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Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine design

EXPERT REVIEW OF VACCINES (2010)

期刊

EXPERT REVIEW OF VACCINES

卷 9, 期 11, 页码 1315-1324

出版社

TAYLOR & FRANCIS LTD

DOI: 10.1586/ERV.10.118

关键词

adaptive immune responses; influenza; innate immune responses; NLRP3; RIG-1; TLR-7; viral pathogenesis

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Immunology

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摘要

Influenza A virus is the etiological agent of a highly contagious acute respiratory disease that causes epidemics and considerable mortality annually. It has become increasingly evident that influenza viral infection is recognized by at least three classes of pattern-recognition receptors, including TLR-7, the retinoic acid inducible gene-I and nucleotide-binding domain and leucine-rich-repeat-containing protein 3, a member of the Nod-like receptor family. This article highlights the roles of different types of innate immune receptors in influenza virus immunity versus immunopathology.

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