Article
Neurosciences
Lucineia Gainski Danielski, Amanda Della Giustina, Fernanda Frederico Gava, Tatiana Barichello, Fabricia Petronilho
Summary: Sepsis is a life-threatening condition that can lead to cognitive and memory damage, which may be associated with astrocytic activation and the release of inflammatory mediators.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Critical Care Medicine
Barbora Bircak-Kuchtova, Ha-Yeun Chung, Jonathan Wickel, Johannes Ehler, Christian Geis
Summary: Sepsis is a common reason for ICU admission worldwide, and sepsis-associated encephalopathy (SAE) is a frequent occurrence in these patients, causing acute brain dysfunction. SAE can lead to increased mortality, longer hospital stays, and lasting cognitive dysfunction. Currently, there is a lack of a valid biomarker for identifying and confirming SAE, as well as assessing its severity. Neurofilament light chain (NfL), a biomarker for neuroaxonal injury, has shown potential as a prognostic biomarker for SAE and for predicting long-term cognitive impairment. This review summarizes the current knowledge on biomarkers, particularly NfL, in SAE, and discusses potential future clinical applications considering existing limitations.
Review
Medicine, General & Internal
Bethan L. Carter, Jonathan Underwood
Summary: Sepsis-associated encephalopathy (SAE) is acute cognitive dysfunction caused by systemic or peripheral infection, which can occur before the clinical signs of sepsis. Early identification, treatment, and good supportive care may improve cognitive outcomes.
Review
Critical Care Medicine
Romain Sonneville, Sarah Benghanem, Lina Jeantin, Etienne de Montmollin, Marc Doman, Augustin Gaudemer, Michael Thy, Jean-Francois Timsit
Summary: Sepsis-associated encephalopathy is a severe neurological syndrome caused by sepsis. The diagnosis of SAE involves clinical evaluation, metabolic tests, electroencephalography, and neuroimaging. Early recognition, timely treatment of infection, and control of systemic factors are crucial for management, as well as long-term surveillance.
Review
Infectious Diseases
Simone C. Tauber, Marija Djukic, Johannes Gossner, Helmut Eiffert, Wolfgang Brueck, Roland Nau
Summary: Sepsis-associated encephalopathy (SAE) and septic encephalitis (SE) present different clinical manifestations, with SAE characterized by delirium and SE additionally involving neurological symptoms. The backbone of treatment is rapid optimal antibiotic therapy, while new imaging techniques hold promise as the most promising diagnostic approaches.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Article
Mathematical & Computational Biology
Lina Zhao, Yunying Wang, Zengzheng Ge, Huadong Zhu, Yi Li
Summary: The study developed a machine learning model for predicting sepsis-associated encephalopathy (SAE) with satisfactory performance. The nomogram showed good discrimination and clinical utility in individualized prediction, aiding in early detection and management of SAE.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2021)
Article
Neurosciences
Anderson Velasque Catarina, Gisele Branchini, Lais Bettoni, Jarbas Rodrigues De Oliveira, Fernanda Bordignon Nunes
Summary: Sepsis, a major cause of morbidity and mortality in ICUs worldwide, can lead to severe brain injuries. Sepsis-associated encephalopathy is primarily caused by inflammatory and oxidative processes, with damage to the blood-brain barrier playing a significant role. Further studies and experimental advancements are crucial for understanding the complex pathophysiology of SAE and developing effective treatments and therapies.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Jianhe Yue, Ying Tan, Renzheng Huan, Jin Guo, Sha Yang, Mei Deng, Yunbiao Xiong, Guoqiang Han, Lin Liu, Jian Liu, Yuan Cheng, Yan Zha, Jiqin Zhang
Summary: Sepsis-associated encephalopathy (SAE) is a diffuse cerebral dysfunction caused by systemic infection, but its pathophysiology is still unclear. Mast cells (MCs) activation plays a crucial role in neuroinflammation models, but its role in SAE has not been comprehensively investigated.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Critical Care Medicine
Daniel C. Morris, Zheng Gang Zhang, Anja K. Jaehne, Jing Zhang, Emanuel P. Rivers
Summary: Sepsis is a complex disease caused by an uncontrolled inflammatory response to infection. It originates from a localized infection and spreads throughout the bloodstream, putting all organs at risk. Septic shock is characterized by systemic hypotension and poor response to vasopressor agents. Myocardial dysfunction leads to inadequate perfusion of major organ systems, with the brain being particularly affected, resulting in acute mental status changes and cognitive dysfunction known as sepsis-associated encephalopathy. This review discusses the inflammatory mechanisms of myocardial dysfunction, the dual roles of microglia in blood-brain barrier disruption, and the impact of septic-derived exosomes on cardiac and neurological cellular function.
