Article
Medicine, Research & Experimental
Liu Kai-xin, Cheng Cheng, Li Rui, Shi Zheng-wei, Tan Wen-wen, Xu Peng
Summary: Long noncoding RNAs (lncRNAs) play crucial roles in cancer, with MAGI2-AS3 being a widely expressed lncRNA associated with cancer development and prognosis. Dysregulation of MAGI2-AS3 can affect cancer cell behaviors and treatment responses, making it a potential biomarker and therapeutic target for cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Chunjie Huang, Paniz Azizi, Masoud Vazirzadeh, Seyed Mohsen Aghaei-Zarch, Fatemehsadat Aghaei-Zarch, Jalaledin Ghanavi, Poopak Farnia
Summary: Cancer is a complex disease with diverse factors. DNA methylation and dysregulation of non-coding RNAs play critical roles in cancer progression. Understanding the interplay between DNMT3B and ncRNAs provides insights into tumorigenesis and potential therapeutic interventions.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Meng-Ping Jiang, Wen-Xiu Xu, Jun-Chen Hou, Qi Xu, Dan-Dan Wang, Jin-Hai Tang
Summary: circRNAs are a unique family of noncoding RNAs that can regulate multiple biological processes and play a crucial role in the carcinogenesis and development of cancers by sponging miRNAs. In addition to sponging miRNAs, circRNAs also interact with RBPs to exert their functions, but studies on the underlying mechanisms and roles in different cancers are limited.
Review
Medicine, Research & Experimental
Mansour Almouh, Ehsan Razmara, Amirreza Bitaraf, Mohammad H. Ghazimoradi, Zuhair Mohammad Hassan, Sadegh Babashah
Summary: This study explores the role of circRNAs in regulating cell signaling pathways, particularly in tumorigenesis, providing important insights for identifying cancer therapeutic targets.
Review
Biochemistry & Molecular Biology
Anna L. Gharibyan, Sanduni Wasana Jayaweera, Manuela Lehmann, Intissar Anan, Anders Olofsson
Summary: Examined the anti-amyloid properties of endogenous proteins, which can interfere with amyloid formation and have clinical impact, providing potential therapeutic strategies.
Review
Immunology
Xuan Wu, Wenping Song, Cheng Cheng, Ziyang Liu, Xiang Li, Yu Cui, Yao Gao, Ding Li
Summary: Three isoforms of RAS gene, KRAS, NRAS, and HRAS, are the most mutated family of small GTPases in cancer. While targeted immunotherapies have improved the survival of patients with non-KRAS-mutant cancer, RAS-mutant cancers still have a poor prognosis due to their high aggressiveness. However, recent advances in the use of allele-specific covalent inhibitors have led to the development of effective pharmacological interventions against RAS-mutant cancer, such as Sotorasib (AMG510) for KRAS-G12C mutant NSCLC. This review summarizes the progress and promise of small-molecule inhibitors in clinical trials to improve the prognosis of tumors with RAS mutations.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Guoping Li, Aidan C. Manning, Alex Bagi, Xinyu Yang, Priyanka Gokulnath, Michail Spanos, Jonathan Howard, Patricia P. Chan, Thadryan Sweeney, Robert Kitchen, Haobo Li, Brice D. Laurent, Sary F. Aranki, Maria Kontaridis, Louise C. Laurent, Kendall Van Keuren-Jensen, Jochen Muehlschlegel, Todd M. Lowe, Saumya Das
Summary: The study highlights the crucial role of transfer RNA-derived small RNAs in different stress responses and introduces a new sequencing technique for generating a comprehensive abundance landscape of cellular and extracellular tDRs. It also reveals that extracellular tDRs have distinct fragmentation signatures which are better indicators of different stress responses than miRNAs.
Review
Cell Biology
Manjima Chatterjee, Pragasam Viswanathan
Summary: Long noncoding RNAs (lncRNAs) play significant roles in human malignancies, regulating cell survival or apoptosis and interacting closely with the p53 network and apoptosis pathways. They may serve as potential therapeutic targets or diagnostic/prognostic markers.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Yunfei Deng, Xiaochen Zeng, Yifei Lv, Zhiyuan Qian, Peijie Guo, Yi Liu, Shaoliang Chen
Summary: A circular RNA molecule, circCDYL2, and its protein product, Cdyl2-60aa, are significantly increased in rat heart muscle cells after myocardial infarction, promoting the death of heart muscle cells. Cdyl2-60aa enhances the stability of apoptotic protease activating factor-1 (APAF1) by blocking its ubiquitination by heat shock protein 70 (HSP70).
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Genetics & Heredity
Ibrahim Bozgeyik
Summary: T-UCRs are a novel family of non-coding RNAs which are completely conserved across human, mouse, and rat genomes. They are believed to be potential predisposing biomarkers for cancer development and may play a role in the malignant transformation of human tumors. Further research is needed to fully understand the functions and fate of T-UCRs in human cancers.
Article
Multidisciplinary Sciences
Christy Hong, Michael Schubert, Andrea E. Tijhuis, Marta Requesens, Maurits Roorda, Anouk van den Brink, Lorena Andrade Ruiz, Petra L. Bakker, Tineke van der Sluis, Wietske Pieters, Mengting Chen, Rene Wardenaar, Bert van der Vegt, Diana C. J. Spierings, Marco de Bruyn, Marcel A. T. M. van Vugt, Floris Foijer
Summary: Chromosomal instability (CIN) drives cancer cell evolution, metastasis, and therapy resistance. This study reveals that the inactivation of cGAS-STING signaling selectively impairs the survival of triple-negative breast cancer cells with CIN. Furthermore, blockade of IL-6 signaling using tocilizumab selectively impairs the growth of triple-negative breast cancer cells with CIN.
Review
Genetics & Heredity
Di Wu, Rongfei Li, Jingyu Liu, Changcheng Zhou, Ruipeng Jia
Summary: Intricate genetic mutations promote cancer progression, and LINC00467 is an upregulated long noncoding RNA that plays a significant role in various types of cancers. Overexpression of LINC00467 is associated with increased cell chemoresistance, proliferation, migration, invasion, and poor clinical prognosis.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Antonella Antignani, Maria Teresa Bilotta, Jacob S. Roth, Daniel J. Urban, Min Shen, Matthew D. Hall, David FitzGerald
Summary: A study found that IAPs are a barrier to the efficacy of immunotoxin treatment, which can be overcome with combination treatments that include Smac mimetics.
Article
Cell Biology
Jin-Yu Liu, Ya-Jing Chen, Huan-Hui Feng, Zhan-Li Chen, Yun-Long Wang, Jin-E Yang, Shi-Mei Zhuang
Summary: The study reveals that SNHG17 interacts with LRPPRC to enhance c-Myc expression, accelerate G1/S transition and cell proliferation, promoting tumor growth. High levels of SNHG17 or LRPPRC are associated with lower survival rates in HCC patients.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Medicinal
Dexiang Hua, Xiaoxing Wu
Summary: SUMOylation is a key post-translational modification process that is essential for normal cellular functions. Dysregulation of SUMOylation is associated with various diseases, and small-molecular inhibitors targeting this pathway have been discovered.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Shaopeng Liu, Tao Dong, Yupeng Shi, Hui Luo, Xianmin Xue, Yijin Zhu, Xiangping Wang, Biaoluo Wang, Shuhui Liang, Yanglin Pan, Xuegang Guo, Kaichun Wu
Summary: The water exchange method improved the total enteroscopy rate and increased the intubation depth during SBE. The use of water exchange did not increase the complications of enteroscopy.
Review
Gastroenterology & Hepatology
Jian Wan, Xuan Wang, Yujie Zhang, Min Chen, Min Wang, Kaichun Wu, Jie Liang
Summary: This systematic review and meta-analysis focused on the incidence and risk factors for advanced neoplasia in inflammatory bowel disease (IBD) patients with indefinite for dysplasia (IND) and low-grade dysplasia (LGD). The pooled incidences of advanced neoplasia in IND and LGD patients were found to be similar, indicating the need for rigorous surveillance. Risk factors for advanced neoplasia included primary sclerosing cholangitis, aneuploidy, and other factors. Further research is needed to validate these findings.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Correction
Gastroenterology & Hepatology
S. Liu, T. Dong, Y. Shi
Article
Gastroenterology & Hepatology
Leilei Fang, Han Gao, Xiang Gao, Wei Wu, Yinglei Miao, Hongjie Zhang, Bayasi Guleng, Hu Zhang, Yufang Wang, Mingsong Li, Hong Yang, Jie Liang, Qian Cao, Jun Shen, Zhihua Ran, Kaichun Wu, Jiaming Qian, Minhu Chen, Zhanju Liu
Summary: The risk of ischemic heart disease is higher in patients with inflammatory bowel disease (IBD), especially in young female patients. C-reactive protein (CRP), plasma fibrinogen levels, and neutrophil count in the peripheral blood may be potential predictors associated with the occurrence of ischemic heart disease in patients with IBD.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Clinical Neurology
Xuan Wang, Jian Wan, Min Wang, Yujie Zhang, Kaichun Wu, Fang Yang
Summary: This study demonstrates an association between multiple sclerosis (MS) and inflammatory bowel disease (IBD), with patients with MS having a higher risk of developing IBD and patients with IBD having a higher risk of developing MS.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xueli Chen, Xinyu Wang, Tianyu Yan, Yun Zheng, Honghao Cao, Feng Ren, Xu Cao, Xiangfeng Meng, Xiaojian Lu, Shuhui Liang, Kaichun Wu
Summary: By optimizing the structural parameters of fiber endoscope and imaging parameters for data acquisition, we developed a CLE system with a sensitivity at submicrocurie level. These results support the possibility that this technology can clinically detect early tumors within 1 minute.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Cell Biology
Min Deng, Christian F. Guerrero-Juarez, Xiaole Sheng, Jiuzhi Xu, Xi Wu, Kai Yao, Mengzhen Li, Xu Yang, Guilin Li, Jintao Xiao, Xiaowei Liu, Kaichun Wu, Fazheng Ren, Qing Nie, Maksim Plikus, Zhengquan Yu, Cong Lv
Summary: This study reveals that mesenchymal cells (MCs) surrounding the intestine can sense diet changes and modulate the function of intestinal stem cells (ISCs) through the secretion of IGF1. MCs play a critical role in maintaining the proliferation of ISC and progenitor cells, and these findings may provide a novel therapeutic target for gut diseases.
