☆ 4.7 Editorial Material

Immunotherapy in Type 1 Diabetes: A Shorter but More Winding Road?

DIABETES (2012)

期刊

DIABETES

卷 61, 期 9, 页码 2214-2215

出版社

AMER DIABETES ASSOC

DOI: 10.2337/db12-0648

关键词

-

类别

Endocrinology & Metabolism

向作者/读者索取更多资源

Protocol

Reagent

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Review Immunology

The long and winding road: From mouse linkage studies to a novel human therapeutic pathway in type 1 diabetes

Manuel Rojas, Luke S. Heuer, Weici Zhang, Yi-Guang Chen, William M. Ridgway

Summary: Autoimmunity is caused by a combination of genetic susceptibility and environmental provocation, leading to a loss of immune tolerance to self-proteins and the generation of autoreactive T and B cells. The Cd137 gene plays a crucial role in the immune response and its regulation, affecting the balance between regulatory and effector signals. Understanding the genetic control of T regulatory cell development and function is important for autoimmunity research.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Review Endocrinology & Metabolism

Arresting or curing type 1 diabetes: an elusive goal, but closing the gap

Pieter-Jan Martens, Conny Gysemans, Chantal Mathieu

Summary: Type 1 diabetes, a common chronic disease in children and adolescents, remains unpreventable and incurable, despite the discovery of insulin. Most patients fail to reach target HbA1c levels, leading to disease complications. The disease's heterogeneous nature necessitates treatment customized to individual characteristics, with a focus on early detection and preservation of beta cell mass for future research.

JOURNAL OF ENDOCRINOLOGY (2021)

添加到收藏夹

Review Immunology

Evolving Antibody Therapies for the Treatment of Type 1 Diabetes

Qi Ke, Charles J. Kroger, Matthew Clark, Roland M. Tisch

Summary: Type 1 diabetes (T1D) is an autoimmune disease driven by T cells, and immunotherapies using monoclonal antibodies (mAb) can selectively reestablish beta cell-specific self-tolerance. mAb have varying efficacy in modulating autoimmunity and can alter the function of immune effector cells.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Medicine, General & Internal

Immunotherapy for type 1 diabetes

L. A. Allen, C. M. Dayan

Summary: Despite advances in technology, many individuals with type 1 diabetes still face challenges in optimizing glycaemic control. Alternative treatment approaches targeting the immune system and beta cell function have shown promising results in delaying disease onset and progression. Identifying individuals who may benefit from immunotherapy to prevent disease onset remains a point of controversy in research.

BRITISH MEDICAL BULLETIN (2021)

添加到收藏夹

Article Immunology

Overcoming Obstacles in the Development of Antigen-Specific Immunotherapies for Type 1 Diabetes

Ranjeny Thomas, Jose M. Carballido, Johnna D. Wesley, Simi T. Ahmed

Summary: Antigen-specific immunotherapy shows promise for treating type 1 diabetes, but faces obstacles in clinical translation. The key to overcoming these challenges lies in collaboration and cooperation among various stakeholders.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Dendritic Cells and Their Immunotherapeutic Potential for Treating Type 1 Diabetes

Farhan Ullah Khan, Puregmaa Khongorzul, Ahmed Aziz Raki, Ashwini Rajasekaran, Denis Gris, Abdelaziz Amrani

Summary: Type 1 diabetes is caused by the destruction of pancreatic beta cells mediated by T cells. Dendritic cells play a crucial role in the initiation and development of this disease by presenting antigens to activate and regulate the immune response. Recent advancements in understanding dendritic cell function and regulation have led to the development of potential therapeutic strategies for treating type 1 diabetes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Review Immunology

Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials

Sefina Arif, Clara Domingo-Vila, Emily Pollock, Eleni Christakou, Evangelia Williams, Timothy I. M. Tree

Summary: The increasing number of immunotherapeutic clinical trials in type 1 diabetes highlights the need for robust immune-monitoring assays to detect and characterize islet specific immune responses. Islet-specific T cells can serve as biomarkers for drug selection and patient stratification in future clinical trials. This review focuses on commonly used immune-monitoring techniques and discusses the potential of combining these with single cell transcriptional profiling to gain a deeper understanding of the underlying mechanisms.

