Article
Cell Biology
Ling Zhang, Jieying Wu, Yashu Feng, Bijay Khadka, Zhigang Fang, Jiaming Gu, Baoqiang Tang, Ruozhi Xiao, Guangjin Pan, Jia-Jun Liu
Summary: Leukemia-initiating cells in T-ALL patients exhibit overexpression of beta-catenin, leading to therapy resistance and subsequent shift in dependency towards Notch signaling pathway. These two pathways mutually compensate each other to maintain stem cell phenotype in T-ALL.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Gautam Borthakur, Giovanni Martinelli, Emmanuel Raffoux, Patrice Chevallier, Jorg Chromik, Andrew Lithio, Claire L. Smith, Eunice Yuen, Gerard Joseph Oakley, Karim A. Benhadji, Daniel J. DeAngelo
Summary: The study included 36 patients with T-ALL (n = 31, 86.1%) or T-LBL (n = 5, 13.9%) who received treatment with Crenigacestat and dexamethasone, with the maximum tolerated dose being 75 mg of Crenigacestat plus 24 mg of dexamethasone daily. Overall, Crenigacestat demonstrated limited clinical activity in adult patients with relapsed/refractory T-ALL/T-LBL.
Article
Medicine, Research & Experimental
Huizhong Xiong, Maicol Mancini, Michael Gobert, Shiqian Shen, Glaucia C. Furtado, Sergio A. Lira, Christopher N. Parkhurst, Veronique Garambois, Muriel Brengues, Carlos E. Tadokoro, Thomas Trimarchi, Gonzalo Gomez-Lopez, Amartya Singh, Hossein Khiabanian, Sonia Minuzzo, Stefano Indraccolo, Camille Lobry, Iannis Aifantis, Daniel Herranz, Juan J. Lafaille, Antonio Maraver
Summary: The study revealed that Notch pathway activity in T-ALL depends on DLL4 signaling, while the spleen plays a major role in DLL4-driven T-ALL.
Review
Biochemistry & Molecular Biology
Parveen Shiraz, Waqas Jehangir, Vaibhav Agrawal
Summary: T-cell acute lymphoblastic leukemia (T-ALL) is a rare but aggressive leukemia with CDKN2A/CDKN2B and NOTCH1 being the most common mutated genes. While outcomes for de-novo disease are improving, patients with relapsed and refractory T-ALL have poor prognosis. New targeted therapies show potential to further improve outcomes, and the role of allogeneic stem cell transplant is evolving with the increased use of pediatric-inspired regimens.
Review
Biochemistry & Molecular Biology
Martina Del Gaizo, Ilaria Sergio, Sara Lazzari, Samantha Cialfi, Maria Pelullo, Isabella Screpanti, Maria Pia Felli
Summary: This article reviews the literature on the regulatory role of miRNAs in the immune response of T-ALL, focusing on their roles in Natural Killer, T, T-regulatory, and Myeloid-derived suppressor cells. A better understanding of this molecular crosstalk may provide the basis for the development of potential immunotherapeutic strategies in the field of leukemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Matteo D'Addona, Valentina Giudice, Luca Pezzullo, Giuseppe Ciancia, Carlo Baldi, Marisa Gorrese, Angela Bertolini, Annapaola Campana, Lucia Fresolone, Paola Manzo, Pio Zeppa, Bianca Serio, Carmine Selleri
Summary: Richter's syndrome is a pathological transformation of CLL into more aggressive diseases, most commonly diffuse large B-cell lymphoma. This study describes two rare cases of Richter's syndrome and discusses the increased risk associated with novel targeted therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Yigeng Cao, Yadan Liu, Rongli Zhang, Weihua Zhai, Qiaoling Ma, Jialin Wei, Donglin Yang, Aiming Pang, Yi He, Xin Chen, Erlie Jiang, Sizhou Feng, Mingzhe Han
Summary: This is a case report on cardiac involvement in hematological malignancies, presenting a 42-year-old woman with a history of allo-HSCT and CAR T-cell therapy, who developed cardiac mass and myocardial infiltration. Despite treatment, the patient died of multiple organ failure. This report provides supporting data for the early diagnosis and immediate treatment of patients with cardiac involvement.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Robert Chiesa, Christos Georgiadis, Farhatullah Syed, Hong Zhan, Annie Etuk, Soragia Athina Gkazi, Roland Preece, Giorgio Ottaviano, Toni Braybrook, Jan Chu, Agnieszka Kubat, Stuart Adams, Rebecca Thomas, Kimberly Gilmour, David O'Connor, Ajay Vora, Waseem Qasim
