tjaden, Xiao-Yan Pang, Paul A. Trainor, Maureen A. Kane, Alexander R. Moise
Article
Obstetrics & Gynecology
Samuel A. Pauli, Donna R. Session, Weirong Shang, Kirk Easley, Friedrich Wieser, Robert N. Taylor, Keely Pierzchalski, Joseph L. Napoli, Maureen A. Kane, Neil Sidell
REPRODUCTIVE SCIENCES
(2013)
Article
Chemistry, Physical
Mary Allison Kelly, Qianqian Zhang, Zhengxing Peng, Victoria Noman, Chenhui Zhu, Harald Ade, Wei You
JOURNAL OF MATERIALS CHEMISTRY A
(2018)
Article
Multidisciplinary Sciences
Dan Ye, Sintu Rongpipi, Sarah N. Kiemle, William J. Barnes, Arielle M. Chaves, Chenhui Zhu, Victoria A. Norman, Alexander Liebman-Pelaez, Alexander Hexemer, Michael F. Toney, Alison W. Roberts, Charles T. Anderson, Daniel J. Cosgrove, Esther W. Gomez, Enrique D. Gomez
NATURE COMMUNICATIONS
(2020)
Article
Physics, Applied
Sridhar Majety, Pranta Saha, Victoria A. Norman, Marina Radulaski
Summary: Silicon carbide integrated photonics plays a significant role in quantum networking, simulation, and computing, with wide-ranging applications.
JOURNAL OF APPLIED PHYSICS
(2022)
News Item
Physics, Multidisciplinary
Victoria A. Norman, Marina Radulaski
Article
Materials Science, Multidisciplinary
Eli Baum, Amelia Broman, Trevor Clarke, Natanael C. Costa, Jack Mucciaccio, Alexander Yue, Yuxi Zhang, Victoria Norman, Jesse Patton, Marina Radulaski, Richard T. Scalettar
Summary: This paper investigates the high fidelity quantum state transfer in the case of comparable cavity-emitter interaction rates and cavity-cavity coupling rates. It utilizes a Monte Carlo approach to solve the inverse eigenvalue problem and determine the optimal coupling rates. The time evolution of the polariton wave function is studied through exact diagonalization of the resulting Jaynes-Cummings-Hubbard Hamiltonian. The effect of inhomogeneous emitter locations is also evaluated.
Article
Materials Science, Multidisciplinary
Victoria A. Norman, Sridhar Majety, Zhipan Wang, William H. Casey, Nicholas Curro, Marina Radulaski
Summary: Color centers are versatile systems that play a key role in advancing fundamental knowledge and expanding the boundaries of scientific disciplines, offering new opportunities for interdisciplinary fundamental discoveries in fields such as physics and geochemistry with recent advancements in material processing and device fabrication.
Article
Chemistry, Physical
Matthew T. Murachver, Ahlam Nemati, Mirostaw Salamonczyk, Carson Bullock, Zachary Sabata, Haumed Rahmani, Tetiana Vorobiova, Alain Izadnegandar, Seyyed Muhammad Salili, Victoria Norman, Chenhui Zhu, Torsten Hegmann, Samuel N. Sprunt, James T. Gleeson, Antal Jakli