Self-adjuvanting lipoimmunogens for therapeutic HPV vaccine development: potential clinical impact

Site-Specific Incorporation of Three Toll-Like Receptor 2 Targeting Adjuvants into Semisynthetic, Molecularly Defined Nanoparticles: Application to Group A Streptococcal Vaccines

(2014) Peter M. Moyle et al.   BIOCONJUGATE CHEMISTRY

Molecular Mechanisms of TLR2-Mediated Antigen Cross-Presentation in Dendritic Cells

(2014) K.-Y. Shen et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 9 agonist enhances anti-tumor immunity and inhibits tumor-associated immunosuppressive cells numbers in a mouse cervical cancer model following recombinant lipoprotein therapy

(2014) Li-Sheng Chang et al.   Molecular Cancer

Dendritic Cell-Targeted Vaccines

(2014) Lillian Cohn et al.   Frontiers in Immunology

Cytokine and gene transcription profiles of immune responses elicited by HIV lipopeptide vaccine in HIV-negative volunteers

(2013) Laura Richert et al.   AIDS

Inhibition of TGF-β signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages

(2013) Jiao Peng et al.   CANCER LETTERS

Human dendritic cell subsets in vaccination

(2013) Karolina Palucka et al.   CURRENT OPINION IN IMMUNOLOGY

Dendritic cells in cancer immunotherapy: vaccines and combination immunotherapies

(2013) Pawel Kalinski et al.   Expert Review of Vaccines

An efficient, chemically-defined semisynthetic lipid-adjuvanted nanoparticulate vaccine development system

(2013) Peter M. Moyle et al.   Nanomedicine-Nanotechnology Biology and Medicine

Cellular Self-Defense: How Cell-Autonomous Immunity Protects Against Pathogens

(2013) F. Randow et al.   SCIENCE

Long-term CD4+ and CD8+ T-cell responses induced in HIV-uninfected volunteers following intradermal or intramuscular administration of an HIV-lipopeptide vaccine (ANRS VAC16)

(2013) Odile Launay et al.   VACCINE

TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines

(2013) Anneliese S. Tyne et al.   VACCINE

Polyfunctional CD8+ T cells are associated with the vaccination-induced control of a novel recombinant influenza virus expressing an HCV epitope

(2012) Amabel C.L. Tan et al.   ANTIVIRAL RESEARCH

Anti-tumor immune responses of tumor-associated macrophages via toll-like receptor 4 triggered by cationic polymers

(2012) Zhen Huang et al.   BIOMATERIALS

A non-oncogenic HPV 16 E6/E7 vaccine enhances treatment of HPV expressing tumors

(2012) B G Wieking et al.   CANCER GENE THERAPY

Intratumoral Injection of CpG Oligonucleotides Induces the Differentiation and Reduces the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells

(2012) Y. Shirota et al.   JOURNAL OF IMMUNOLOGY

Structure–Activity Relationships in Human Toll-like Receptor 2-Specific Monoacyl Lipopeptides

(2012) Deepak B. Salunke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recombinant Lipidated HPV E7 Induces a Th-1-Biased Immune Response and Protective Immunity against Cervical Cancer in a Mouse Model

(2012) Chiung-Yi Huang et al.   PLoS One

Liposomal SLA co-incorporated with PO CpG ODNs or PS CpG ODNs induce the same protection against the murine model of leishmaniasis

(2012) Vahid Heravi Shargh et al.   VACCINE

Worldwide burden of cervical cancer in 2008

(2011) M. Arbyn et al.   ANNALS OF ONCOLOGY

Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment

(2011) P. Allavena et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice

(2011) Tangying Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

M2 Macrophages Induced by Prostaglandin E2 and IL-6 from Cervical Carcinoma Are Switched to Activated M1 Macrophages by CD4+ Th1 Cells

(2011) M. Heusinkveld et al.   JOURNAL OF IMMUNOLOGY

TLR1/TLR2 Agonist Induces Tumor Regression by Reciprocal Modulation of Effector and Regulatory T Cells

(2011) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Precursor Frequency and Competition Dictate the HLA-A2-Restricted CD8+ T Cell Responses to Influenza A Infection and Vaccination in HLA-A2.1 Transgenic Mice

(2011) A. C. L. Tan et al.   JOURNAL OF IMMUNOLOGY

Soluble Proteins Induce Strong CD8+ T Cell and Antibody Responses through Electrostatic Association with Simple Cationic or Anionic Lipopeptides That Target TLR2

(2011) B. Y. Chua et al.   JOURNAL OF IMMUNOLOGY

Presentation of lipopeptide by dendritic cells induces anti-tumor responses via an endocytosis-independent pathway in vivo