FRONTIERS IN IMMUNOLOGY (2023)

添加到收藏夹

Review Immunology

Clinical and experimental treatment of type 1 diabetes Perspectives on immunopathology and Clinical and experimental treatment of type 1 diabetes

S. Alice Long, Jane H. Buckner

Summary: This review examines the current understanding of the etiology of Type 1 diabetes (T1D), focusing on the role of immune cells in the progression of the disease. It also highlights how this knowledge is driving the development of immunotherapies for the prevention and treatment of T1D.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2022)

添加到收藏夹

Article Medicine, General & Internal

Type 1 diabetes

Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker

Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.

LANCET (2023)

添加到收藏夹

Article Nanoscience & Nanotechnology

Tetrahedral Framework Nucleic Acids Reverse New-Onset Type 1 Diabetes

Shaojingya Gao, Mi Zhou, Yanjing Li, Dexuan Xiao, Yun Wang, Yangxue Yao, Yang Gao, Xiaoxiao Cai, Yunfeng Lin

Summary: Treatment using tetrahedral framework nucleic acids (tFNAs) was shown to reverse hyperglycemia and protect insulin-secreting beta-cells in diabetic NOD mice. The tFNA treatment induced regulatory immune cells and suppressed immune responses, demonstrating the potential of tFNAs in immunotherapy for Type 1 diabetes. The mechanism may involve the modulation of cytokines, TGF-beta levels, and the STAT signal in the pancreas.

ACS APPLIED MATERIALS & INTERFACES (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Association analysis between the TLR9 gene polymorphism rs352140 and type 1 diabetes

Yimeng Wang, Ying Xia, Yan Chen, Linling Xu, Xiaoxiao Sun, Jiaqi Li, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou

Summary: The rs352140 polymorphism of the TLR9 gene is associated with the development of type 1 diabetes (T1D) in the Han Chinese population, suggesting a genetic association.

FRONTIERS IN ENDOCRINOLOGY (2023)

添加到收藏夹

Review Immunology

The Role of Heat Shock Proteins in Type 1 Diabetes

Abu Saleh Md Moin, Manjula Nandakumar, Abdoulaye Diane, Mohammed Dehbi, Alexandra E. Butler

Summary: Type 1 diabetes is a T-cell mediated autoimmune disease characterized by the recognition of pancreatic beta-cell proteins as self-antigens, leading to their loss. Heat shock proteins play diverse roles in cellular functions, protecting cells from stress and potentially impacting the pathology of diabetes.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomised controlled trial

Robin Assfalg, Jan Knoop, Kristi L. Hoffman, Markus Pfirrmann, Jose Maria Zapardiel-Gonzalo, Anna Hofelich, Anne Eugster, Marc Weigelt, Claudia Matzke, Julia Reinhardt, Yannick Fuchs, Melanie Bunk, Andreas Weiss, Markus Hippich, Kathrin Halfter, Stefanie M. Hauck, Jorg Hasford, Joseph F. Petrosino, Peter Achenbach, Ezio Bonifacio, Anette-Gabriele Ziegler

Summary: Oral insulin immunotherapy in young children at risk of developing type 1 diabetes was found to be safe, but did not show the anticipated immune response. Preliminary evidence suggests that antibody responses to oral insulin may be more frequent in children with specific INS genotypes, and that inflammatory episodes may influence T cell responses to insulin.

DIABETOLOGIA (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Shorter respiratory event duration is related to prevalence of type 2 diabetes

Junwei Guo, Lu Dai, Jinmei Luo, Rong Huang, Yi Xiao

Summary: This study found that the average duration of respiratory events is associated with the prevalence of type 2 diabetes. Shorter average apnea duration is a potential mechanism leading to type 2 diabetes along with poor sleep quality and augmented autonomic nervous system responses.