Summary: Base editing technique has been used to inactivate genes and treat relapsed childhood T-cell leukemia with promising results.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Zhen Li, Binglei Zhang, Xinxin Fan, Ruirui Gui, Fengkuan Yu, Juan Wang, Yanli Zhang, Keshu Zhou, Yanyan Liu, Yufu Li, Jing Ding, Yongping Song, Jian Zhou
Summary: Hematopoietic stem cell transplantation (HSCT) is an effective treatment for T-cell lymphoblastic lymphoma/leukemia (T-LBL). The efficacy of autologous HSCT (auto-HSCT) and allogeneic HSCT (allo-HSCT) was comparable, but allo-HSCT had a significantly higher non-relapse mortality rate. First complete remission and absence of mediastinal invasion were independent factors affecting prognosis. Unrelated donors and haploidentical donors had higher non-relapse mortality rates compared to auto-HSCT, while matched sibling donors had a similar outcome to auto-HSCT.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Giulia Veltri, Federica Lovisa, Giuliana Cortese, Marta Pillon, Elisa Carraro, Simone Cesaro, Massimo Provenzi, Salvatore Buffardi, Samuela Francescato, Alessandra Biffi, Barbara Buldini, Valentino Conter, Valentina Serafin, Lara Mussolin
Summary: T-cell lymphoblastic lymphoma (T-LBL) and lymphoblastic leukemia (T-ALL) share common features but have different phosphoproteomic profiles. A proteomic signature of six proteins can distinguish stage IV T-LBL from T-ALL, and AKT hyperphosphorylation alone can distinguish stage IV T-LBL from both T-ALL and stage III T-LBL.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Kimberly G. Laffey, Robert J. Stiles, Melissa J. Ludescher, Tessa R. Davis, Shariq S. Khwaja, Richard J. Bram, Peter J. Wettstein, Venkataraman Ramachandran, Christopher A. Parks, Edwin E. Reyes, Alejandro Ferrer, Jenna M. Canfield, Cory E. Johnson, Richard D. Hammer, Diana Gil, Adam G. Schrum
Summary: During normal T cell development, a low-frequency population of early all TCR+ DN cells is present, which requires CD3δ for their generation/detection. These cells can respond to MHC and display coreceptor-independent MHC reactivity. It has been observed that these cells are susceptible to T-ALL transformation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Hematology
Cedric S. Tremblay, Jesslyn Saw, Jacqueline A. Boyle, Katharina Haigh, Veronique Litalien, Hannah McCalmont, Kathryn Evans, Richard B. Lock, Stephen M. Jane, Jody J. Haigh, David J. Curtis
Summary: Interleukin-7 (IL-7) is important for the growth and resistance to chemotherapy of T-cell acute lymphoblastic leukemia (T-ALL), especially the early T-cell precursor subtype (ETP-ALL). Signal transducer and activator of transcription (STAT5) is universally activated in ETP-ALL and plays a crucial role in its development. Inhibition of STAT5 is necessary to block the supportive signals provided by IL-7 and eradicate leukemia stem cells (LSCs).
Review
Medicine, General & Internal
Pauline Brice, Eric de Kerviler, Jonathan W. Friedberg
Summary: Classical Hodgkin lymphoma is a relatively common lymphoma that is generally considered highly curable with standard first-line chemotherapy and radiotherapy, although some patients may not be cured or may experience late toxic effects leading to premature death. Recent changes in the gold standard of chemotherapy, now often including immunotherapy in relapse settings, have further impacted treatment outcomes.
Article
Oncology
Felix Korell, Maria-Luisa Schubert, Tim Sauer, Anita Schmitt, Patrick Derigs, Tim Frederik Weber, Paul Schnitzler, Carsten Mueller-Tidow, Peter Dreger, Michael Schmitt
Summary: CAR-T cell therapy is effective in treating relapsed/refractory acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL) patients, but infections resulting from lymphodepletion or CAR-T cell therapy can lead to severe and potentially life-threatening complications. Identification and treatment of infections are crucial in these immunocompromised patients, with standardized prophylaxis and supportive therapy being necessary to reduce morbidity and mortality. Infections are common in CAR-T cell treated patients, but overall serious complications are rare, highlighting the importance of fast and appropriate management in this vulnerable patient population.
Article
Oncology
Amber Gibson, Adriana Trabal, David McCall, Sajad Khazal, Laurie Toepfer, Donna H. Bell, Michael Roth, Kris M. Mahadeo, Cesar Nunez, Nicholas J. Short, Courtney DiNardo, Marina Konopleva, Ghayas C. Issa, Farhad Ravandi, Nitin Jain, Gautam Borthakur, Hagop M. Kantarjian, Elias Jabbour, Branko Cuglievan
Summary: This study retrospectively reviewed the safety and efficacy of Venetoclax in pediatric and young adult patients with relapsed or refractory acute lymphoblastic leukemia (ALL) or lymphoma (LBL). The results showed that Venetoclax is safe and effective to use in pediatric patients with ALL/LBL and should be considered in both the relapsed and upfront settings.
Review
Biochemistry & Molecular Biology
Marietta Herrmann, Klaus Engelke, Regina Ebert, Sigrid Mueller-Deubert, Maximilian Rudert, Fani Ziouti, Franziska Jundt, Dieter Felsenberg, Franz Jakob
Article
Medicine, General & Internal
David Cordas dos Santos, Nicole Erickson, Lars Gerland, Franziska Jundt, Sebastian Theurich
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2020)
Article
Engineering, Biomedical
Maximilian Rummler, Fani Ziouti, Alice L. Bouchard, Andreas Brandl, Georg N. Duda, Bjarne Bogen, Andreas Beilhack, Maureen E. Lynch, Franziska Jundt, Bettina M. Willie
Summary: This study found that mechanical loading can enhance bone mass, prevent osteolytic destruction, and inhibit the growth and dissemination of multiple myeloma cells in mice. These findings suggest that physical stimuli may serve as an anabolic treatment for osteolytic bone destruction in patients with multiple myeloma.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Andria Constantinou, Katarzyna Polak-Witka, Marios Tomazou, Anastasis Oulas, Varvara Kanti, Rolf Schwarzer, Johannes Helmuth, Anke Edelmann, Ulrike Blume-Peytavi, George M. Spyrou, Annika Vogt
Summary: This study investigated the bacterial composition of scalp skin and hair follicles in patients with FFA, LPP, AAc, and healthy individuals, finding dysbiosis in the bacterial communities of FFA and LPP patients and observed molecular signals associated with increased expression in lesional sites. This suggests the need for further research on the role of exogenous factors and molecular interactions in disease onset and propagation.
Article
Biochemistry & Molecular Biology
Fani Ziouti, Maximilian Rummler, Beatrice Steyn, Tobias Thiele, Anne Seliger, Georg N. Duda, Bjarne Bogen, Bettina M. Willie, Franziska Jundt
Summary: Research showed that the Bruton's tyrosine kinase inhibitor CC-292 did not significantly enhance bone anabolism or rescue bone mass compared to mechanical loading alone in the treatment of myeloma bone disease. Novel anti-myeloma and anti-resorptive strategies in combination with physical stimuli are needed to improve the treatment of MMBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Terry C. Jones, Guido Biele, Barbara Muhlemann, Talitha Veith, Julia Schneider, Joern Beheim-Schwarzbach, Tobias Bleicker, Julia Tesch, Marie Luisa Schmidt, Leif Erik Sander, Florian Kurth, Peter Menzel, Rolf Schwarzer, Marta Zuchowski, Joerg Hofmann, Andi Krumbholz, Angela Stein, Anke Edelmann, Victor Max Corman, Christian Drosten
Summary: In a study of SARS-CoV-2 cases in Germany, it was found that younger subjects had lower viral loads but higher cell culture replication probabilities compared to older subjects. Additionally, 8% of subjects had viral loads above 10(9) copies per swab, with a third of them being presymptomatic, asymptomatic, or mildly symptomatic individuals with a mean age of 37.6 years. The B.1.1.7 lineage infections had a higher viral load and cell culture replication probability than non-B.1.1.7 subjects.