(2011) Ying-Chyi Song et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Structure–Activity Relationships in Toll-Like Receptor 2-Agonists Leading to Simplified Monoacyl Lipopeptides

(2011) Geetanjali Agnihotri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rapid isolation and characterization of bacterial lipopeptides using liquid chromatography and mass spectrometry analysis

(2011) Yan Kwok et al.   PROTEOMICS

Immunogenicity and safety of an HIV-1 lipopeptide vaccine in healthy adults: a phase 2 placebo-controlled ANRS trial

(2010) Dominique Salmon-Céron et al.   AIDS

Immunotherapy for Cervical Cancer

(2010) Jun-Han Su et al.   BIODRUGS

Synthesis of MUC1–lipopeptide chimeras

(2010) Brendan L. Wilkinson et al.   CHEMICAL COMMUNICATIONS

Lipoproteins of Bacterial Pathogens

(2010) A. Kovacs-Simon et al.   INFECTION AND IMMUNITY

An ISCOM vaccine combined with a TLR9 agonist breaks immune evasion mediated by regulatory T cells in an orthotopic model of pancreatic carcinoma

(2010) Collin Jacobs et al.   INTERNATIONAL JOURNAL OF CANCER

Induction of protective immunity against MHC class I-deficient, HPV16-associated tumours with peptide and dendritic cell-based vaccines

(2010) Reinis   INTERNATIONAL JOURNAL OF ONCOLOGY

Beyond Cervical Cancer: Burden of Other HPV-Related Cancers Among Men and Women

(2010) Anil K. Chaturvedi   JOURNAL OF ADOLESCENT HEALTH

Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice

(2010) Qing Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

In Situ Vaccination With a TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study

(2010) Joshua D. Brody et al.   JOURNAL OF CLINICAL ONCOLOGY

Development of a HIV-1 lipopeptide antigen pulsed therapeutic dendritic cell vaccine

(2010) Amanda Cobb et al.   JOURNAL OF IMMUNOLOGICAL METHODS

A Novel HLA (HLA-A*0201) Transgenic Rabbit Model for Preclinical Evaluation of Human CD8 + T Cell Epitope-Based Vaccines against Ocular Herpes

(2010) Aziz A. Chentoufi et al.   JOURNAL OF IMMUNOLOGY

Structure−Activity Relationships in Toll-like Receptor-2 Agonistic Diacylthioglycerol Lipopeptides

(2010) Wenyan Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A recombinant lipoprotein containing an unsaturated fatty acid activates NF-κB through the TLR2 signaling pathway and induces a differential gene profile from a synthetic lipopeptide

(2010) Chih-Hsiang Leng et al.   MOLECULAR IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

The Peptide Sequence of Diacyl Lipopeptides Determines Dendritic Cell TLR2-Mediated NK Activation

(2010) Masahiro Azuma et al.   PLoS One

TLR-based immune adjuvants

(2010) Folkert Steinhagen et al.   VACCINE

HPV16 Tumor Associated Macrophages Suppress Antitumor T Cell Responses

(2009) A. P. Lepique et al.   CLINICAL CANCER RESEARCH

Regulatory T cells: how do they suppress immune responses?

(2009) S. Sakaguchi et al.   INTERNATIONAL IMMUNOLOGY

A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge

(2009) X Zhang et al.   Mucosal Immunology

A novel technology for the production of a heterologous lipoprotein immunogen in high yield has implications for the field of vaccine design

(2009) Hsin-Wei Chen et al.   VACCINE

Immunological Responses and Long-Term Treatment Interruption after Human Immunodeficiency Virus Type 1 (HIV-1) Lipopeptide Immunization of HIV-1-Infected Patients: the LIPTHERA Study

(2008) G. Pialoux et al.   Clinical and Vaccine Immunology

CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans

(2008) W. N. Haining et al.   CLINICAL CANCER RESEARCH

Behavior of immune players in the tumor microenvironment

(2008) Mikael J Pittet   CURRENT OPINION IN ONCOLOGY

Therapeutic human papillomavirus vaccines: current clinical trials and future directions

(2008) Chien-Fu Hung et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Induction of Cytotoxic T-Lymphocytes and Antitumor Activity by a Liposomal Lipopeptide Vaccine

(2008) Weihsu Chen et al.   MOLECULAR PHARMACEUTICS

Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines

(2008) Q. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A self-adjuvanting lipopeptide-based vaccine candidate for the treatment of hepatitis C virus infection

(2008) Brendon Y. Chua et al.   VACCINE

Branched and linear lipopeptide vaccines have different effects on primary CD4+ and CD8+ T-cell activation but induce similar tumor-protective memory CD8+ T-cell responses

(2008) Adriana Baz et al.   VACCINE