Fasudil and its analogs: a new powerful weapon in the long war against central nervous system disorders?

Increased Dendrite Branching in AβPP/PS1 Mice and Elongation of Dendrite Arbors by Fasudil Administration

(2017) Brian A. Couch et al.   JOURNAL OF ALZHEIMERS DISEASE

The therapeutic effects of Rho-ROCK inhibitors on CNS disorders

(2016) Takekazu Kubo   Therapeutics and Clinical Risk Management

Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells

(2013) Noriaki Satoh et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Protein Kinase G-I Deficiency Induces Pulmonary Hypertension through Rho A/Rho Kinase Activation

(2012) Yidan D. Zhao et al.   AMERICAN JOURNAL OF PATHOLOGY

Rho-kinase inhibition improves vasodilator responsiveness during hyperinsulinemia in the metabolic syndrome

(2012) Francesca Schinzari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Conjugates of 5-isoquinolinesulfonylamides and oligo-d-arginine possess high affinity and selectivity towards Rho kinase (ROCK)

(2012) Darja Lavogina et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease

(2012) L. Tonges et al.   BRAIN

Distinct Distribution and Localization of Rho-kinase in Mouse Epithelial, Muscle and Neural Tissues

(2012) Michiro Iizuka et al.   CELL STRUCTURE AND FUNCTION

Fasudil Ameliorates Disease Progression in Experimental Autoimmune Encephalomyelitis, Acting Possibly Through Antiinflammatory Effect

(2012) Shao-Wei Hou et al.   CNS Neuroscience & Therapeutics

Multifunctional Ligands in Medicinal Inorganic Chemistry- Current Trends and Future Directions

(2012) Linus Chiang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Neuroproteomics approach and neurosystems biology analysis: ROCK inhibitors as promising therapeutic targets in neurodegeneration and neurotrauma

(2012) Mohamad Raad et al.   ELECTROPHORESIS

Fasudil improves the endothelial dysfunction in the aorta of spontaneously hypertensive rats

(2012) Panagiota Tsounapi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Retinal arteriolar responses to acute severe elevation in systemic blood pressure in cats: Role of endothelium-derived factors

(2012) Seigo Nakabayashi et al.   EXPERIMENTAL EYE RESEARCH

Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders

(2012) Werner J Geldenhuys et al.   Expert Opinion on Drug Discovery

Xavier Montalban: a pioneer in understanding multiple sclerosis

(2012) Zuberoa Marcos   LANCET NEUROLOGY

Involvement of microglial RhoA/Rho-Kinase pathway activation in the dopaminergic neuron death. Role of angiotensin via angiotensin type 1 receptors

(2012) Begoña Villar-Cheda et al.   NEUROBIOLOGY OF DISEASE

A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator

(2012) M. Ishiguro et al.   NEUROSCIENCE

Inhibition of Rho-kinase attenuates endothelial–leukocyte interaction during ischemia–reperfusion injury

(2012) Qing Mei Wang et al.   VASCULAR MEDICINE

Impact of Behavioral Control on the Processing of Nociceptive Stimulation

(2012) James W. Grau et al.   Frontiers in Physiology

Rho-kinase: important new therapeutic target in cardiovascular diseases

(2011) Kimio Satoh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Current therapies in ischemic stroke. Part A. Recent developments in acute stroke treatment and in stroke prevention

(2011) Erasmia Broussalis et al.   DRUG DISCOVERY TODAY

Cardioprotective Effect of a Combination of Rho-Kinase Inhibitor and P38 MAPK Inhibitor on Cardiovascular Remodeling and Oxidative Stress in Dahl Rats

(2011) Hiroshi Takeshima et al.   Journal of Atherosclerosis and Thrombosis

Antivasospastic Effects of Hydroxyfasudil, a Rho-Kinase Inhibitor, After Subarachnoid Hemorrhage

(2011) Shin-ichi Satoh et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Fasudil and Ozagrel in Combination Show Neuroprotective Effects on Cerebral Infarction after Murine Middle Cerebral Artery Occlusion

(2011) A. Koumura et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Priorities in Parkinson's disease research

(2011) Wassilios G. Meissner et al.   NATURE REVIEWS DRUG DISCOVERY

Efficacy and Safety of Fasudil in Patients With Subarachnoid Hemorrhage: Final Results of a Randomized Trial of Fasudil Versus Nimodipine

(2011) Jizong ZHAO et al.   NEUROLOGIA MEDICO-CHIRURGICA

Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride

(2011) Y. Hou et al.   NEUROSCIENCE

Why Do We Need Multifunctional Neuroprotective and Neurorestorative Drugs for Parkinson's and Alzheimer's Diseases as Disease Modifying Agents

(2011) Moussa B. H. Youdim   Experimental Neurobiology

Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors

(2010) Peter Ray et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: Synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator

(2010) Paul A. Lapchak et al.   BRAIN RESEARCH

Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases

(2010) Ming Dong et al.   DRUG DISCOVERY TODAY

Beneficial effects of a combination of Rho-kinase inhibitor and ACE inhibitor on tubulointerstitial fibrosis induced by unilateral ureteral obstruction

(2010) Yosuke Takeda et al.   HYPERTENSION RESEARCH

Characterization of Fasudil in Preclinical Models of Pain

(2010) Janel M. Boyce-Rustay et al.   JOURNAL OF PAIN

Protective effects of cold spinoplegia with fasudil against ischemic spinal cord injury in rabbits

(2010) Hironori Baba et al.   JOURNAL OF VASCULAR SURGERY

Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF

(2009) Jing Ding et al.   BRAIN BEHAVIOR AND IMMUNITY

Rho-kinase inhibitors Y-27632 and fasudil prevent agonist-induced vasospasm in human radial artery

(2009) Olcay Murat Disli et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity

(2009) C. Hahmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rho Kinase (ROCK) Inhibitors and Their Application to Inflammatory Disorders

(2009) Philip LoGrasso et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Simultaneous quantitative analysis of fasudil and its active metabolite in human plasma by liquid chromatography electro-spray tandem mass spectrometry

(2009) Huaying Chen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, Fasudil on axon regeneration in rat spinal cord injury

(2009) Yasuhiro Chiba et al.   NEUROPATHOLOGY

Intratrigeminal ganglionic injection of LPA causes neuropathic pain-like behavior and demyelination in rats

(2009) Dong K. Ahn et al.   PAIN

Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin

(2008) Marjan Boerma et al.   BLOOD COAGULATION & FIBRINOLYSIS

Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice

(2008) S Y İnan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Applications for ROCK kinase inhibition

(2008) Michael F Olson   CURRENT OPINION IN CELL BIOLOGY

Safety and Efficacy of Fasudil Monotherapy and Fasudil-Ozagrel Combination Therapy in Patients With Subarachnoid Hemorrhage: Sub-analysis of the Post-marketing Surveillance Study

(2008) Yoshio SUZUKI et al.   NEUROLOGIA MEDICO-CHIRURGICA