Article
Immunology
Lina Zhao, Yu Song, Ying Zhang, Haiying Liu, Yuehao Shen, Yan Fan, Yun Li, Keliang Xie
Summary: This study explores the role of the HIF-1a/BNIP3L signaling pathway in Sepsis Associated Encephalopathy (SAE). The results show that HIF-1a and BNIP3L promote mitochondrial damage, neuronal apoptosis, and the expression of inflammatory factors, which may be the mechanisms of SAE in critically ill patients and the perioperative period.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Yanping Zeng, Weixing Ma, Cheng Ma, Xiaohui Ren, Yan Wang
Summary: TXNDC5 is highly expressed in patients with septic shock as well as in mice with LPS-induced sepsis and mouse macrophages stimulated with LPS. Depletion of Txndc5 reduces inflammatory cytokine production and affects the recruitment of immune cells in LPS-challenged mice, ultimately alleviating sepsis by inhibiting the NF-kappa B signaling pathway. This suggests that targeting TXNDC5 may be a potential therapeutic approach for sepsis.
LABORATORY INVESTIGATION
(2022)
Review
Geriatrics & Gerontology
Hiroshi Ito, Sanae Hosomi, Yoshihisa Koyama, Hisatake Matsumoto, Yukio Imamura, Hiroshi Ogura, Jun Oda
Summary: Septic encephalopathy is an acute cerebral dysfunction that can occur in patients with sepsis, particularly affecting the hippocampus. The underlying mechanisms and treatment strategies for septic encephalopathy remain unclear, but there is hope for the development of clinically applicable therapies.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Min Yuan, Guoqing Jing, Qian Kong, Tingqian Ming, Jing Zuo, Qian Wang, Yong Feng, Wanhong Liu, Xiaojing Wu, Zhongyuan Xia
Summary: Sepsis-associated encephalopathy (SAE) is a common type of brain dysfunction caused by systemic inflammation. In this study, TIPE2 was found to be expressed in microglia and can ameliorate brain injury caused by SAE by suppressing neuroinflammation. It plays a protective role in SAE by inhibiting the activation of the RhoA/ROCK2-NF-kappa B signaling pathways.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Critical Care Medicine
Lorenzo Ferlini, Christelle Maenhout, Ilaria Alice Crippa, Armin Alvaro Quispe-Cornejo, Jacques Creteur, Fabio Silvio Taccone, Nicolas Gaspard
Summary: This study aimed to evaluate the presence of electrographic abnormalities in septic patients and their association with functional outcome and mortality. The study found that these abnormalities were associated with sepsis-associated encephalopathy and unfavorable functional outcomes, potentially impacting the prognosis of septic patients.
Article
Genetics & Heredity
Jing-Qian Zhang, Jia-Qi Pan, Zhi-Yuan Wei, Chun-Yan Ren, Fu-Xia Ru, Shou-Yue Xia, Yu-Shan He, Kaisheng Lin, Jian-Huan Chen
Summary: Recent studies suggest that A-to-I RNA editing is associated with impaired brain function and neurological disorders. This study found altered A-to-I RNA editing in the brain tissues of septic patients, with these edits being related to genes potentially implicated in neurological diseases. Additionally, fewer gene functions and pathways were enriched by edited genes in sepsis. These findings provide important insights into the role of A-to-I RNA editing in sepsis-associated encephalopathy.
FRONTIERS IN GENETICS
(2022)
Article
Neurosciences
Luis Henrique Angenendt da Costa, Nilton Nascimento dos Santos Junior, Carlos Henrique Rocha Catalao, Tarek Sharshar, Fabrice Chretien, Maria Jose Alves da Rocha
MOLECULAR NEUROBIOLOGY
(2017)
Letter
Critical Care Medicine
Anne Riche, Nicolas Adam, Antoine Monsel, Jing Xia, Olivier Langeron, Jean-Jacques Rouby
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Article
Pathology
Arnault Tauziede-Espariat, Fabrice Chretien, Gregory Jouvion, Homa Alde-Biassette, Paul Hofman
ANNALES DE PATHOLOGIE
(2018)
Article
Surgery
Philippe Tresson, Fabrizia Ballabio, Gilles Manceau, Nicolas Adam, James Lawton, Jean-Michel Davaine, Fabien Koskas
ANNALS OF VASCULAR SURGERY
(2018)
Letter
Respiratory System
Heloise Flament, Vanessa Granger, Corinne Vezinet, Viviana Marzaioli, Caroline Kannengiesser, Luc de Chaisemartin, Margarita Hurtado-Nedelec, Elena Litvinova, Jonathan Messika, Nicolas Adam, Marie-Anne Gougerot-Pocidalo, Pham My-Chan Dang, Renato Monteiro, Jamel el Benna, Olivier Langeron, Sylvie Chollet-Martin, Antoine Monsel
EUROPEAN RESPIRATORY JOURNAL
(2018)
Article
Immunology
Joana Costa d'Avila, Luciana Domett Siqueira, Aurelien Mazeraud, Estefania Pereira Azevedo, Debora Foguel, Hugo Caire Castro-Faria-Neto, Tarek Sharshar, Fabrice Chretien, Fernando Augusto Bozza
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Clinical Neurology
Sophie Peeters, Melanie Pages, Guillaume Gauchotte, Catherine Miquel, Stephanie Cartalat-Carel, Jean-Sebastien Guillamo, Laurent Capelle, Jean-Yves Delattre, Patrick Beauchesne, Marc Debouverie, Denys Fontaine, Emmanuel Jouanneau, Jean Stecken, Philippe Menei, Olivier De Witte, Philippe Colin, Didier Frappaz, Thierry Lesimple, Luc Bauchet, Manuel Lopes, Laurence Bozec, Elisabeth Moyal, Christophe Deroulers, Pascale Varlet, Marc Zanello, Fabrice Chretien, Catherine Oppenheim, Hugues Duffau, Luc Taillandier, Johan Pallud
JOURNAL OF NEUROSURGERY
(2018)
Article
Clinical Neurology
Lionel Velly, Vincent Perlbarg, Thomas Boulier, Nicolas Adam, Sebastien Delphine, Charles-Edouard Luyt, Valentine Battisti, Gregory Torkomian, Charlotte Arbelot, Russell Chabanne, Betty Jean, Carol Di Perri, Steven Laureys, Giuseppe Citerio, Alessia Vargiolu, Benjamin Rohaut, Nicolas Bruder, Nadine Girard, Stein Silva, Vincent Cottenceau, Thomas Tourdias, Olivier Coulon, Bruno Riou, Lionel Naccache, Rajiv Gupta, Habib Benali, Damien Galanaud, Louis Puybasset
Article
Oncology
Aurelie Bruno, Karim Labreche, Mailys Daniau, Blandine Boisselier, Guillaume Gauchotte, Louis Royer-Perron, Amithys Rahimian, Frederic Lemoine, Pierre de la Grange, Justine Guegan, Franck Bielle, Marc Polivka, Clovis Adam, David Meyronet, Dominique Figarella-Branger, Chiara Villa, Fabrice Chretien, Sandrine Eimer, Frederic Davi, Audrey Rousseau, Caroline Houillier, Carole Soussain, Karima Mokhtari, Khe Hoang-Xuan, Agusti Alentorn
Article
Clinical Neurology
Melanie Pages, Kevin Beccaria, Nathalie Boddaert, Raphael Saffroy, Aurore Besnard, David Castel, Frederic Fina, Doriane Barets, Emilie Barret, Ludovic Lacroix, Franck Bielle, Felipe Andreiuolo, Arnault Tauziede-Espariat, Dominique Figarella-Branger, Stephanie Puget, Jacques Grill, Fabrice Chretien, Pascale Varlet
Review
Biochemistry & Molecular Biology
Laurent Chatre, Franck Verdonk, Pierre Rocheteau, Clement Crochemore, Fabrice Chretien, Miria Ricchetti
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2017)
Article
Critical Care Medicine
Johannes Ehler, Lucinda K. Barrett, Valerie Taylor, Michael Groves, Francesco Scaravilli, Matthias Wittstock, Stephan Kolbaske, Annette Grossmann, Joerg Henschel, Martin Gloger, Tarek Sharshar, Fabrice Chretien, Francoise Gray, Gabriele Noeldge-Schomburg, Mervyn Singer, Martin Sauer, Axel Petzold
Meeting Abstract
Neurosciences
A. -C. Boulay, B. Saubamea, M. Cohen-Salmon
Review
Critical Care Medicine
Nicholas Heming, Aurelien Mazeraud, Franck Verdonk, Fernando A. Bozza, Fabrice Chretien, Tarek Sharshar
Article
Immunology
Patricia A. Reis, Pedro C. B. Alexandre, Joana C. D'Avila, Luciana D. Siqueira, Barbara Antunes, Vanessa Estato, Eduardo V. Tibirica, Franck Verdonk, Tarek Sharshar, Fabrice Chretien, Hugo C. Castro-Faria-Neto, Fernando A. Bozza
BRAIN BEHAVIOR AND IMMUNITY
(2017)