FRONTIERS IN ENDOCRINOLOGY (2023)

添加到收藏夹

Review Health Care Sciences & Services

Personalized Immunotherapies for Type 1 Diabetes: Who, What, When, and How?

Claire Deligne, Sylvaine You, Roberto Mallone

Summary: Our understanding of the immunopathological features of type 1 diabetes has improved, and personalized treatment based on disease stage and patient characteristics could enhance therapeutic efficacy.

JOURNAL OF PERSONALIZED MEDICINE (2022)

添加到收藏夹

Article Immunology

Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Clusters Based on Integrated Genomic Surveillance, Outbreak Analysis and Contact Tracing in an Urban Setting

Andreas Walker, Torsten Houwaart, Patrick Finzer, Lutz Ehlkes, Alona Tyshaieva, Maximilian Damagnez, Daniel Strelow, Ashley Duplessis, Jessica Nicolai, Tobias Wienemann, Teresa Tamayo, Malte Kohns Vasconcelos, Lisanna Huelse, Katrin Hoffmann, Nadine Luebke, Sandra Hauka, Marcel Andree, Martin P. Daeumer, Alexander Thielen, Susanne Kolbe-Busch, Klaus Goebels, Rainer Zotz, Klaus Pfeffer, Joerg Timm, Alexander T. Dilthey

Summary: Tracing SARS-CoV-2 population transmission chains remains a major challenge, but this study presents an integrated system of genomic surveillance that is capable of detecting infection chains in a large city during ongoing community transmission. The system combines viral surveillance sequencing, genetically based identification of infection clusters, integration of public health authority contact tracing data, and a user-friendly dashboard application. This integrated system can contribute to the monitoring and potentially improve the management of SARS-CoV-2 transmission in the population.

CLINICAL INFECTIOUS DISEASES (2022)

添加到收藏夹

Article Immunology

Distinguishing activated T regulatory cell and T conventional cells by single-cell technologies

Julia Reinhardt, Virag Sharma, Antigoni Stavridou, Annett Lindner, Susanne Reinhardt, Andreas Petzold, Mathias Lesche, Fabian Rost, Ezio Bonifacio, Anne Eugster

Summary: In this study, resting and antigen-responsive T effector (Tconv) and Treg cells were distinguished using single-cell technologies. Machine learning was used to identify a minimal set of 27 genes that could accurately discriminate the four-cell populations. TRIM was identified as a novel marker to distinguish Treg cells.

IMMUNOLOGY (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Is staff consistency important to parents' satisfaction in a longitudinal study of children at risk for type 1 diabetes: the TEDDY study

Jessica Melin, Kristian F. Lynch, Markus Lundgren, Carin Andren Aronsson, Helena Elding Larsson, Suzanne Bennett Johnson

Summary: This study found that sociodemographic factors, parental characteristics, and study-related variables were all related to parent study satisfaction. The factors that can be modified are particularly important for improving parent study satisfaction.

BMC ENDOCRINE DISORDERS (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Autoantibodies against ATP4A are a feature of the abundant autoimmunity that develops in first-degree relatives of patients with type 1 diabetes

Marie-Luise Zielmann, Manja Jolink, Christiane Winkler, Anne Eugster, Denise Mueller, Marlon Scholz, Anette-G Ziegler, Ezio Bonifacio

Summary: Relatives of patients with type 1 diabetes who have risk genotypes are at very high risk for the development of autoimmunity against gastric and other organs.

PEDIATRIC DIABETES (2022)

添加到收藏夹

Article Medicine, Research & Experimental

INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes

David B. Dunger, Sylvaine F. A. Bruggraber, Adrian P. Mander, M. Loredana Marcovecchio, Timothy Tree, Piotr Jaroslaw Chmura, Mikael Knip, Anke M. Schulte, Chantal Mathieu

Summary: The INNODIA consortium has established an infrastructure to evaluate clinical data and identify biomarkers for future clinical trials in newly diagnosed type 1 diabetes. They have developed a master protocol to improve phase 2 studies, including standardized assessment, collection of mechanistic data, and evaluation of combination therapies.

