Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A

(2011) A. Salas et al.   BLOOD

A potent sphingomyelinase inhibitor fromCordycepsmycelia contributes its cytoprotective effect against oxidative stress in macrophages

(2011) Shwu-Huey Wang et al.   JOURNAL OF LIPID RESEARCH

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

(2010) Jianming Zhang et al.   NATURE

Glycogen synthase kinase 3: more than a namesake

(2009) Geetha Vani Rayasam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glycogen Synthase Kinase-3  Facilitates IFN- -Induced STAT1 Activation by Regulating Src Homology-2 Domain-Containing Phosphatase 2

(2009) C.-C. Tsai et al.   JOURNAL OF IMMUNOLOGY

Glycogen Synthase Kinase-3  Mediates Endoplasmic Reticulum Stress-Induced Lysosomal Apoptosis in Leukemia

(2009) W.-C. Huang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Oligomerization inhibition, combined with allosteric inhibition, abrogates the transformation potential of T315I-positive BCR/ABL

(2009) A A Mian et al.   LEUKEMIA

Cathepsin B release after imatinib-mediated lysosomal membrane permeabilization triggers BCR–ABL cleavage and elimination of chronic myelogenous leukemia cells

(2009) A Puissant et al.   LEUKEMIA

Translation of the Philadelphia chromosome into therapy for CML

(2008) B. J. Druker   BLOOD

Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway

(2008) C.-L. Chen et al.   BLOOD

Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy

(2008) Jia Luo   CANCER LETTERS

The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis

(2008) Susanne Schiffmann et al.   JOURNAL OF LIPID RESEARCH

Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers

(2008) Rebecca L. Shaner et al.   JOURNAL OF LIPID RESEARCH

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential Effects of Glycolipid Biosynthesis Inhibitors on Ceramide-Induced Cell Death in Neuroblastoma Cells

(2003) Erhard Bieberich et al.   JOURNAL OF NEUROCHEMISTRY