Article
Biochemistry & Molecular Biology
Daniel Salas-Lloret, Roman Gonzalez-Prieto
Summary: Ubiquitination and SUMOylation are dynamic post-translational modifications that regulate cellular processes. The understanding of these modifications has been increased by the development of mass spectrometry-based approaches. This translated article provides a concise overview of the basic mechanisms of ubiquitination and SUMOylation, as well as recent MS-based approaches for specific target identification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Stefania Pieroni, Marilena Castelli, Danilo Piobbico, Simona Ferracchiato, Damiano Scopetti, Nicola Di-Iacovo, Maria Agnese Della-Fazia, Giuseppe Servillo
Summary: A cancer outcome is a multifactorial event that arises from both external injuries and internal predisposing factors. Protein synthesis, controlled by post-translational modifications, plays a crucial role in cellular function regulation. The correct activity of post-translational machinery is essential to prevent the development of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Clotilde C. N. Renaud, Nicolas Bidere
Summary: Centriolar satellites are small granules that revolve around the centrosome, and recent research has uncovered their complex nature and diverse roles in cellular processes beyond centrosome and primary cilia formation. Post-translational modifications like phosphorylation and ubiquitination play a crucial role in shaping the composition and functions of these structures.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Eugene Varfolomeev, Domagoj Vucic
Summary: Receptor interacting protein 1 (RIP1) kinase is a critical regulator of inflammation and cell death signaling, and its post-translational modifications, such as ubiquitination, phosphorylation, and cleavage, greatly impact its function in signaling pathways.
BIOCHEMICAL JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Yanxiang Meng, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy
Summary: This article discusses the role of phosphorylation, ubiquitylation, GlcNAcylation, proteolytic cleavage, and disulfide bonding in regulating necroptotic signaling, with a focus on RIPK1, RIPK3, and MLKL. Understanding of these post-translational modifications can be valuable in efforts to therapeutically modulate necroptosis.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Biochemistry & Molecular Biology
Xueyuan Leng, Julien P. Duxin
Summary: Covalent binding of proteins to DNA forms DNA-protein crosslinks (DPCs), which are cytotoxic DNA lesions that interfere with essential processes such as DNA replication and transcription. Cells have enzymatic activities to counteract DPCs, including degrading proteins, resolving crosslinks, or incising DNA to remove crosslinked proteins. Despite the inherent role of DNA replication in triggering DPC removal, efficient sensing and removal of DPCs can also occur in the absence of DNA replication. Post-translational modifications (PTMs) on DPCs play essential roles in orchestrating repair routes, with ubiquitylation, SUMOylation, and PARylation being key mechanisms. There are still knowledge gaps and emerging hypotheses in this field.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ashish Prasad, Shambhavi Sharma, Manoj Prasad
Summary: This article discusses the importance of post-translational modifications (PTMs) in plant-virus interaction. The interactions between viral proteins and components of PTM pathways play a crucial role in regulating the function of viral proteins and gene expression.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2023)
Review
Oncology
Ziad Omran, Mahmood H. Dalhat, Omeima Abdullah, Mohammed Kaleem, Salman Hosawi, Fahad A. Al-Abbasi, Wei Wu, Hani Choudhry, Mahmoud Alhosin
Summary: TAp73, a tumor suppressor in the p53 family, is regulated by multiple post-translational modifications. Understanding and targeting these modifications offer promising strategies for cancer therapy, regardless of p53 status.
Review
Biotechnology & Applied Microbiology
Haiying Wang, Liqian Yang, Minghui Liu, Jianyuan Luo
Summary: Posttranslational modifications (PTMs) of proteins play important roles in regulating cellular physiological and pathological processes. New modifications like succinylation, hydroxybutyrylation, and lactylation introduce a new layer to protein regulation with wide application prospects.
CANCER GENE THERAPY
(2023)
Review
Physiology
Kelsey S. Kalous, Sarah L. Wynia-Smith, Brian C. Smith
Summary: Increased sirtuin deacylase activity is associated with longer lifespan and lower susceptibility to aging-related diseases in eukaryotes, while decreased activity is linked to higher disease risk. Oxidative post-translational modifications such as cysteine nitrosation and glutathionylation can inhibit sirtuin deacylase activity, potentially providing a mechanistic link between cellular oxidants and age-related disease development.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Julia Kraxner, Charlotta Lorenz, Julia Menzel, Iwan Parfentev, Ivan Silbern, Manuela Denz, Henning Urlaub, Blanche Schwappach, Sarah Koester
Summary: The mechanical properties of biological cells are influenced by the cytoskeleton, with phosphorylation serving as a fast mechanism for mechanical modulation. Phosphorylation can soften filaments, and the binding of 14-3-3 protein to phosphorylated filaments further enhances this effect, potentially preserving the softening and altering cell mechanics in the cell.
Article
Cell Biology
Mohd Shariq, Neha Quadir, Javaid Ahmad Sheikh, Alok Kumar Singh, William R. Bishai, Nasreen Z. Ehtesham, Seyed E. Hasnain
Summary: The host utilizes ubiquitin pathway to combat intracellular pathogens, while pathogens like Mycobacterium tuberculosis exploit this pathway to dampen host innate immune response.
Review
Cell Biology
Li Chen, Anna Kashina
Summary: Post-translational modifications (PTM) involve enzyme-mediated covalent addition of functional groups to proteins during or after synthesis, greatly increasing biological complexity and playing a crucial role in biological regulation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Multidisciplinary Sciences
Ji Min Lee, Henrik M. Hammaren, Mikhail M. Savitski, Sung Hee Baek
Summary: Post-translational modifications (PTMs) on specific amino acids control the stability of target proteins. These PTM-regulated degrons act as signals for protein degradation or stabilization. This review summarizes the current knowledge of PTM-mediated protein stability regulation to enhance the identification of novel drug targets.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Meredith Juncker, Catherine Kim, Ryan Reed, Arthur Haas, Joshua Schwartzenburg, Shyamal Desai
Summary: The study reveals defective mitophagy in neurodegenerative diseases such as Ataxia Telangiectasia and Amyotrophic Lateral Sclerosis, which is associated with constitutively elevated ISG15 pathway. Inhibition of the ISG15 pathway restores mitophagy, reduces oxidative stress, and unhealthy mitochondria levels, suggesting a potential therapeutic avenue for neurodegenerative disorders.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)