Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds

Cutting Edge: Autocrine TGF-  Sustains Default Tolerogenesis by IDO-Competent Dendritic Cells

(2014) M. L. Belladonna et al.   JOURNAL OF IMMUNOLOGY

Progression of Pancreatic Adenocarcinoma Is Significantly Impeded with a Combination of Vaccine and COX-2 Inhibition

(2014) P. Mukherjee et al.   JOURNAL OF IMMUNOLOGY

The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation

(2014) W. Chen et al.   JOURNAL OF IMMUNOLOGY

IDO recruits Tregs in melanoma

(2011) George Prendergast et al.   CELL CYCLE

Differential Regulation of Indoleamine-2,3-Dioxygenase (IDO) by HIV Type 1 Clade B and C Tat Protein

(2009) Thangavel Samikkannu et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes

(2009) M. D. Sharma et al.   BLOOD

Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

(2009) Feng Qian et al.   CANCER RESEARCH

Elevated Expression of Indoleamine 2,3-Dioxygenase (IDO) and Accumulation of Kynurenic Acid in the Pathogenesis of STZ-Induced Diabetic Cataract in Wistar Rats

(2009) Vangipurapu Rajani Kanth et al.   CURRENT EYE RESEARCH

Manipulation of indoleamine 2,3 dioxygenase; a novel therapeutic target for treatment of diseases

(2009) PH Tan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Indoleamine 2,3-dioxygenase in intestinal immunity and inflammation

(2009) Bobby J. Cherayil   INFLAMMATORY BOWEL DISEASES

Parameters of Soluble Immune Activation In Vivo Correlate Negatively With the Proliferative Capacity of Peripheral Blood Mononuclear Cells In Vitro in HIV-Infected Patients

(2009) Katharina Schroecksnadel et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Kynurenic Acid Triggers Firm Arrest of Leukocytes to Vascular Endothelium under Flow Conditions

(2009) Marita C. Barth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cacao extracts suppress tryptophan degradation of mitogen-stimulated peripheral blood mononuclear cells

(2009) M. Jenny et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Immunoregulatory Enzyme IDO Paradoxically Drives B Cell-Mediated Autoimmunity

(2009) G. N. Scott et al.   JOURNAL OF IMMUNOLOGY

Combined Effect of Antiretroviral Therapy and Blockade of IDO in SIV-Infected Rhesus Macaques

(2009) A. Boasso et al.   JOURNAL OF IMMUNOLOGY

Blockade of Indoleamine 2,3-Dioxygenase Protects Mice against Lipopolysaccharide-Induced Endotoxin Shock

(2009) I. D. Jung et al.   JOURNAL OF IMMUNOLOGY

Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens

(2009) Maneesh Mailankot et al.   LABORATORY INVESTIGATION

The Excitotoxin Quinolinic Acid Induces Tau Phosphorylation in Human Neurons

(2009) Abdur Rahman et al.   PLoS One

Kynurenines and oxidative status are independently associated with thrombomodulin and von Willebrand factor levels in patients with end-stage renal disease

(2009) Krystyna Pawlak et al.   THROMBOSIS RESEARCH

TGF-β and kynurenines as the key to infectious tolerance

(2009) Maria L. Belladonna et al.   TRENDS IN MOLECULAR MEDICINE

Targeting Indoleamine 2,3-dioxygenase (IDO) to Counteract Tumour- Induced ImmuneDysfunction: From Biochemistry to Clinical Development

(2009) S. Rutella et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer disease

(2008) Antonio Macchiarulo et al.   AMINO ACIDS

The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease

(2008) Krystyna Pawlak et al.   ATHEROSCLEROSIS

The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology

(2008) A. Curti et al.   BLOOD

IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism

(2008) Stefan Löb et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Inverse Correlation between Tumoral Indoleamine 2,3-Dioxygenase Expression and Tumor-Infiltrating Lymphocytes in Endometrial Cancer: Its Association with Disease Progression and Survival

(2008) K. Ino et al.   CLINICAL CANCER RESEARCH

Emerging concepts in CD8+ T regulatory cells

(2008) Jerry Y Niederkorn   CURRENT OPINION IN IMMUNOLOGY

T cells, B cells, and polarized immune response in the pathogenesis of fibrosis and systemic sclerosis

(2008) Carlo Chizzolini   CURRENT OPINION IN RHEUMATOLOGY

The concentration of kynurenine in rat model of asthma.

(2008) Iwona Kucharewicz et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Immunomodulatory effects of Turkish propolis: Changes in neopterin release and tryptophan degradation

(2008) Gozde Girgin et al.   IMMUNOBIOLOGY

Twelve immunotherapy drugs that could cure cancers

(2008) Martin A. ‘Mac’ Cheever   IMMUNOLOGICAL REVIEWS

Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells

(2008) Ilaria Marigo et al.   IMMUNOLOGICAL REVIEWS

Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape

(2008) Jessica B. Katz et al.   IMMUNOLOGICAL REVIEWS

Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase

(2008) Alberto Molano et al.   IMMUNOLOGY LETTERS

IDO: A double-edged sword for TH1/TH2 regulation

(2008) Hui Xu et al.   IMMUNOLOGY LETTERS

Deficiency of Indoleamine 2,3-Dioxygenase Enhances Commensal-Induced Antibody Responses and Protects against Citrobacter rodentium-Induced Colitis

(2008) L. Harrington et al.   INFECTION AND IMMUNITY

Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway

(2008) Helen J. Ball et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Indoleamine 2,3-dioxygenase–dependent tryptophan metabolites contribute to tolerance induction during allergen immunotherapy in a mouse model

(2008) Yousef A. Taher et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Curcumin Suppresses the Induction of Indoleamine 2,3-Dioxygenase by Blocking the Janus-activated Kinase-Protein Kinase Cδ-STAT1 Signaling Pathway in Interferon-γ-stimulated Murine Dendritic Cells

(2008) Young-Il Jeong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase–dependent mechanism

(2008) Olivier Manches et al.   JOURNAL OF CLINICAL INVESTIGATION

Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors

(2008) Sanjeev Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Indoleamine 2,3-Dioxygenase Inhibitory Analogues of the Sponge Alkaloid Exiguamine A

(2008) Gavin Carr et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure Based Development of Phenylimidazole-Derived Inhibitors of Indoleamine 2,3-Dioxygenase

(2008) Sanjeev Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expression of Indoleamine 2,3-Dioxygenase in Metastatic Pancreatic Ductal Adenocarcinoma Recruits Regulatory T Cells to Avoid Immune Detection

(2008) Agnes Witkiewicz et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host

(2008) T ZELANTE et al.   MICROBES AND INFECTION

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

(2008) Luigina Romani et al.   NATURE

Biomimetic synthesis of the IDO inhibitors exiguamine A and B

(2008) Matthew Volgraf et al.   Nature Chemical Biology

Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I

(2008) Tiziana Di Pucchio et al.   NATURE IMMUNOLOGY

Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder

(2008) Christine L. Miller et al.   NEUROCHEMISTRY INTERNATIONAL

Immune escape as a fundamental trait of cancer: focus on IDO

(2008) G C Prendergast   ONCOGENE

Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation

(2008) H. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis

(2008) C. Orabona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase

(2008) A. J. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Indoleamine 2,3‐dioxygenase activity associates with cardiovascular risk factors: The Health 2000 study

(2008) P. Niinisalo et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Nonimmune cells in inflammatory bowel disease: from victim to villain

(2008) Silvio Danese   TRENDS IN IMMUNOLOGY

Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality

(2007) L. K. Jasperson et al.   BLOOD

Toxicology and pharmacokinetics of 1-methyl-d-tryptophan: Absence of toxicity due to saturating absorption

(2007) Lee Jia et al.   FOOD AND CHEMICAL TOXICOLOGY