期刊
CURRENT OPINION IN IMMUNOLOGY
卷 20, 期 3, 页码 327-331出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2008.02.003
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- NEI NIH HHS [EY016664, EY005631, R24 EY016664-039002, R24 EY016664, R01 EY007641-19, R01 EY007641, R01 EY005631, R01 EY005631-22, EY007641] Funding Source: Medline
CD8(+) T regulatory cells (T regs) are elicited by unique antigen presenting cells during viral infections, by manipulation of costimulatory molecules, or in the development of tumors. CD8(+) T regs display antigen-specificity, which is most exquisitely manifested by the HLA-E-restricted cytolytic CD8(+) T regs in MS. There is evidence that some CD8(+) T regs also express organ specificity. In many cases, IFN-gamma is required for either the induction or expression of CD8(+) T regs. CD8(+) T regs can produce suppression directly by killing immune cells or indirectly by co-opting other cells to elaborate end-stage suppressive molecules such as TGF-beta, IL-10, and indoleamine dioxygenase (IDO).
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