Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice

Molecular Mechanisms and Therapeutic Application of NSAIDs and Derived Compounds in Alzheimers Disease

(2012) M. T. Heneka et al.   Current Alzheimer Research

Does a Pro-Inflammatory Process Precede Alzheimers Disease and Mild Cognitive Impairment?

(2012) M. T. Ferretti et al.   Current Alzheimer Research

Solanezumab for the treatment of mild-to-moderate Alzheimer’s disease

(2012) Bruno P Imbimbo et al.   Expert Review of Clinical Immunology

Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier

(2012) Michelle A Erickson et al.   Journal of Neuroinflammation

Multi-Target Drugs: The Trend of Drug Research and Development

(2012) Jin-Jian Lu et al.   PLoS One

What the halted phase III γ-secretase inhibitor trial may (or may not) be telling us

(2011) Nina F. Schor   ANNALS OF NEUROLOGY

Multi-Target-Directed Ligands in Alzheimer's Disease Treatment

(2011) M. Bajda et al.   CURRENT MEDICINAL CHEMISTRY

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

(2011) Tomohiro Umeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is ‘too big to fail’

(2011) Rudy J Castellani et al.   JOURNAL OF PATHOLOGY

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease

(2011) Maria Teresa Ferretti et al.   NEUROBIOLOGY OF AGING

Mapping the Road Forward in Alzheimer's Disease

(2011) D. M. Holtzman et al.   Science Translational Medicine

Role of APP for dendritic spine formation and stability

(2011) Christian K. E. Jung et al.   EXPERIMENTAL BRAIN RESEARCH

Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Aβ42 and Alzheimer’s disease neuropathology

(2010) Masakazu Hashimoto et al.   ACTA NEUROPATHOLOGICA

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

The γ-Secretase Modulator CHF5074 Reduces the Accumulation of Native Hyperphosphorylated Tau in a Transgenic Mouse Model of Alzheimer’s Disease

(2010) Annamaria Lanzillotta et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Reimagining Alzheimer's Disease--An Age-Based Hypothesis

(2010) K. Herrup   JOURNAL OF NEUROSCIENCE

Oral Treatment with a  -Secretase Inhibitor Improves Long-Term Potentiation in a Mouse Model of Alzheimer's Disease

(2010) M. Townsend et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer's Disease Mice

(2010) Tobias Bittner et al.   PLoS One

Mechanism of amyloid plaque formation suggests an intracellular basis of A  pathogenicity

(2010) R. P. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic degeneration in Alzheimer’s disease

(2009) Thomas Arendt   ACTA NEUROPATHOLOGICA

CHF5074, a novel γ-secretase modulator, attenuates brain β-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease

(2009) BP Imbimbo et al.   BRITISH JOURNAL OF PHARMACOLOGY

 -Secretase Inhibition Reduces Spine Density In Vivo via an Amyloid Precursor Protein-Dependent Pathway

(2009) T. Bittner et al.   JOURNAL OF NEUROSCIENCE

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

(2009) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

(2008) Vivian Y. H. Hook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging

(2008) Henrieta Scholtzova et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Region-specific changes in the microanatomy of single dendritic spines over time might account for selective memory alterations in ageing hAPPsweTg2576 mice, a mouse model for Alzheimer disease

(2008) S. Middei et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

(2008) Hyoung-gon Lee et al.   NEUROCHEMISTRY INTERNATIONAL