Transglutaminase as a therapeutic target for celiac disease

Celiac Disease: Ten Things That Every Gastroenterologist Should Know

(2015) Amy S. Oxentenko et al.   Clinical Gastroenterology and Hepatology

Novel Role of the Serine Protease Inhibitor Elafin in Gluten-Related Disorders

(2014) Heather J Galipeau et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Positional cloning and next-generation sequencing identified a TGM6 mutation in a large Chinese pedigree with acute myeloid leukaemia

(2014) Li-li Pan et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Transglutaminase 6 interacts with polyQ proteins and promotes the formation of polyQ aggregates

(2013) Wen-Juan Guan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TGM2 and implications for human disease: role of alternative splicing 

(2013) Charles Greenberg   Frontiers in Bioscience-Landmark

Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants

(2013) Jihane Romanos et al.   GUT

Selective Inhibition of Extracellular Thioredoxin by Asymmetric Disulfides

(2013) Thomas R. DiRaimondo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prostate transglutaminase (TGase-4, TGaseP) enhances the adhesion of prostate cancer cells to extracellular matrix, the potential role of TGase-core domain

(2013) Wen G Jiang et al.   Journal of Translational Medicine

The Role of TG2 in Regulating S100A4-Mediated Mammary Tumour Cell Migration

(2013) Zhuo Wang et al.   PLoS One

Glucose Homeostasis in Mice Is Transglutaminase 2 Independent

(2013) Siiri E. Iismaa et al.   PLoS One

A novel extracellular role for tissue transglutaminase in matrix-bound VEGF-mediated angiogenesis

(2013) Z Wang et al.   Cell Death & Disease

SLPI and trappin-2 as therapeutic agents to target airway serine proteases in inflammatory lung diseases: current and future directions

(2012) Marie-Louise Zani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Interactions Among Secretory Immunoglobulin A, CD71, and Transglutaminase-2 Affect Permeability of Intestinal Epithelial Cells to Gliadin Peptides

(2012) Corinne Lebreton et al.   GASTROENTEROLOGY

Are Transglutaminase 2 Inhibitors Able to Reduce Gliadin-Induced Toxicity Related to Celiac Disease? A Proof-of-Concept Study

(2012) Tiina Rauhavirta et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Activation and Inhibition of Transglutaminase 2 in Mice

(2012) Laila Dafik et al.   PLoS One

Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis

(2012) J.-P. Motta et al.   Science Translational Medicine

Paracellular versus Transcellular Intestinal Permeability to Gliadin Peptides in Active Celiac Disease

(2011) Sandrine Ménard et al.   AMERICAN JOURNAL OF PATHOLOGY

Recent advances in the development of tissue transglutaminase (TG2) inhibitors

(2011) E. Badarau et al.   AMINO ACIDS

Transglutaminase 6: a protein associated with central nervous system development and motor function

(2011) Helen Thomas et al.   AMINO ACIDS

Tissue transglutaminase, inflammation, and cancer: how intimate is the relationship?

(2011) Santosh Kumar et al.   AMINO ACIDS

Role of the endogenous elastase inhibitor, elafin, in cardiovascular injury

(2011) Shirjel R. Alam et al.   BIOCHEMICAL PHARMACOLOGY

Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A

(2011) T. Rauhavirta et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Extracellular TG2: emerging functions and regulation

(2011) Alexey M. Belkin   FEBS Journal

Modifying the Protease, Antiprotease Pattern by Elafin Overexpression Protects Mice From Colitis

(2011) Jean–Paul Motta et al.   GASTROENTEROLOGY

A phase I trial of PX-12, a small-molecule inhibitor of thioredoxin-1, administered as a 72-hour infusion every 21 days in patients with advanced cancers refractory to standard therapy

(2011) Ramesh K. Ramanathan et al.   INVESTIGATIONAL NEW DRUGS

Activation of Extracellular Transglutaminase 2 by Thioredoxin

(2011) Xi Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's disease

(2011) Robin Verhaar et al.   NEUROCHEMISTRY INTERNATIONAL

Unconventional Secretion of Tissue Transglutaminase Involves Phospholipid-Dependent Delivery into Recycling Endosomes

(2011) Evgeny A. Zemskov et al.   PLoS One

Secretory Leukocyte Protease Inhibitor (SLPI) Is, like Its Homologue Trappin-2 (Pre-Elafin), a Transglutaminase Substrate

(2011) Kévin Baranger et al.   PLoS One

The prevalence of celiac disease in Europe: Results of a centralized, international mass screening project

(2010) Kirsi Mustalahti et al.   ANNALS OF MEDICINE

Acylideneoxoindoles: A new class of reversible inhibitors of human transglutaminase 2

(2010) Cornelius Klöck et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing

(2010) Jun Ling Wang et al.   BRAIN

A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination

(2010) Ramesh K. Ramanathan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Coeliac disease – a diagnostic and therapeutic challenge

(2010) Katri Kaukinen et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Redox Regulation of Transglutaminase 2 Activity

(2010) Jorunn Stamnaes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photolabeling of Tissue Transglutaminase Reveals the Binding Mode of Potent Cinnamoyl Inhibitors†

(2009) Christophe Pardin et al.   BIOCHEMISTRY

Protein 4.2 : A complex linker

(2009) Timothy J. Satchwell et al.   BLOOD CELLS MOLECULES AND DISEASES

The adenine nucleotide translocator 1 acts as a type 2 transglutaminase substrate: implications for mitochondrial-dependent apoptosis

(2009) W Malorni et al.   CELL DEATH AND DIFFERENTIATION

Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver

(2009) L. Elli et al.   DIGESTIVE AND LIVER DISEASE

Celiac Disease Revealed in 3% of Swedish 12-year-olds Born During an Epidemic

(2009) Anna Myléus et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Incidence and prevalence of diagnosed coeliac disease in Finland: Results of effective case finding in adults

(2009) Lauri J. Virta et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase

(2008) Marios Hadjivassiliou et al.   ANNALS OF NEUROLOGY

Synthesis of potent water-soluble tissue transglutaminase inhibitors

(2008) Martin Griffin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Xeno-Cannibalism as an Exacerbation of Self-Cannibalism: A Possible Fruitful Survival Strategy for Cancer Cells

(2008) W. Malorni et al.   CURRENT PHARMACEUTICAL DESIGN

Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3

(2008) Karen M. Lammers et al.   GASTROENTEROLOGY

Fibronectin-Tissue Transglutaminase Matrix Rescues RGD-impaired Cell Adhesion through Syndecan-4 and β1Integrin Co-signaling

(2008) Dilek Telci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mucosal tissue transglutaminase expression in celiac disease

(2008) Vincenzo Villanacci et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cinnamoyl Inhibitors of Tissue Transglutaminase†

(2008) Christophe Pardin et al.   JOURNAL OF ORGANIC CHEMISTRY

Extracellular Transglutaminase 2 Is Catalytically Inactive, but Is Transiently Activated upon Tissue Injury

(2008) Matthew Siegel et al.   PLoS One