Article
Biology
Claudia Gomes, Marisol Zuniga, Kelly A. Crotty, Kun Qian, Nubia Catalina Tovar, Lawrence Hsu Lin, Kimon Argyropoulos, Robert Clancy, Peter Izmirly, Jill Buyon, David C. Lee, Maria Fernanda Yasnot-Acosta, Huilin Li, Paolo Cotzia, Ana Rodriguez
Summary: High levels of autoimmune antibodies, particularly anti-DNA and anti-PS antibodies, in COVID-19 patients are strongly associated with the development of severe disease, making them potential predictive biomarkers for disease severity and specific clinical manifestations.
LIFE SCIENCE ALLIANCE
(2021)
Article
Dermatology
Giuseppina Abignano, Lorraine Green, Sookhoe Eng, Paul Emery, Francesco Del Galdo
Summary: This study aimed to determine whether dynamic-optical coherence tomography (D-OCT) can provide information on microvasculopathy in patients with systemic sclerosis compared to the current gold standard, nailfold video-capillaroscopy (NVC). In conclusion, D-OCT provided qualitative and quantitative information on nailfold microvasculopathy, showing a correlation between microvascular flow density and NVC scores. The development of D-OCT as a standardized imaging technique could provide a quantitative outcome measure in clinical trials and practice.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Marcy B. Bolster, Alexis M. Cahalane, Steven K. Grinspoon, Eli M. Miloslavsky
Summary: A case report of a 44-year-old woman with rheumatoid arthritis presenting with proximal muscle weakness and myalgia, characterized by difficulty raising her arms above her head. Diagnostic tests were conducted.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Rheumatology
Kristina Elizabeth Neergaard Clark, Shiwen Xu, Moustafa Attah, Voon H. Ong, Christopher Dominic Buckley, Christopher P. Denton
Summary: This study investigated cellular differences in diffuse cutaneous systemic sclerosis (dcSSc) patients compared with healthy controls (HCs), and found differences in cell clusters between the ARA+ and ATA+ subsets, highlighting the importance of considering antibodies and disease stage in the management and trial design of dcSSc.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Multidisciplinary Sciences
P. Jacquerie, B. Andre, D. De Seny, M. Henket, L. Giltay, M. Ernst, R. Louis, M. Malaise, C. Ribbens, J. Guiot
Summary: This study aimed to assess the test-retest reliability and reproducibility of pulmonary function testing (PFT) in SSc patients with or without interstitial lung disease (ILD). The results showed that the PFT parameters were reproducible over time and in both groups, suggesting their use in clinical practice.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Hui Zhong, Jiaxin Zhou, Shangzhu Zhang, Yan Xu, Yong Hou, Mengtao Li, Dong Xu, Mengzhao Wang, Xiaofeng Zeng
Summary: Lung cancer is a common occurrence in patients with systemic sclerosis, particularly among those with family history of malignancy or interstitial lung disease. Early detection of lung cancer is crucial for improving prognosis.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Multidisciplinary Sciences
Alfredo Guillen-Del-Castillo, Manuel Lopez Meseguer, Vicent Fonollosa-Pla, Berta Saez Gimenez, Dolores Colunga-Arguelles, Eva Revilla-Lopez, Manuel Rubio-Rivas, Maria Jose Cristo Ropero, Ana Argibay, Joan Albert Barbera Mir, Xavier Pla Salas, Amaya Martinez Menaca, Ana Belen Madronero Vuelta, Antonio Lara Padron, Luis Saez Comet, Juan Antonio Domingo Morera, Cristina Gonzalez-Echavarri, Teresa Mombiela, Norberto Ortego-Centeno, Manuela Marin Gonzalez, Carles Tolosa-Vilella, Isabel Blanco, Pilar Escribano Subias, Carmen Pilar Simeon-Aznar
Summary: This study assessed severity markers and outcomes of patients with systemic sclerosis (SSc) with or without pulmonary arterial hypertension (PAH-SSc/non-PAH-SSc), and investigated the impact of interstitial lung disease (ILD) on PAH-SSc. The results showed that PAH-SSc patients had worse clinical outcomes compared to non-PAH-SSc patients, but the presence of ILD did not affect survival in PAH-SSc patients. Up-front combination therapy reduced the risk of death in PAH-SSc patients.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Si Wu, Xiaojun Tang, Liping Wu, Liangjing Lu, Xuebing Feng
Summary: This study analyzed the clinical significance of anti-Ro52 autoantibodies targeting the TRIM21 protein in various connective tissue diseases. The research found that these antibodies may appear in the early stages of CTD with lung involvement, warranting long-term follow-up.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Mengjie Chen, Qi Zhan, Zepeng Mu, Lili Wang, Zhaohui Zheng, Jinlin Miao, Ping Zhu, Yang Li
Summary: Dmatch is a method for aligning multiple scRNA-seq experiments, leveraging an external expression atlas and kernel density matching to integrate diverse datasets and extract biological insights. The method performs well in simulations and shows great potential when applied to clinical samples, enabling cell type-specific differential gene expression comparisons and revealing shared cell populations.
Article
Rheumatology
Burcu Ayoglu, Michele Donato, Daniel E. Furst, Leslie J. Crofford, Ellen Goldmuntz, Lynette Keyes-Elstein, Judith James, Susan Macwana, Maureen D. Mayes, Peter McSweeney, Richard A. Nash, Keith M. Sullivan, Beverly Welch, Ashley Pinckney, Rong Mao, Lorinda Chung, Purvesh Khatri, Paul J. Utz
Summary: Results from the SCOT clinical trial showed that HSCT had significant benefits over CTX in patients with systemic sclerosis. The objective of this study was to test the hypothesis that transplantation stabilizes the autoantibody repertoire in patients with favorable clinical outcomes. Analysis of autoantibody profiles revealed significant differences between HSCT and CTX-treated patients, suggesting that HSCT alters the autoantibody repertoire while CTX treatment does not.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Brittany L. Adler, Francesco Boin, Paul J. Wolters, Clifton O. Bingham, Ami A. Shah, Carol Greider, Livia Casciola-Rosen, Antony Rosen
Summary: Autoantibodies targeting telomere-associated proteins are found in a subset of patients with systemic sclerosis (SSc), and are associated with short lymphocyte telomere length and lung disease. These autoantibodies are rarely present in rheumatoid arthritis, myositis, and healthy controls, suggesting a specificity for SSc and idiopathic pulmonary fibrosis (IPF).
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Grace A. Hile, Patrick Coit, Bin Xu, Amanda M. Victory, Mehrnaz Gharaee-Kermani, Shannon N. Estadt, Mitra P. Maz, Jacob W. S. Martens, Rachael Wasikowski, Craig Dobry, Lam C. Tsoi, Ramiro Iglesias-Bartolome, Celine C. Berthier, Allison C. Billi, Johann E. Gudjonsson, Amr H. Sawalha, J. Michelle Kahlenberg
Summary: Photosensitivity in systemic lupus erythematosus (SLE) is associated with enhanced UVB-induced apoptosis in SLE keratinocytes. The overactive Hippo signaling pathway in SLE keratinocytes restricts YAP transcriptional activity, leading to increased UVB apoptosis. Inhibition of LATS1/2 effectively eliminates enhanced UVB-apoptosis in SLE keratinocytes.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Sophie I. E. Liem, Sam Neppelenbroek, Cynthia M. Fehres, Brigitte A. Wevers, Rene E. M. Toes, Cornelia F. Allaart, Tom W. J. Huizinga, Hans Ulrich Scherer, Jeska K. De Vries-Bouwstra
Summary: Early diagnosis of systemic sclerosis (SSc) is important. The most frequent SSc-specific autoantibodies are anti-centromere antibodies (ACA) and anti-topoisomerase I antibodies (ATA). ATA is associated with severe disease course. More detailed characterisation of the ATA-response in SSc might improve prognostication.
Review
Medicine, General & Internal
Claudio Vitali, Antonina Minniti, Francesca Pignataro, Wanda Maglione, Nicoletta Del Papa
Summary: Despite the new biotechnological agents offering new possibilities for treating pSS, completed therapeutic trials have not yielded satisfactory results. Issues such as the extreme variability of patient phenotypes and the indolent nature of the disease leading to irreversible features in some patients have been identified as reasons for the poor outcomes. Advances in disease biomarker research are also discussed as potential solutions to improve patient selection and early diagnosis.
FRONTIERS IN MEDICINE
(2021)
Review
Engineering, Chemical
Aina Umairah Mazlan, Noor Azida Sahabudin, Muhammad Akmal Remli, Nor Syahidatul Nadiah Ismail, Mohd Saberi Mohamad, Hui Wen Nies, Nor Bakiah Abd Warif
Summary: This paper discusses the importance of using data-driven models with predictive ability in medical and healthcare, particularly focusing on the application of machine learning (ML) and deep learning (DL) in cancer classification. While various methods have been applied to cancer classification, successful techniques mainly revolve around supervised and deep learning methods.