Challenges and developing solutions for increasing the benefits of IL-2 treatment in tumor therapy
出版年份 2014 全文链接
标题
Challenges and developing solutions for increasing the benefits of IL-2 treatment in tumor therapy
作者
关键词
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出版物
Expert Review of Clinical Immunology
Volume 10, Issue 2, Pages 207-217
出版商
Informa UK Limited
发表日期
2014-01-13
DOI
10.1586/1744666x.2014.875856
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cutting Edge: CD4+ T Cell-Derived IL-2 Is Essential for Help-Dependent Primary CD8+ T Cell Responses
- (2014) E. B. Wilson et al. JOURNAL OF IMMUNOLOGY
- Four-year survival rates for patients with metastatic melanoma who received ipilimumab in phase II clinical trials
- (2013) J. D. Wolchok et al. ANNALS OF ONCOLOGY
- Intratumoral treatment of smaller mouse neuroblastoma tumors with a recombinant protein consisting of IL-2 linked to the Hu14.18 antibody increases intratumoral CD8+ T and NK cells and improves survival
- (2013) Richard K. Yang et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment
- (2013) Thomas F Gajewski et al. CURRENT OPINION IN IMMUNOLOGY
- Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy
- (2013) Wei Liao et al. IMMUNITY
- Human IL-2 Mutein with Higher Antitumor Efficacy Than Wild Type IL-2
- (2013) T. Carmenate et al. JOURNAL OF IMMUNOLOGY
- Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease
- (2013) K.-i. Matsuoka et al. Science Translational Medicine
- Prolonged Survival of Allogeneic Islets in Cynomolgus Monkeys After Short-Term Triple Therapy
- (2012) M. Koulmanda et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Phase II trial of hu14.18-IL2 for patients with metastatic melanoma
- (2012) Mark R. Albertini et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- CTLA-4 Blockade with Ipilimumab: Long-term Follow-up of 177 Patients with Metastatic Melanoma
- (2012) P. A. Prieto et al. CLINICAL CANCER RESEARCH
- Durable Cancer Regression Off-Treatment and Effective Reinduction Therapy with an Anti-PD-1 Antibody
- (2012) E. J. Lipson et al. CLINICAL CANCER RESEARCH
- Immunotherapy in Type 1 Diabetes: A Shorter but More Winding Road?
- (2012) E. Bonifacio DIABETES
- Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs -Cell Function
- (2012) S. A. Long et al. DIABETES
- Deciphering the molecular bases of the biological effects of antibodies against Interleukin-2: A versatile platform for fine epitope mapping
- (2012) Gertrudis Rojas et al. IMMUNOBIOLOGY
- Local expression of interleukin-2 by B16 melanoma cells results in decreased tumour growth and long-term tumour dormancy
- (2012) Scott A. Gerber et al. IMMUNOLOGY
- Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates
- (2012) Timothy Millington et al. JOURNAL OF HEART AND LUNG TRANSPLANTATION
- Transient Enhanced IL-2R Signaling Early during Priming Rapidly Amplifies Development of Functional CD8 + T Effector-Memory Cells
- (2012) Iris Castro et al. JOURNAL OF IMMUNOLOGY
- Intratumoral hu14.18-IL-2 (IC) Induces Local and Systemic Antitumor Effects That Involve Both Activated T and NK Cells As Well As Enhanced IC Retention
- (2012) R. K. Yang et al. JOURNAL OF IMMUNOLOGY
- Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’
- (2012) Aron M. Levin et al. NATURE
- Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15
- (2012) Aaron M Ring et al. NATURE IMMUNOLOGY
- Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer
- (2012) Julie R. Brahmer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
- (2012) Suzanne L. Topalian et al. NEW ENGLAND JOURNAL OF MEDICINE
- Treating Human Autoimmunity: Current Practice and Future Prospects
- (2012) M. D. Rosenblum et al. Science Translational Medicine
- Selectively Expanding Subsets of T Cells in Mice by Injection of Interleukin-2/Antibody Complexes: Implications for Transplantation Tolerance
- (2012) O. Boyman et al. TRANSPLANTATION PROCEEDINGS
- Application of IL-2 therapy to target T regulatory cell function
- (2012) Ethan M. Shevach TRENDS IN IMMUNOLOGY
- Increasing the Clinical Efficacy of NK and Antibody-Mediated Cancer Immunotherapy: Potential Predictors of Successful Clinical Outcome Based on Observations in High-Risk Neuroblastoma
