Cisplatin: an old drug with a newfound efficacy – from mechanisms of action to cytotoxicity

The Role of Mannitol as a Nephroprotectant in Patients Receiving Cisplatin Therapy

(2012) K. P. Morgan et al.   ANNALS OF PHARMACOTHERAPY

Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update

(2012) Neife Aparecida Guinaim dos Santos et al.   ARCHIVES OF TOXICOLOGY

Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo

(2012) Benedikt Feuerecker et al.   CANCER BIOLOGY & THERAPY

Chemotherapy in gastroenteropancreatic (GEP) neuroendocrine carcinomas (NEC): A critical view

(2012) Nicola Fazio et al.   CANCER TREATMENT REVIEWS

Erythropoietin protects against cisplatin-induced nephrotoxicity by attenuating endoplasmic reticulum stress-induced apoptosis

(2012) Deyang Kong et al.   JOURNAL OF NEPHROLOGY

The effect of sodium thiosulfate on the metabolism of cis-platin in human plasma in vitro

(2012) Melani Sooriyaarachchi et al.   Metallomics

Curcumin reduces cisplatin-induced neurotoxicity in NGF-differentiated PC12 cells

(2012) Leonardo Meneghin Mendonça et al.   NEUROTOXICOLOGY

Free radicals and antioxidants: updating a personal view

(2012) Barry Halliwell   NUTRITION REVIEWS

Subcellular targets of cisplatin cytotoxicity: An integrated view

(2012) Sandra M. Sancho-Martínez et al.   PHARMACOLOGY & THERAPEUTICS

The comparison between weekly and three-weekly cisplatin delivered concurrently with radiotherapy for patients with postoperative high-risk squamous cell carcinoma of the oral cavity

(2012) Din-Li Tsan et al.   Radiation Oncology

An integrative view of the pathophysiological events leading to cisplatin nephrotoxicity

(2011) Penélope D. Sánchez-González et al.   CRITICAL REVIEWS IN TOXICOLOGY

A new dimension of FDG-PET interpretation: assessment of tumor biology

(2011) Thomas C. Kwee et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Abrogation of cisplatin-induced nephrotoxicity in mice by alpha lipoic acid through ameliorating oxidative stress and enhancing gene expression of antioxidant enzymes

(2011) Hesham A. El-Beshbishy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective Effect of Recombinant Human Erythropoietin Against Cisplatin-Induced Oxidative Stress and Nephrotoxicity in Rat Kidney

(2011) Karima Rjiba-Touati et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Perioperative Chemotherapy Compared With Surgery Alone for Resectable Gastroesophageal Adenocarcinoma: An FNCLCC and FFCD Multicenter Phase III Trial

(2011) Marc Ychou et al.   JOURNAL OF CLINICAL ONCOLOGY

Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumour activity

(2011) P. D. Sanchez-Gonzalez et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Necrotic Concentrations of Cisplatin Activate the Apoptotic Machinery but Inhibit Effector Caspases and Interfere with the Execution of Apoptosis

(2011) Sandra M. Sancho-Martínez et al.   TOXICOLOGICAL SCIENCES

Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy

(2011) Amteshwar Singh Jaggi et al.   TOXICOLOGY

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

(2011) Paolo E. Porporato et al.   Frontiers in Pharmacology

Effects of a novel cystine-based glutathione precursor on oxidative stress in vascular smooth muscle cells

(2010) Indrani Sinha-Hikim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Protecting Cisplatin-Induced Nephrotoxicity with Cimetidine Does Not Affect Antitumor Activity

(2010) Hiromu Katsuda et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Early reduction of glucose uptake after cisplatin treatment is a marker of cisplatin sensitivity in ovarian cancer

(2010) Tomomi Egawa-Takata et al.   CANCER SCIENCE

Hexokinase II detachment from the mitochondria potentiates cisplatin induced cytotoxicity through a caspase-2 dependent mechanism

(2010) Nataly Shulga et al.   CELL CYCLE

The Role of Oxidative Stress and Anti-Oxidant Treatment in Platinum-Induced Peripheral Neurotoxicity

(2010) V. A. Carozzi et al.   CURRENT CANCER DRUG TARGETS

Glucose metabolism in cancer cells

(2010) Alessandro Annibaldi et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Comparative Effects of Alpha Lipoic Acid and Melatonin on Cisplatin-Induced Neurotoxicity

(2010) Seckin Tuncer et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Inhibition of Axonal Transport Caused by tert-Butyl Hydroperoxide in Cultured Mouse Dorsal Root Ganglion Neurons

(2010) Risa Isonaka et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Vitamin E neuroprotection for cisplatin neuropathy: A randomized, placebo-controlled trial

(2010) A. Pace et al.   NEUROLOGY

How many cisplatin administration protocols does your department use?

(2009) A.P. GREYSTOKE et al.   EUROPEAN JOURNAL OF CANCER CARE

Co-supplementation of single and multi doses of vitamins C and E ameliorates cisplatin-induced acute renal failure in mice

(2009) T.A. Ajith et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Cisplatin interaction with phosphatidylserine bilayer studied by solid-state NMR spectroscopy

(2009) Magnus Jensen et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Is Glutathione the Major Cellular Target of Cisplatin? A Study of the Interactions of Cisplatin with Cancer Cell Extracts

(2009) Yonit Kasherman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

The Warburg Effect: Why and How Do Cancer Cells Activate Glycolysis in the Presence of Oxygen?

(2008) Miguel Lopez-Lazaro   Anti-Cancer Agents in Medicinal Chemistry

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

(2008) E D Michelakis et al.   BRITISH JOURNAL OF CANCER

Cisplatin Cytotoxicity: DNA and Plasma Membrane Targets

(2008) Amelie Rebillard et al.   CURRENT MEDICINAL CHEMISTRY

Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity

(2008) Yolanda I. Chirino et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy

(2008) Giorgia Melli et al.   EXPERIMENTAL NEUROLOGY

Dichloroacetate induces apoptosis in endometrial cancer cells

(2008) Jason Y.Y. Wong et al.   GYNECOLOGIC ONCOLOGY

Cisplatin primes murine peritoneal macrophages for enhanced expression of nitric oxide, proinflammatory cytokines, TLRs, transcription factors and activation of MAP kinases upon co-incubation with L929 cells

(2008) Puja Chauhan et al.   IMMUNOBIOLOGY

Regulation and Pathological Role of p53 in Cisplatin Nephrotoxicity

(2008) M. Jiang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

(2008) N. Pabla et al.   KIDNEY INTERNATIONAL

SIRT1 Contributes in Part to Cisplatin Resistance in Cancer Cells by Altering Mitochondrial Metabolism

(2008) X.-J. Liang et al.   MOLECULAR CANCER RESEARCH

3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs

(2008) Linda Strandberg Ihrlund et al.   Molecular Oncology

Protective Effects of Vitamin C on Cisplatin-Induced Renal Damage: A Light and Electron Microscopic Study

(2008) Yeter Topcu Tarladacalisir et al.   RENAL FAILURE

Cisplatin nephrotoxicity is mediated by gamma glutamyltranspeptidase, not via a C-S lyase governed biotransformation pathway

(2008) Richard D. Wainford et al.   TOXICOLOGY

Cisplatin upregulates mitochondrial nitric oxide synthase and peroxynitrite formation to promote renal injury

(2008) Michaela Jung et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cisplatin induces mitochondrial oxidative stress with resultant energetic metabolism impairment, membrane rigidification and apoptosis in rat liver

(2007) N. M. Martins et al.   JOURNAL OF APPLIED TOXICOLOGY

Antiemetics: an update and the MASCC guidelines applied in clinical practice

(2007) Jørn Herrstedt   Nature clinical practice. Oncology