Targeting microglia for the treatment of Alzheimer’s disease

Simple In Vitro Assays to Identify Amyloid-β Aggregation Blockers for Alzheimer's Disease Therapy

(2017) Jian-Ping Guo et al.   JOURNAL OF ALZHEIMERS DISEASE

Accelerated microglial pathology is associated with Aβ plaques in mouse models of Alzheimer's disease

(2014) Rona Baron et al.   AGING CELL

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

The suppressive effects of gx-50 on Aβ-induced chemotactic migration of microglia

(2014) Yubing Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Suppression of Alzheimer-Associated Inflammation by Microglial Prostaglandin-E2 EP4 Receptor Signaling

(2014) N. S. Woodling et al.   JOURNAL OF NEUROSCIENCE

Neuronal driven pre-plaque inflammation in a transgenic rat model of Alzheimer's disease

(2014) Cecilia E. Hanzel et al.   NEUROBIOLOGY OF AGING

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microglia actions in Alzheimer’s disease

(2013) Stefan Prokop et al.   ACTA NEUROPATHOLOGICA

Aspirin-Triggered Lipoxin A4 Stimulates Alternative Activation of Microglia and Reduces Alzheimer Disease–Like Pathology in Mice

(2013) Rodrigo Medeiros et al.   AMERICAN JOURNAL OF PATHOLOGY

Entada africana fraction CH2Cl2/MEOH 5% inhibits inducible nitric oxide synthase and pro-inflammatory cytokines gene expression induced by lipopolysaccharide in microglia

(2013) Brice Ayissi Owona et al.   BMC Complementary and Alternative Medicine

Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice

(2013) Sandra Sivilia et al.   BMC NEUROSCIENCE

Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis

(2013) Isabel Lastres-Becker et al.   BRAIN

A Friend in Need May Not be a Friend Indeed: Role of Microglia in Neurodegenerative Diseases

(2013) Deepak Kaushik et al.   CNS & Neurological Disorders-Drug Targets

Neuroprotective effects of salvianolic acid B on an Aβ25–35 peptide-induced mouse model of Alzheimer's disease

(2013) Young Woo Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antibodies bound to Aβ oligomers potentiate the neurotoxicity of Aβ by activating microglia

(2013) Ramune Morkuniene et al.   JOURNAL OF NEUROCHEMISTRY

A Derivative of the Brain Metabolite Lanthionine Ketimine Improves Cognition and Diminishes Pathology in the 3×Tg-AD Mouse Model of Alzheimer Disease

(2013) Kenneth Hensley et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Xanthoceraside Inhibits Pro-inflammatory Cytokine Expression in Aβ25–35/IFN-γ–Stimulated Microglia Through the TLR2 Receptor, MyD88, Nuclear Factor-κB, and Mitogen-Activated Protein Kinase Signaling Pathways

(2013) Yue Qi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Activated Cyclin-Dependent Kinase 5 Promotes Microglial Phagocytosis of Fibrillar β-Amyloid by Up-regulating Lipoprotein Lipase Expression

(2013) Yuanhui Ma et al.   MOLECULAR & CELLULAR PROTEOMICS

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease

(2013) A. Prestia et al.   NEUROLOGY

Oleuropein aglycone counteracts Aβ42 toxicity in the rat brain

(2013) Ilaria Luccarini et al.   NEUROSCIENCE LETTERS

Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivo

(2013) Hyo Geun Kim et al.   NEUROTOXICOLOGY

Long-Term Treatment of Thalidomide Ameliorates Amyloid-Like Pathology through Inhibition of β-Secretase in a Mouse Model of Alzheimer’s Disease

(2013) Ping He et al.   PLoS One

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

(2013) Grietje Krabbe et al.   PLoS One

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

(2013) Amanda L. Wright et al.   PLoS One

Regulation of prostaglandin F2α against β amyloid clearance and its inflammation induction through LXR/RXR heterodimer antagonism in microglia

(2013) Jingjing Zhuang et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Cerebrospinal Fluid Levels ofβ-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia

(2012) Peder Buchhave   ARCHIVES OF GENERAL PSYCHIATRY

The spectrum of disease in chronic traumatic encephalopathy

(2012) Ann C. McKee et al.   BRAIN

Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in Alzheimer’s disease models

(2012) Andressa Bernardi et al.   International Journal of Nanomedicine

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Active Aβ vaccination fails to enhance amyloid clearance in a mouse model of Alzheimer's disease with Aβ42-driven pathology

(2012) Anna Nemirovsky et al.   JOURNAL OF NEUROIMMUNOLOGY

Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease

(2012) S Prasad Gabbita et al.   Journal of Neuroinflammation

Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice

(2012) Ana María Martín-Moreno et al.   Journal of Neuroinflammation

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

Transforming growth factor-β stimulates β amyloid uptake by microglia through Smad3-dependent mechanisms

(2012) Juan E. Tichauer et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways

(2012) Liyun Jia et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Sting of Alzheimer's failures offset by upcoming prevention trials

(2012) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex

(2012) Moonhee Lee et al.   NEUROBIOLOGY OF AGING

Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages

(2012) Moonhee Lee et al.   NEUROBIOLOGY OF AGING

A multifunctional peptide rescues memory deficits in Alzheimer's disease transgenic mice by inhibiting Aβ42-induced cytotoxicity and increasing microglial phagocytosis

(2012) Di Xue et al.   NEUROBIOLOGY OF DISEASE

Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in a mouse model of Alzheimer’s disease

(2012) Tomoko Kurata et al.   NEUROLOGICAL RESEARCH

CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings

(2012) T. T. Seppala et al.   NEUROLOGY

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extended results of the Alzheimer’s disease anti-inflammatory prevention trial

(2011) John C. Breitner et al.   Alzheimers & Dementia

Mechanism of Amyloid Removal in Patients With Alzheimer Disease Treated With Gantenerumab

(2011) Susanne Ostrowitzki   ARCHIVES OF NEUROLOGY

Structural Basis of C-terminal β-Amyloid Peptide Binding by the Antibody Ponezumab for the Treatment of Alzheimer's Disease

(2011) Sherry L. La Porte et al.   JOURNAL OF MOLECULAR BIOLOGY

Effects of Obovatol on GSH Depleted Glia-Mediated Neurotoxicity and Oxidative Damage

(2011) Moonhee Lee et al.   Journal of Neuroimmune Pharmacology

CD45 Deficiency Drives Amyloid-  Peptide Oligomers and Neuronal Loss in Alzheimer's Disease Mice

(2011) Y. Zhu et al.   JOURNAL OF NEUROSCIENCE

Chronic Apocynin Treatment Attenuates Beta Amyloid Plaque Size and Microglial Number in hAPP(751)SL Mice

(2011) Melinda E. Lull et al.   PLoS One

Saliva levels of Abeta1-42 as potential biomarker of Alzheimer's disease: a pilot study

(2010) Felix Bermejo-Pareja et al.   BMC Neurology

Astrocytes are GABAergic cells that modulate microglial activity

(2010) Moonhee Lee et al.   GLIA

Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury

(2009) Ann C. McKee et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

(2009) Stefan A Grathwohl et al.   NATURE NEUROSCIENCE

Toll-Like Receptor 2 Acts as a Natural Innate Immune Receptor to Clear Amyloid  1-42 and Delay the Cognitive Decline in a Mouse Model of Alzheimer's Disease

(2008) K. L. Richard et al.   JOURNAL OF NEUROSCIENCE