Article
Gastroenterology & Hepatology
Qian Cao, Chunxiao Chen, Xiang Gao, Yan Chen, Naizhong Hu, Jie Liang, Kaichun Wu
Summary: Research shows that ustekinumab is more effective in treating Crohn's disease than anti-tumor necrosis factor treatment for patients who did not respond to previous treatment. The remission rates of ustekinumab are superior to those in the UNITI-1 study.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Microbiology
Jian Wan, Yujie Zhang, Wenfang He, Zuhong Tian, Junchao Lin, Zhenzhen Liu, Yani Li, Min Chen, Shuang Han, Jie Liang, Yongquan Shi, Xuan Wang, Lei Zhou, Ying Cao, Jiayun Liu, Kaichun Wu
Summary: Patients with ulcerative colitis (UC) are at a higher risk of developing Clostridioides difficile infection (CDI), but the gut microbial structure and metabolites in UC and CDI patients have been poorly studied. This study identifies significant differences in gut microbiota and metabolites between UC and CDI patients compared to those with UC alone.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
Hong Yang, Huimin Zhang, Wei Liu, Bei Tan, Tao Guo, Xiang Gao, Rui Feng, Kaichun Wu, Qian Cao, Zhihua Ran, Zhanju Liu, Naizhong Hu, Liangru Zhu, Yamin Lai, Congling Wang, Wei Han, Jiaming Qian
Summary: This study established a scoring model for differentiating CD and UPIL based on clinical symptoms, endoscopic and imaging features, which showed high accuracy and discriminative ability.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Chenwen Cai, Juntao Lu, Lijie Lai, Dongjuan Song, Jun Shen, Jinlu Tong, Qing Zheng, Kaichun Wu, Jiaming Qian, Zhihua Ran
Summary: The current status of drug therapy and monitoring for inflammatory bowel disease (IBD) in Asia shows both similarities and differences. Improvements in IBD management in Asia require Asian recommendations, IBD specialist teams, and the practice of therapeutic drug monitoring.
INTESTINAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Joseph J. Y. Sung, Han-Mo Chiu, David Lieberman, Ernst J. Kuipers, Matthew D. Rutter, Finlay Macrae, Khay-Guan Yeoh, Tiing Leong Ang, Vui Heng Chong, Sneha John, Jingnan Li, Kaichun Wu, Simon S. M. Ng, Govind K. Makharia, Murdani Abdullah, Nozomu Kobayashi, Masau Sekiguchi, Jeong-Sik Byeon, Hyun-Soo Kim, Susan Parry, Patricia Anne Cabral-Prodigalidad, Deng-Chyang Wu, Suparkij Khomvilai, Rashid N. Lui, Sunny Wong, Yu-Min Lin, E. Dekker
Summary: The Asia-Pacific Working Group on Colorectal Cancer Screening has updated their recommendations on screening methods, age for screening, and surveillance for individuals with a family history of CRC or advanced adenoma based on the most recent studies in the region.
Article
Immunology
Ruqi Chang, Jieteng Chen, Zhaopeng Zhong, Yiyuan Li, Kaichun Wu, Hao Zheng, Yunsheng Yang
Summary: Patients with inflammatory bowel disease often experience cognitive impairment, but the underlying mechanism is unclear. In this study, researchers exposed honeybees to two different strains of E.coli and observed that the IBD-associated strain induced enteritis-like manifestations, cognitive behavioral modifications, increased gut permeability, and shortened lifespan in honeybees. The strain also altered the levels of certain substances in the honeybee gut and affected gene expression in the honeybee brain. This study suggests that honeybees can serve as a potential model for studying the microbiota-gut-brain interaction in IBD.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Yue Yin, Jian Wan, Jingmin Yu, Kaichun Wu
Summary: This review summarizes the molecular pathogenesis of colitis-associated colorectal cancer (CAC) from the aspects of immunity, genetics, and intestinal microecology, and it points out the potential mechanisms worthy of further study. It highlights the complexity of the inflammation process to cancer and the dual effects of inflammatory mediators in order to provide inspiration for finding effective biomarkers or targets to make CAC more predictable and treatable.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Jian Wan, Xuan Wang, Yujie Zhang, Xianmin Xue, Hui Jia, Min Wang, Jie Liang, Kaichun Wu
Summary: This study aimed to assess the association between cumulative inflammatory burden (CIB) and disease extension in distal UC patients and develop a quantified indicator of CIB. The study found that TA-MES is a good indicator of CIB and is independently associated with increased disease extension in distal UC patients.
GASTROENTEROLOGY REPORT
(2022)