TRIALS (2022)

添加到收藏夹

Letter Medicine, General & Internal

SARS-CoV-2 Infections and Presymptomatic Type 1 Diabetes Autoimmunity in Children and Adolescents From Colorado, USA, and Bavaria, Germany

Marian Rewers, Ezio Bonifacio, Dominik Ewald, Cristy Geno Rasmussen, Xiaofan Jia, Laura Pyle, Anette-Gabriele Ziegler

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

添加到收藏夹

Article Immunology

A Novel Type I Interferon Primed Dendritic Cell Subpopulation in TREX1 Mutant Chilblain Lupus Patients

Anne Eugster, Denise Mueller, Anne Gompf, Susanne Reinhardt, Annett Lindner, Michelle Ashton, Nick Zimmermann, Stefan Beissert, Ezio Bonifacio, Claudia Guenther

Summary: This study analyzed the composition of dendritic cell subsets in patients with TREX1 deficiency and identified a novel myeloid dendritic cell subpopulation that is highly enriched in these patients and associated with upregulation of interferon pathway genes.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Medicine, General & Internal

A classification and regression tree analysis identifies subgroups of childhood type 1 diabetes

Peter Achenbach, Markus Hippich, Jose Zapardiel-Gonzalo, Beate Karges, Reinhard W. Holl, Agnese Petrera, Ezio Bonifacio, Anette-G Ziegler

Summary: This study identified subgroups of young patients with diabetes using the multivariable classification and regression tree analysis method. These subgroups showed significant differences in clinical and biochemical characteristics and had potential pathogenetic and therapeutic relevance.

EBIOMEDICINE (2022)

添加到收藏夹

Article Pediatrics

Successful integration of newborn genetic testing into UK routine screening using prospective consent to determine eligibility for clinical trials

Owen Martyn Bendor-Samuel, Tabitha Wishlade, Louise Willis, Parvinder Aley, Edward Choi, Rachel Craik, Yama Mujadidi, Ginny Mounce, Fenella Roseman, Arancha De la Horra Gozalo, James Bland, Nazia Taj, Ian Smith, Anette-Gabriele Ziegler, Ezio Bonifacio, Christiane Winkler, Florian Haupt, John A. Todd, Laurent Servais, Matthew D. Snape, Manu Vatish

Summary: This study investigates the use of prospective consent in a research study on genetic risk for Type 1 Diabetes using newborn screening blood spots. The methodology serves as a model for future population-based genetic research.

ARCHIVES OF DISEASE IN CHILDHOOD (2023)

添加到收藏夹

Article Cell Biology

Next Generation Biobanking: Employing a Robotic System for Automated Mononuclear Cell Isolation

Yannick F. Fuchs, Jonathan Brunner, Marc Weigelt, Anja Schieferdecker, Robert Morgenstern, Andrea Sturm, Boris Winter, Helena Jambor, Friedrich Stolzel, Leo Ruhnke, Malte von Bonin, Elke Rucker-Braun, Falk Heidenreich, Anke Fuchs, Ezio Bonifacio, Martin Bornhauser, David M. Poitz, Heidi Altmann

BIOPRESERVATION AND BIOBANKING (2023)

添加到收藏夹

Correction Endocrinology & Metabolism

Progression likelihood score identifies substages of presymptomatic type 1 diabetes in childhood public health screening (Aug, 10.1007/s00125-022-05780-9, 2022)

Andreas Weiss, Jose Zapardiel-Gonzalo, Franziska Voss, Manja Jolink, Joanna Stock, Florian Haupt, Kerstin Kick, Tiziana Welzhofer, Anja Heublein, Christiane Winkler, Peter Achenbach, Anette-Gabriele Ziegler, Ezio Bonifacio

