Therapeutic implications of advances in our understanding of transitional B-cell development in humans

Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones

(2010) I. Isnardi et al.   BLOOD

Biologics in the treatment of systemic lupus erythematosus

(2010) Aisha Lateef et al.   CURRENT OPINION IN RHEUMATOLOGY

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency

(2010) Menno C. van Zelm et al.   JOURNAL OF CLINICAL INVESTIGATION

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

(2010) Danielle T. Avery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus

(2009) Daniel J. Wallace et al.   ARTHRITIS AND RHEUMATISM

Effect of long-term belimumab treatment on b cells in systemic lupus erythematosus: Extension of a phase II, double-blind, placebo-controlled, dose-ranging study

(2009) Annett M. Jacobi et al.   ARTHRITIS AND RHEUMATISM

Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells

(2009) S. Suryani et al.   BLOOD

Memory B cells: Effectors of long-lived immune responses

(2009) Stuart G. Tangye et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Primary immunodeficiencies: 2009 update

(2009) Luigi D. Notarangelo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Primary immunodeficiencies

(2009) Luigi D. Notarangelo   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus

(2009) Michael P. Cancro et al.   JOURNAL OF CLINICAL INVESTIGATION

CD20 deficiency in humans results in impaired T cell–independent antibody responses

(2009) Taco W. Kuijpers et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-7 Dependence in Human B Lymphopoiesis Increases during Progression of Ontogeny from Cord Blood to Bone Marrow

(2009) Y. K. Parrish et al.   JOURNAL OF IMMUNOLOGY

Novel Human Transitional B Cell Populations Revealed by B Cell Depletion Therapy

(2009) Arumugam Palanichamy et al.   JOURNAL OF IMMUNOLOGY

Identification and Characterization of a Human CD5+ Pre-Naive B Cell Population

(2009) J. Lee et al.   JOURNAL OF IMMUNOLOGY

B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans

(2009) K. Warnatz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells

(2009) M. Rakhmanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Short- and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis

(2009) Maria Rehnberg et al.   ARTHRITIS RESEARCH & THERAPY

B cells in autoimmunity

(2009) Thomas Dörner et al.   ARTHRITIS RESEARCH & THERAPY

Reduced memory B cells in patients with hyper IgE syndrome

(2008) C. Speckmann et al.   CLINICAL IMMUNOLOGY

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

(2008) Koichi Yanaba et al.   IMMUNITY

Regulatory B cells as inhibitors of immune responses and inflammation

(2008) Jean-David Bouaziz et al.   IMMUNOLOGICAL REVIEWS

Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors

(2008) J. Andrew Duty et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T and B lymphocyte differentiation from hematopoietic stem cell

(2008) Anne Y. Lai et al.   SEMINARS IN IMMUNOLOGY