The role of arginine and the modified arginine deiminase enzyme ADI-PEG 20 in cancer therapy with special emphasis on Phase I/II clinical trials

Targeting Arginine-Dependent Cancers with Arginine-Degrading Enzymes: Opportunities and Challenges

(2014) Melissa M. Phillips et al.   Cancer Research and Treatment

Metabolic Response to Pegylated Arginine Deiminase in Mesothelioma With Promoter Methylation of Argininosuccinate Synthetase

(2013) Peter W. Szlosarek et al.   JOURNAL OF CLINICAL ONCOLOGY

Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase

(2012) L G Feun et al.   BRITISH JOURNAL OF CANCER

A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma

(2012) Thomas Yau et al.   INVESTIGATIONAL NEW DRUGS

Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma

(2012) Patrick A. Ott et al.   INVESTIGATIONAL NEW DRUGS

From cancer metabolism to new biomarkers and drug targets

(2011) F. Chiaradonna et al.   BIOTECHNOLOGY ADVANCES

Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase

(2011) M P Kelly et al.   BRITISH JOURNAL OF CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Neutrophil Degranulation and Immunosuppression in Patients with GBM: Restoration of Cellular Immune Function by Targeting Arginase I

(2011) T. R. Sippel et al.   CLINICAL CANCER RESEARCH

N-α-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-l-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis

(2011) Van C. Willis et al.   JOURNAL OF IMMUNOLOGY

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients

(2010) T-S Yang et al.   BRITISH JOURNAL OF CANCER

Directed Evolution of an Antitumor Drug (Arginine Deiminase PpADI) for Increased Activity at Physiological pH

(2010) Leilei Zhu  et al.   CHEMBIOCHEM

Phase II Study of Pegylated Arginine Deiminase for Nonresectable and Metastatic Hepatocellular Carcinoma

(2010) Evan S. Glazer et al.   JOURNAL OF CLINICAL ONCOLOGY

Amino acids: metabolism, functions, and nutrition

(2009) Guoyao Wu   AMINO ACIDS

Arginine Deiminase as a Novel Therapy for Prostate Cancer Induces Autophagy and Caspase-Independent Apoptosis

(2009) R. H. Kim et al.   CANCER RESEARCH

Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes

(2009) Paulo C. Rodriguez et al.   CANCER RESEARCH

Metabolic transformation in cancer

(2009) D. A. Tennant et al.   CARCINOGENESIS

Glucose metabolism and programmed cell death: an evolutionary and mechanistic perspective

(2009) Ayala King et al.   CURRENT OPINION IN CELL BIOLOGY

Potential for amino acids supplementation during inflammatory bowel diseases

(2009) Moïse Coëffier et al.   INFLAMMATORY BOWEL DISEASES

Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1 /Sp4

(2009) W.-B. Tsai et al.   MOLECULAR CANCER THERAPEUTICS

Anti-Aging Therapy With Human Growth Hormone Associated With Metastatic Colon Cancer in a Patient With Crohn’s Colitis

(2008) Gil Y. Melmed et al.   Clinical Gastroenterology and Hepatology

Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction

(2008) Pascal Crenn et al.   CLINICAL NUTRITION

Inhibition of gastric cancer cell growth by arginine: Molecular mechanisms of action

(2008) Shayanthan Nanthakumaran et al.   CLINICAL NUTRITION

Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase

(2008) Tawnya L. Bowles et al.   INTERNATIONAL JOURNAL OF CANCER

Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination

(2008) Brian A Kidd et al.   ARTHRITIS RESEARCH & THERAPY