Article
Immunology
Rolf Schwarzer, Sabine D. Freys, Nick Neuwinger, Nina Beikert, Bettina Eberspaecher, Anke Edelmann, Marta Zuchowski, Inga Slothouwer, Angela Stein, Kathrin Theil, Peter Menzel, Jorg Hofmann
Summary: A study on a COVID-19 outbreak in a senior citizen home in Bremen, Germany, found that partial vaccination prevented severe cases among the residents, highlighting the high effectiveness of even a single vaccine dose, but also warning about asymptomatic individuals potentially being carriers.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Dermatology
Joachim W. Fluhr, Peter Menzel, Rolf Schwarzer, Benjamin Kaestle, Michaela Arens-Corell, Lina Praefke, Nikolai K. Tsankov, Dessyslava G. Nikolaeva, Laurent Misery, Razvigor Darlenski
Summary: This study investigated the effects of different cosmetic lotions on skin microbiome and skin physiology after mild tape stripping. The results showed that the lotions accelerated the recovery of the microbiome and increased stratum corneum hydration. The composition of the lotion and induced repair mechanism may be responsible for the accelerated normalization of the microbiome.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Oliver Wagendorf, Peter Menzel, Rolf Schwarzer, Norbert Neckel, Saskia Preissner, Max Heiland, Susanne Nahles
Summary: This study investigated the use of sonication as a new tool in microbiological probing of dental infections. The results showed that sonication yielded a higher number of bacterial sequencing reads and identified more operational taxonomic units (OTUs) compared to the standard procedures. It also found that actinomycetales were more abundant in sonication fluid samples. Additionally, due to the high rates of antibiotic resistance, a more targeted antibiotic therapy is favored, with levofloxacin being a potential alternative to amoxicillin + clavulanate in patients with penicillin allergy.
Article
Oncology
Michael Mendes Wefelnberg, Timo Niels, Udo Holtick, Franziska Jundt, Christoph Scheid, Freerk T. Baumann
Summary: This study examines the feasibility, adherence, and efficacy of exercise therapy in multiple myeloma (MM) patients based on real-life data. The results indicate that exercising MM patients under real-life therapy circumstances is safe, feasible, and has some efficacy. Further research is needed to explore the barriers to exercise and improvements in questionnaire scores.
SUPPORTIVE CARE IN CANCER
(2022)
Letter
Oncology
Marietheres Evers, Martin Schreder, Thorsten Stuehmer, Franziska Jundt, Regina Ebert, Tanja Nicole Hartmann, Michael Altenbuchinger, Martina Rudelius, Martin Kuric, Wyonna Darleen Rindt, Torsten Steinbrunn, Christian Langer, Sofia Catalina Heredia-Guerrero, Hermann Einsele, Ralf Christian Bargou, Andreas Rosenwald, Ellen Leich
BLOOD CANCER JOURNAL
(2023)
Letter
Oncology
Daniela Simone Maichl, Julius Arthur Kirner, Susanne Beck, Wen-Hui Cheng, Melanie Krug, Martin Kuric, Carsten Patrick Ade, Thorsten Bischler, Franz Jakob, Dirk Hose, Anja Seckinger, Regina Ebert, Franziska Jundt
BLOOD CANCER JOURNAL
(2023)
Article
Oncology
Jan-Peter Grunz, Andreas Steven Kunz, Freerk T. Baumann, Dirk Hasenclever, Malte Maria Sieren, Stefan Heldmann, Thorsten Alexander Bley, Hermann Einsele, Stefan Knop, Franziska Jundt
Summary: This study used CT scans to examine the response of osteolytic manifestations in patients with multiple myeloma after induction therapy. The results showed that most lesions decreased in size and exhibited trabecular sclerosis, indicating that CT scans can be used as a reliable method to evaluate treatment response.
Article
Dermatology
Katarzyna Polak-Witka, Andria Constantinou, Rolf Schwarzer, Johannes Helmuth, Alexandra Wiessner, Sabrina Hadam, Varvara Kanti, Fiorenza Rancan, Annette Andruck, Claudia Richter, Annette Moter, Anke Edelmann, Lidia Rudnicka, Ulrike Blume-Peytavi, Annika Vogt
Summary: Studies on anagen hair follicles have identified the presence of bacteria in the lower follicles, with Lawsonella clevelandensis, Staphylococcaceae, and Propionibacteriaceae being the most abundant. These findings suggest that the skin microbiome may play a role in hair cycling through its influence on the local immune system, particularly in relation to bacterial presence near follicular immune-privileged areas.
EUROPEAN JOURNAL OF DERMATOLOGY
(2021)
Article
Microbiology
Peter Menzel, Rolf Schwarzer, Johannes Helmuth, Inna Friesen
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2020)