DIABETOLOGIA (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Progression likelihood score identifies substages of presymptomatic type 1 diabetes in childhood public health screening

Andreas Weiss, Jose Zapardiel-Gonzalo, Franziska Voss, Manja Jolink, Joanna Stock, Florian Haupt, Kerstin Kick, Tiziana Welzhofer, Anja Heublein, Christiane Winkler, Peter Achenbach, Anette-Gabriele Ziegler, Ezio Bonifacio

Summary: The aim of this study was to develop strategies to identify children from the general population with late-stage presymptomatic type 1 diabetes who may benefit from immune intervention. The study found that screening for islet autoantibodies can detect undiagnosed clinical type 1 diabetes and presymptomatic type 1 diabetes in children, and a novel likelihood ratio score can predict the risk of these children developing clinical diabetes.

DIABETOLOGIA (2022)

添加到收藏夹

Review Biophysics

Potential of TCR sequencing in graft-versus-host disease

Manisha Goel, Anne Eugster, Johannes Schetelig, Ezio Bonifacio, Martin Bornhaeuser, Cornelia S. Link-Rachner

Summary: Graft-versus-host disease (GvHD) is a common complication following allogeneic haematopoietic stem cell transplantation (allo-HSCT), in which T cells play a key role. Monitoring the changes in the T cell receptor (TCR) repertoire can provide insights into the dynamics of the T cell population and the underlying mechanisms of GvHD.

BONE MARROW TRANSPLANTATION (2023)

添加到收藏夹

Article Infectious Diseases

Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021

Torsten Houwaart, Samir Belhaj, Emran Tawalbeh, Dirk Nagels, Yara Froehlich, Patrick Finzer, Pilar Ciruela, Aurora Sabria, Merce Herrero, Cristina Andres, Andres Anton, Assia Benmoumene, Dounia Asskali, Hussein Haidar, Janina von Dahlen, Jessica Nicolai, Mygg Stiller, Jacqueline Blum, Christian Lange, Carla Adelmann, Britta Schroer, Ute Osmers, Christiane Grice, Phillipp P. Kirfel, Hassan Jomaa, Daniel Strelow, Lisanna Huelse, Moritz Pigulla, Pascal Kreuzer, Alona Tyshaieva, Jonas Weber, Tobias Wienemann, Malte Kohns Vasconcelos, Katrin Hoffmann, Nadine Luebke, Sandra Hauka, Marcel Andree, Claus Jurgen Scholz, Nathalie Jazmati, Klaus Goebels, Rainer Zotz, Klaus Pfeffer, Jorg Timm, Lutz Ehlkes, Andreas Walker, Alexander T. Dilthey

Summary: This study demonstrates the successful application of an integrated genomic surveillance system in tracing the transmission chains of SARS-CoV-2 and investigating travel-associated infection clusters. The findings show the presence of two genetically defined clusters of SARS-CoV-2 isolates in Dusseldorf, with one cluster linked to nightlife venues and a returning traveler, and the other cluster representing multiple independent introductions followed by community transmission.

EUROSURVEILLANCE (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Elevations in blood glucose before and after the appearance of islet autoantibodies in children

Katharina Warncke, Andreas Weiss, Peter Achenbach, Thekla von dem Berge, Reinhard Berner, Kristina Casteels, Lidia Groele, Konstantinos Hatzikotoulas, Angela Hommel, Olga Kordonouri, Helena Elding Larsson, Markus Lundgren, Benjamin A. Marcus, Matthew D. Snape, Agnieszka Szypowska, John A. Todd, Ezio Bonifacio, Anette-G. Ziegler

Summary: The etiology of type 1 diabetes involves autoimmune responses against pancreatic beta cells. This study found heterogeneity in blood glucose control in children with high genetic risk of type 1 diabetes and suggested that islet autoimmunity occurs concurrently or subsequent to insults on the pancreatic islets.

JOURNAL OF CLINICAL INVESTIGATION (2022)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.