Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia

Role of Oxygen in Cancer: Looking Beyond Hypoxia

(2012) Miguel Lopez-Lazaro   Anti-Cancer Agents in Medicinal Chemistry

Developments in the therapeutic use of erythropoiesis stimulating agents

(2010) Wolfgang Jelkmann   BRITISH JOURNAL OF HAEMATOLOGY

Role of the hypoxia inducible factors HIF in iron metabolism

(2010) Carole Peyssonnaux et al.   CELL CYCLE

The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice

(2010) Michele M. Hickey et al.   JOURNAL OF CLINICAL INVESTIGATION

Erythropoiesis-Stimulating Agents — Time for a Reevaluation

(2010) Ellis F. Unger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic Manipulation of the HIF Hydroxylases

(2009) Simon Nagel et al.   ANTIOXIDANTS & REDOX SIGNALING

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Molecular mechanisms of pulmonary hypertension

(2009) Pinar Yildiz   CLINICA CHIMICA ACTA

Hypoxic Tumor Microenvironment and Cancer Cell Differentiation

(2009) Yuri Kim et al.   CURRENT MOLECULAR MEDICINE

HIF Prolyl 4-Hydroxylases and their Potential as Drug Targets

(2009) Johanna Myllyharju   CURRENT PHARMACEUTICAL DESIGN

HIF Prolyl-4-hydroxylase Interacting Proteins: Consequences for Drug Targeting

(2009) Roland Wenger et al.   CURRENT PHARMACEUTICAL DESIGN

Erythrocytosis-associated HIF-2α Mutations Demonstrate a Critical Role for Residues C-terminal to the Hydroxylacceptor Proline

(2009) Paul W. Furlow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of hypoxia in the hallmarks of human cancer

(2009) Kai Ruan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Application of a Proteolysis/Mass Spectrometry Method for Investigating the Effects of Inhibitors on Hydroxylase Structure

(2009) Christopher J. Stubbs et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation of angiogenesis by oxygen sensing mechanisms

(2009) Guo-Hua Fong   JOURNAL OF MOLECULAR MEDICINE-JMM

Healthcare Expenditure and Resource Utilization in Patients with Anaemia and Chronic Kidney Disease: A Retrospective Claims Database Analysis

(2009) Jay Wish et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

(2009) Peter Fraisl et al.   NATURE REVIEWS DRUG DISCOVERY

Erythropoietin and Tumor Angiogenesis

(2009) Domenico Ribatti   STEM CELLS AND DEVELOPMENT

Structure and Signaling Mechanism of Per-ARNT-Sim Domains

(2009) Andreas Möglich et al.   STRUCTURE

Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases

(2009) Rasheduzzaman Chowdhury et al.   STRUCTURE

Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology

(2008) Jennifer H. Dao et al.   ANALYTICAL BIOCHEMISTRY

Biochemical Characterization of Human Prolyl Hydroxylase Domain Protein 2 Variants Associated with Erythrocytosis

(2008) Melissa B. Pappalardi et al.   BIOCHEMISTRY

Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation

(2008) Christopher M. Tegley et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors

(2008) Mike Frohn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Genetic causes of erythrocytosis and the oxygen-sensing pathway

(2008) Frank S. Lee   BLOOD REVIEWS

A novel heterozygous HIF2AM535I mutation reinforces the role of oxygen sensing pathway disturbances in the pathogenesis of familial erythrocytosis

(2008) M. Martini et al.   HAEMATOLOGICA

Nuclear Oxygen Sensing: Induction of Endogenous Prolyl-hydroxylase 2 Activity by Hypoxia and Nitric Oxide

(2008) Utta Berchner-Pfannschmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The increase in pulmonary arterial pressure caused by hypoxia depends on iron status

(2008) Thomas G. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

Expanding chemical biology of 2-oxoglutarate oxygenases

(2008) Christoph Loenarz et al.   Nature Chemical Biology

PHD2Mutation and Congenital Erythrocytosis with Paraganglioma

(2008) Charline Ladroue et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Gain-of-Function Mutation in theHIF2AGene in Familial Erythrocytosis

(2008) Melanie J. Percy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disturbance in the HIF-1α pathway associated with erythrocytosis: Further evidences brought by frameshift and nonsense mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene

(2007) Maha Al-Sheikh et al.   BLOOD CELLS MOLECULES AND DISEASES

Gas phase reaction of substituted isoquinolines to carboxylic acids in ion trap and triple quadrupole mass spectrometers after electrospray ionization and collision-induced dissociation

(2007) Mario Thevis et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY