Article
Chemistry, Multidisciplinary
Lei Fan, Can Liu, Xiuxing Chen, Lei Zheng, Yan Zou, Huiquan Wen, Pengfei Guan, Fang Lu, Yian Luo, Guoxin Tan, Peng Yu, Dafu Chen, Chunlin Deng, Yongjian Sun, Lei Zhou, Chengyun Ning
Summary: Neural tissue-like electroconductive hydrogels loaded with BMSC-exosomes have been developed for the treatment of spinal cord injury, and they show enhanced neural regeneration, reduced inflammation, and improved functional recovery.
Article
Pharmacology & Pharmacy
Qinghai Zhu, Yuting Tang, Tian Zhou, Li Yang, Gao Zhang, Ying Meng, Huixin Zhang, Jun Gao, Chenxing Wang, Yu-Xiong Su, Jinhai Ye
Summary: This study found that exosomes derived from pre-differentiated AB-BMSCs carrying specific miRNAs have a positive effect on bone regeneration. The 7-day pre-differentiation of exosomes effectively promoted BMSCs differentiation and activated the PI3K/Akt signaling pathway through differential expression of miRNAs. Gene modification of exosomes provides great potential as a bone regeneration strategy.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Materials Science, Biomaterials
Ziyan Wang, Feixue Mi, Jinchen Li, Dandan Chen, Minmin Lin, Xinyu Wang, Siying Wu, Changfeng Wu, Chao Liu
Summary: Bone marrow stromal cells (BMSCs) have great potential in bone defect repair. By using semiconducting polymer dots (Pdots) as markers, we successfully selected BMSCs and evaluated their therapeutic efficacy in a bone defect model.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Endocrinology & Metabolism
Viktorija Avilkina, Damien Leterme, Guillaume Falgayrac, Jerome Delattre, Flore Miellot, Veronique Gauthier, Christophe Chauveau, Olfa Ghali Mhenni
Summary: This study demonstrates, for the first time, that the duration and severity of energy deficits are critical for changes in bone parameters, BMSC differentiation, and Sirt1 expression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Lite Ge, Jing Zhao, Huiyin Deng, Chunli Chen, Zhiping Hu, Liuwang Zeng
Summary: This meta-analysis study found that naive MSC(M) therapy can decrease mortality in rodent models of sepsis. However, there is significant heterogeneity among the studies and several knowledge gaps, including the lack of large animal studies and uncertainty regarding the optimal dose of MSC(M) transplantation in sepsis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Changyu Li, Jianan Song, Yanping Wang, Yu Shi, Jiayu Ji, Qian Lin, Yumei Liu
Summary: The results show that ASCS can improve cell adhesion and proliferation, suggesting the potential of ASCS-BMSC combination for treating spinal cord injury.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Huitao Liu, Jingling Zhang, Xingxing Xu, Sheng Lu, Danlu Yang, Changnan Xie, Mengxian Jia, Wenbin Zhang, Lingting Jin, Xiwu Wang, Xiya Shen, Fayi Li, Wangfei Wang, Xiaomei Bao, Sijia Li, Minyu Zhu, Wei Wang, Ying Wang, Zhihui Huang, Honglin Teng
Summary: The study identified that upregulation of SARM1 in neurons and astrocytes at early stage after SCI. Conditional deletion of SARM1 in neurons and astrocytes promoted functional recovery and neuronal regeneration after SCI, while reducing neuroinflammation.
Review
Biotechnology & Applied Microbiology
Xuanxuan Zhang, Wenwei Jiang, Yan Lu, Tiantian Mao, Yu Gu, Dingyue Ju, Chuanming Dong
Summary: Spinal cord injury (SCI) is a serious and disabling disease that often leads to sensory and motor dysfunction, accompanied by various secondary outcomes. The main treatments for SCI include surgery, drugs, and rehabilitation. Cell therapy and exosomes have shown promise in treating SCI, but the therapeutic effect is still controversial. Combining biomaterial scaffolds and exosomes can enhance their delivery to the injury site and improve their viability.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Cell Biology
Serena Silvestro, Emanuela Mazzon
Summary: Spinal cord injury is a devastating injury to the central nervous system, and current therapies have not been successful. MiRNA plays a crucial role in CNS development and pathological processes after neural injury, making it a promising candidate for SCI therapy.
Article
Multidisciplinary Sciences
Cheng Su, Xiao Zheng, Yanjin He, Li Long, Wenchuan Chen
Summary: This study identified aberrant expression of circRNAs in hUCMSCs during osteogenic differentiation, constructed competing endogenous RNA networks using bioinformatics tools, elucidated underlying mechanisms, and validated the osteogenic-promoting effect of a specific circRNA.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Zhenxin Hu, Lina Xuan, Tingting Wu, Nizhou Jiang, Xiangjun Liu, Jiazhen Chang, Te Wang, Nan Han, Xiliang Tian
Summary: Taxifolin reduces neuroinflammation and microglial pyroptosis after spinal cord injury by inhibiting oxidative stress and regulating the PI3K/AKT signaling pathway. It also promotes axonal regeneration and improves functional recovery. Taxifolin may be a potential therapeutic agent for spinal cord injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ya-Li Zhang, Liang Liu, Yaser Peymanfar, Paul Anderson, Cory J. Xian
Summary: The differentiation switch of BMSCs can lead to changes in bone/fat formation in the bone marrow, causing bone growth defects and disordered bone metabolism. MicroRNAs may play a significant role in regulating this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Zawadzka, Marine Yeghiazaryan, Sylwia Niedziolka, Krzysztof Miazga, Anna Kwasniewska, Marek Bekisz, Urszula Slawinska
Summary: Enhanced remyelination plays an important role in the recovery of motor and sensory functions in spinal cord injuries. The injection of ethidium bromide induced multifocal demyelination, leading to increased oligodendrocyte progenitor cells after 14 days. In double-EB-injected rats, most axons were remyelinated by Schwann cells and went beyond the injury epicenter into distant spinal cord segments, while some serotoninergic fibers grew caudally through the injury site. Behavioral tests confirmed significant improvement in locomotor function recovery, which was impaired by the blockade of serotonin receptors, emphasizing the important role of restored serotonergic fibers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Gong Ho Han, Seong Jun Kim, Wan-Kyu Ko, Daye Lee, In-Bo Han, Seung Hun Sheen, Je Beom Hong, Seil Sohn
Summary: In this study, transplantation of TUDCA-induced M2 macrophages was found to promote anti-neuroinflammatory effects and motor function recovery in a spinal cord injury model, indicating a potential alternative cell therapy for SCI.
CELL PROLIFERATION
(2021)
Article
Cell Biology
Junhao Deng, Miao Li, Fanqi Meng, Zhongyang Liu, Song Wang, Yuan Zhang, Ming Li, Zhirui Li, Licheng Zhang, Peifu Tang
Summary: This study demonstrated that MSCs cultured in three-dimensional spheroids showed enhanced secretion of anti-inflammatory and trophic factors, leading to improved therapeutic effects in treating spinal cord injury.
CELL DEATH & DISEASE
(2021)