- (2012) Tony A. Koehn et al. Frontiers in Pharmacology
- Ab-IL2 fusion proteins mediate NK cell immune synapse formation by polarizing CD25 to the target cell-effector cell interface
- (2011) Jennifer A. A. Gubbels et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- A Low-Toxicity IL-2-Based Immunocytokine Retains Antitumor Activity Despite Its High Degree of IL-2 Receptor Selectivity
- (2011) S. D. Gillies et al. CLINICAL CANCER RESEARCH
- Central Role for Interleukin-2 in Type 1 Diabetes
- (2011) M. A. Hulme et al. DIABETES
- Development of an attenuated interleukin-2 fusion protein that can be activated by tumour-expressed proteases
- (2011) John Puskas et al. IMMUNOLOGY
- Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells
- (2011) Jonathan Sprent et al. NATURE IMMUNOLOGY
- The Yin and Yang of Interleukin-2–Mediated Immunotherapy
- (2011) Jeffrey A. Bluestone NEW ENGLAND JOURNAL OF MEDICINE
- Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis
- (2011) David Saadoun et al. NEW ENGLAND JOURNAL OF MEDICINE
- Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease
- (2011) John Koreth et al. NEW ENGLAND JOURNAL OF MEDICINE
- gp100 Peptide Vaccine and Interleukin-2 in Patients with Advanced Melanoma
- (2011) Douglas J. Schwartzentruber et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genotypes of NK Cell KIR Receptors, Their Ligands, and Fc Receptors in the Response of Neuroblastoma Patients to Hu14.18-IL2 Immunotherapy
- (2010) D. C. Delgado et al. CANCER RESEARCH
- Th17 and Regulatory T Cells in Mediating and Restraining Inflammation
- (2010) Dan R. Littman et al. CELL
- Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo
- (2010) Vandana Kalia et al. IMMUNITY
- Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells
- (2010) Matthew E. Pipkin et al. IMMUNITY
- Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity
- (2010) Thomas R. Malek et al. IMMUNITY
- Antitumor Activity of Hu14.18-IL2 in Patients With Relapsed/Refractory Neuroblastoma: A Children's Oncology Group (COG) Phase II Study
- (2010) Suzanne Shusterman et al. JOURNAL OF CLINICAL ONCOLOGY
- IL-2 Complex Treatment Can Protect Naive Mice from Bacterial and Viral Infection
- (2010) S. E. Hamilton et al. JOURNAL OF IMMUNOLOGY
- IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor subunit CD25
- (2010) S. Letourneau et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells
- (2010) C. Krieg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pharmacologic Administration of Interleukin-2
- (2009) Antonio Romo de Vivar Chavez et al. Annals of the New York Academy of Sciences
- Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression
- (2009) Ethan M. Shevach IMMUNITY
- In Vivo Expansion of Activated Naive CD8+ T Cells and NK Cells Driven by Complexes of IL-2 and Anti-IL-2 Monoclonal Antibody As Novel Approach of Cancer Immunotherapy
- (2009) J. Tomala et al. JOURNAL OF IMMUNOLOGY
- Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma
- (2009) Antoni Ribas et al. Journal of Translational Medicine
- Regulatory T Cells and Immune Tolerance
- (2008) Shimon Sakaguchi et al. CELL
- Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction
- (2008) Qizhi Tang et al. IMMUNITY
- Mechanisms of regulatory T-cell suppression – a diverse arsenal for a moving target
- (2008) Dorothy K. Sojka et al. IMMUNOLOGY
- Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation
- (2008) G.-H. Jin et al. INTERNATIONAL IMMUNOLOGY
- Interleukin-2: Evaluation of Routes of Administration and Current Delivery Systems in Cancer Therapy
- (2008) Mohamed A. Shaker et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Adjuvants targeting innate and adaptive immunity synergize to enhance tumor immunotherapy
- (2008) G. Verdeil et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Biology of Shared Cytokine Receptors
- (2007) Xinquan Wang et al. Annual Review of Immunology
- Regulatory T Cells: Mechanisms of Differentiation and Function
- (2007) Steven Z. Josefowicz et al. Annual Review of Immunology
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