Targeting the Notch signaling pathway in autoimmune diseases

Notch3 Inhibition in Myelin-Reactive T Cells Down-Regulates Protein Kinase C  and Attenuates Experimental Autoimmune Encephalomyelitis

(2014) M. Jurynczyk et al.   JOURNAL OF IMMUNOLOGY

Notch1 Signaling and Regulatory T Cell Function

(2014) N. Asano et al.   JOURNAL OF IMMUNOLOGY

The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia

(2011) Teresa Palomero et al.   CELL CYCLE

Inhibition of gamma-secretase affects proliferation of leukemia and hepatoma cell lines through Notch signaling

(2010) Saipin Suwanjunee et al.   ANTI-CANCER DRUGS

Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura

(2009) Daoxin Ma et al.   ANNALS OF HEMATOLOGY

Rituximab is effective in the treatment of refractory ophthalmic Wegener's granulomatosis

(2009) Simon R. J. Taylor et al.   ARTHRITIS AND RHEUMATISM

Pain and rheumatology: Thinking outside the joint

(2009) Daniel J. Clauw et al.   ARTHRITIS AND RHEUMATISM

B-cell depletion in autoimmune diseases

(2009) Renato Guzman Moreno   AUTOIMMUNITY REVIEWS

Gene therapy in autoimmune diseases: Challenges and opportunities

(2009) Patrick S.C. Leung et al.   AUTOIMMUNITY REVIEWS

Cross-Talk Between Notch and EGFR Signaling in Human Breast Cancer Cells

(2009) Jianjian Dai et al.   CANCER INVESTIGATION

DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency

(2009) Timothy Hoey et al.   Cell Stem Cell

Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis

(2009) Michael Gersemann et al.   DIFFERENTIATION

Notch signaling contributes to the pathogenesis of human osteosarcomas

(2009) F. Engin et al.   HUMAN MOLECULAR GENETICS

The weight of interleukin-6 in B cell-related autoimmune disorders

(2009) Pierre Youinou et al.   JOURNAL OF AUTOIMMUNITY

The etiology of autoimmune thyroid disease: A story of genes and environment

(2009) Yaron Tomer et al.   JOURNAL OF AUTOIMMUNITY

Jagged1 Suppresses Collagen-Induced Arthritis by Indirectly Providing a Negative Signal in CD8+ T Cells

(2009) M. Kijima et al.   JOURNAL OF IMMUNOLOGY

Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial

(2009) James B Bussel et al.   LANCET

Down-regulation of Notch-1 increases co-cultured Jurkat cell sensitivity to chemotherapy

(2009) Dongmei Guo et al.   LEUKEMIA & LYMPHOMA

Requirement of Notch activation during regeneration of the intestinal epithelia

(2008) Ryuichi Okamoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Profile of Th17 cytokines (IL-17, TGF-β, IL-6) and Th1 cytokine (IFN-γ) in patients with immune thrombocytopenic purpura

(2008) Daoxin Ma et al.   ANNALS OF HEMATOLOGY

Metabolic control of T cell activation and death in SLE

(2008) David Fernandez et al.   AUTOIMMUNITY REVIEWS

Transcriptional regulation of IL-2 in health and autoimmunity

(2008) José C. Crispín et al.   AUTOIMMUNITY REVIEWS

Altered B-cell signaling in lupus

(2008) Kui Liu et al.   AUTOIMMUNITY REVIEWS

Induction of CCL2 by siMAML1 through upregulation of TweakR in melanoma cells

(2008) Shijun Kang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura

(2008) J. Yu et al.   BLOOD

Emerging role of Notch in stem cells and cancer

(2008) Zhiwei Wang et al.   CANCER LETTERS

Cross-talk between Notch and the Estrogen Receptor in Breast Cancer Suggests Novel Therapeutic Approaches

(2008) P. Rizzo et al.   CANCER RESEARCH

Notch Signaling Specifies Megakaryocyte Development from Hematopoietic Stem Cells

(2008) Thomas Mercher et al.   Cell Stem Cell

Notch Signaling in Leukemias and Lymphomas

(2008) Franziska Jundt et al.   CURRENT MOLECULAR MEDICINE

Possible Mechanisms of Action of NSAIDs and Related Compounds that Modulate γ - Secretase Cleavage

(2008) Thomas Kukar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Microbial Influences in Inflammatory Bowel Diseases

(2008) R. Balfour Sartor   GASTROENTEROLOGY

In vitro validation of  -secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia

(2008) K. De Keersmaecker et al.   HAEMATOLOGICA

Will hematopoietic stem cell transplantation cure human autoimmune diseases?

(2008) Alberto M. Marmont   JOURNAL OF AUTOIMMUNITY

Notch signaling inhibits the growth of the human chronic myeloid leukemia cell line K562

(2008) Dan-Dan Yin et al.   LEUKEMIA RESEARCH

Notch and BCR signaling synergistically promote the proliferation of Raji B-lymphoma cells

(2008) Fei He et al.   LEUKEMIA RESEARCH

Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines

(2008) Dongmei Guo et al.   LEUKEMIA RESEARCH

Defects in Notch1 upregulation upon activation of T Cells from patients with systemic lupus erythematosus are related to lupus disease activity

(2008) P Sodsai et al.   LUPUS

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE

Targeting Notch signaling in autoimmune and lymphoproliferative disease

(2007) D. T. Teachey et al.   BLOOD

Overcoming failure to repair demyelination in EAE: γ-secretase inhibition of Notch signaling

(2007) Maciej Jurynczyk et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES