Article
Medicine, General & Internal
Jun Watanabe, Kazuhiko Kotani, Alejandro Gugliucci
Summary: This study conducted a meta-analysis on the relationship between oxidative stress and paraoxonase 1 (PON1) in chronic kidney disease (CKD). The results showed that CKD patients had lower PON1 activity compared to healthy controls. Further studies are needed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Alfredo G. Casanova, Francisco J. Lopez-Hernandez, Laura Vicente-Vicente, Ana Morales
Summary: Antioxidant therapy appears to reduce the progression of chronic kidney disease, with pentoxifylline and bardoxolone methyl showing the most robust protection. However, individual variability and potential off-target effects introduce uncertainty regarding the role of oxidative stress in CKD progression and the effectiveness of antioxidant therapy. Personalized antioxidant therapy based on individual factors is necessary for optimal treatment outcomes.
Article
Biochemistry & Molecular Biology
Jorge Andrade-Sierra, Leonardo Pazarin-Villasenor, Francisco Gerardo Yanowsky-Escatell, Elodia Nataly Diaz-de la Cruz, Andres Garcia-Sanchez, Ernesto German Cardona-Munoz, Francisco Javier Munguia-Galaviz, Alejandra de Alba-Razo, Alejandra Guillermina Miranda-Diaz
Summary: Early diagnosis of Chronic Kidney Disease (CKD) is crucial in reducing complications. This study found that patients with type 2 diabetes mellitus (T2DM) had higher levels of oxidative and inflammatory markers during CKD progression, while CKD stage progression in patients without T2DM was associated with antioxidant and inflammatory marker outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Medicine, General & Internal
Brendon G. Neuen, Robert Fletcher, Hiddo J. L. Heerspink
Summary: The editorial suggests that the benefit of empagliflozin in slowing the progression of chronic kidney disease is less evident among patients who do not receive RAS blockade. This is because this subgroup only accounts for 15% of the overall trial population, resulting in less precise effect estimates and wider confidence intervals.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ashish Verma, Anand Vaidya, Sonu Subudhi, Sushrut S. Waikar
Summary: The study found that higher serum aldosterone levels are independently associated with an increased risk for kidney disease progression in individuals with chronic kidney disease, regardless of concomitant diabetes. This suggests a potential role for mineralocorticoid receptor antagonists in delaying CKD progression even in those without diabetes.
EUROPEAN HEART JOURNAL
(2022)
Review
Urology & Nephrology
Sagar Verma, Priyanka Singh, Shiffali Khurana, Nirmal Kumar Ganguly, Ritushree Kukreti, Luciano Saso, Devinder Singh Rana, Vibha Taneja, Vinant Bhargava
Summary: Moderate levels of endogenous reactive oxygen species (ROS) are important for cellular activities, but high levels can lead to toxicity and various diseases. Oxidative stress is a major factor in renal function deterioration, and therapies targeting oxidative stress are being explored for chronic kidney disease (CKD patients. Factors such as upregulation of genes related to ROS generation, chronic inflammation, and compromised antioxidant defense contribute to progressive renal function loss. Treatments like xanthine oxidase inhibitors and dietary antioxidants are gaining interest for CKD patients.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2021)
Review
Medicine, General & Internal
Kamyar Kalantar-Zadeh, Tazeen H. Jafar, Dorothea Nitsch, Brendon L. Neuen, Vlado Perkovic
Summary: Chronic kidney disease is a progressive disease with no cure, and preserving kidney function through lifestyle adjustments and pharmacological interventions can improve outcomes. A plant-dominant, low-protein, and low-salt diet may help mitigate glomerular hyperfiltration and preserve renal function. Various pharmacotherapies can also be used to alter intrarenal haemodynamics and protect the kidney from further damage.
Review
Chemistry, Multidisciplinary
Solmaz Maleki Dizaj, Aziz Eftekhari, Shakar Mammadova, Elham Ahmadian, Mohammadreza Ardalan, Soodabeh Davaran, Aygun Nasibova, Rovshan Khalilov, Mahbuba Valiyeva, Sevil Mehraliyeva, Ebrahim Mostafavi
Summary: This review focuses on current research and clinical applications of nanoparticles in the diagnosis of chronic kidney disease (CKD) and other renal diseases that may lead to CKD.
