标题
Molecular targeting of the GK-GKRP pathway in diabetes
作者
关键词
-
出版物
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 19, Issue 1, Pages 129-139
出版商
Informa Healthcare
发表日期
2014-10-17
DOI
10.1517/14728222.2014.965681
参考文献
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- (2014) Theodoros P. Angelopoulos et al. ADVANCES IN THERAPY
- Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinetic Profiles
- (2014) David J. St. Jean et al. JOURNAL OF MEDICINAL CHEMISTRY
- Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 3. Structure–Activity Relationships within the Aryl Carbinol Region of the N-Arylsulfonamido-N′-arylpiperazine Series
- (2014) Nobuko Nishimura et al. JOURNAL OF MEDICINAL CHEMISTRY
- Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept
- (2014) Kate S. Ashton et al. JOURNAL OF MEDICINAL CHEMISTRY
- Recent Updates on Glucokinase Activators for the Treatment of Type 2 Diabetes Mellitus
- (2014) Ajmer Grewal et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Genome-Wide Association Study Identifies Novel Loci Associated With Concentrations of Four Plasma Phospholipid Fatty Acids in the De Novo Lipogenesis Pathway
- (2013) Jason H.Y. Wu et al. Circulation-Cardiovascular Genetics
- Dose-ranging study with the glucokinase activator AZD1656 in patients with type 2 diabetes mellitus on metformin
- (2013) J. P. H. Wilding et al. DIABETES OBESITY & METABOLISM
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- (2013) Daphna Weissglas-Volkov et al. JOURNAL OF MEDICAL GENETICS
- Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors
- (2013) David J. Lloyd et al. NATURE
- Gene-centric association signals for haemostasis and thrombosis traits identified with the HumanCVD BeadChip
- (2013) Sonia Shah et al. THROMBOSIS AND HAEMOSTASIS
- Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations
- (2013) Conall M. O'Seaghdha et al. PLoS Genetics
- Discovery and Fine Mapping of Serum Protein Loci through Transethnic Meta-analysis
- (2012) Nora Franceschini et al. AMERICAN JOURNAL OF HUMAN GENETICS
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- (2012) Guanjie Chen et al. HUMAN MOLECULAR GENETICS
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- (2012) Ramakanth Sarabu et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2012) Wael Osman et al. PLoS One
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- (2012) Andrea D. Coviello et al. PLoS Genetics
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- (2011) Abbas Dehghan et al. CIRCULATION
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- (2011) G. E. Meininger et al. DIABETES CARE
- Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk
- (2011) M. G. Rees et al. DIABETOLOGIA
- Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
- (2011) Nicola Santoro et al. HEPATOLOGY
- A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium
- (2011) Kira C. Taylor et al. HUMAN MOLECULAR GENETICS
- Meta-analysis of published studies identified eight additional common susceptibility loci for Crohnʼs disease and ulcerative colitis
- (2011) Junji Umeno et al. INFLAMMATORY BOWEL DISEASES
- Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes
- (2011) Matthew G. Rees et al. JOURNAL OF CLINICAL INVESTIGATION
- Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus
- (2011) Jeffrey A. Pfefferkorn et al. JOURNAL OF MEDICINAL CHEMISTRY
- Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
- (2011) John C Chambers et al. NATURE GENETICS
- Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function
- (2011) Ching-Ti Liu et al. PLoS Genetics
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- (2011) Rozenn N. Lemaitre et al. PLoS Genetics
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- (2011) Elizabeth K. Speliotes et al. PLoS Genetics
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- (2010) W. Tang et al. BLOOD
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- (2010) Qiong Yang et al. Circulation-Cardiovascular Genetics
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- (2010) Danish Saleheen et al. Circulation-Cardiovascular Genetics
- Glucokinase-activating GCKR Polymorphisms Increase Plasma Levels of Triglycerides and Free Fatty Acids, but do not Elevate Cardiovascular Risk in the Ludwigshafen Risk and Cardiovascular Health Study
- (2010) D. H. Kozian et al. HORMONE AND METABOLIC RESEARCH
- Piragliatin (RO4389620), a Novel Glucokinase Activator, Lowers Plasma Glucose Both in the Postabsorptive State and after a Glucose Challenge in Patients with Type 2 Diabetes Mellitus: A Mechanistic Study
- (2010) Riccardo C. Bonadonna et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
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- (2010) Anna Köttgen et al. NATURE GENETICS
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- (2010) Christopher T Johansen et al. NATURE GENETICS
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- (2010) Richa Saxena et al. NATURE GENETICS
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- (2010) Josée Dupuis et al. NATURE GENETICS
- Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip
- (2009) Philippa J. Talmud et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians
- (2009) J. C. Chambers et al. DIABETES
- The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
- (2009) Nicola L. Beer et al. HUMAN MOLECULAR GENETICS
- Investigation of Functionally Liver Selective Glucokinase Activators for the Treatment of Type 2 Diabetes
- (2009) Gregory R. Bebernitz et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2009) Melanie Kolz et al. PLoS Genetics
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- (2009) Daniel I. Chasman et al. PLoS Genetics
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- (2008) Paul M. Ridker et al. AMERICAN JOURNAL OF HUMAN GENETICS
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- (2008) T. P. Torres et al. DIABETES
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- (2008) C. Lu et al. DIABETES OBESITY & METABOLISM
- Biophysical Characterization of the Interaction between Hepatic Glucokinase and Its Regulatory Protein
- (2008) Oliver Anderka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Newly identified loci that influence lipid concentrations and risk of coronary artery disease
- (2008) Cristen J Willer et al. NATURE GENETICS
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