APPLIED SCIENCES-BASEL
(2021)
Review
Pharmacology & Pharmacy
R. Supriyadi, M. I. A. Koswara, M. A. Soelaeman, I. Huang
Summary: This systematic review and meta-analysis aimed to investigate the effect of antioxidant supplementation on oxidative stress and proinflammatory biomarkers in patients with Chronic Kidney Disease (CKD). The analysis included 32 published studies, and the results showed that curcumin/turmeric and vitamin E supplementation effectively reduced serum CRP levels in CKD patients. However, there is still inconclusive evidence and conflicting results for other antioxidants, indicating a need for further high-quality randomized controlled trials.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Huan-Da Chen, Chih-Chuan Yu, I-Hsiao Yang, Chi-Chih Hung, Mei-Chuan Kuo, Der-Cherng Tarng, Jer-Ming Chang, Daw-Yang Hwang
Summary: This study reveals the significance of ADTKD-UMOD as a cause of chronic kidney disease in the Taiwanese population, identifying two previously unreported UMOD missense variants.
Review
Biochemistry & Molecular Biology
Silvio Borrelli, Ida Matarazzo, Eugenio Lembo, Laura Peccarino, Claudia Annoiato, Maria Rosaria Scognamiglio, Andrea Foderini, Chiara Ruotolo, Aldo Franculli, Federica Capozzi, Pavlo Yavorskiy, Fatme Merheb, Michele Provenzano, Gaetano La Manna, Luca De Nicola, Roberto Minutolo, Carlo Garofalo
Summary: Increasing potassium intake can improve blood pressure and cardiovascular outcomes, but hyperkalaemia is prevalent in CKD patients and associated with poor prognosis. The correct nutritional approach to hyperkalaemia is still controversial, but new K+-binder drugs offer a safe and effective option for controlling serum potassium levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Satyesh K. Sinha, Michael Mellody, Maria Beatriz Carpio, Robert Damoiseaux, Susanne B. Nicholas
Summary: Osteopontin (OPN) is a protein with various physiological functions and has been implicated in the pathogenesis of chronic kidney disease (CKD). OPN may serve as a biomarker in CKD and targeting OPN could be a potential treatment strategy.
Review
Cardiac & Cardiovascular Systems
Ashton C. Lai, Solomon W. Bienstock, Raman Sharma, Karl Skorecki, Frans Beerkens, Rajeev Samtani, Andrew Coyle, Tonia Kim, Usman Baber, Anton Camaj, David Power, Valentin Fuster, Martin E. Goldman
Summary: Cardiovascular disease is the leading cause of death in end-stage renal disease patients, exacerbated by dialysis treatment. Multimodality imaging may offer additional prognostication and risk stratification for these patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Urology & Nephrology
Johannes Ruhe, Jennifer Nadal, Barbara Barthlein, Heike Meiselbach, Ulla T. Schultheiss, Fruzsina Kotsis, Helena Stockmann, Vera Krane, Claudia Sommerer, Ivonne Loeffler, Turgay Saritas, Jan T. Kielstein, Thomas Sitter, Markus P. Schneider, Matthias Schmid, Christoph Wanner, Kai-Uwe Eckardt, Gunter Wolf, Martin Busch
Summary: Diabetes mellitus (DM) and chronic kidney disease (CKD) are known risk factors for cardiovascular disease and mortality. This study found that DM significantly increased the risk of cardiovascular and non-cardiovascular death, major adverse cardiovascular events, and hospitalization for heart failure in patients with moderate to severe CKD. The increased risk was similar in patients with CKD caused by cardiovascular/metabolic diseases and those with genuine CKD. Patients with DM and CKD caused by cardiovascular/metabolic diseases were particularly susceptible to heart failure.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Medicine, General & Internal
Lemei Hu, Quanjun Liu, Yunyao Ou, Dongdong Li, Yongdong Wu, Hengyi Li, Zhigang Zhu, Ming Liang
Summary: This study aimed to determine the relationship between dietary antioxidant intake and vascular calcification (VC), especially in the population with chronic kidney disease (CKD). The results showed that dietary lycopene was negatively associated with severe arterial calcification, but dietary antioxidants were not significantly associated with VC in CKD patients.
ANNALS OF MEDICINE
(2023)