Insulin sensitizers in 2013: new insights for the development of novel therapeutic agents to treat metabolic diseases

Clinical Proof-of-Concept Study With MSDC-0160, a Prototype mTOT-Modulating Insulin Sensitizer

(2013) J R Colca et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets

(2013) Nidhi Rohatgi et al.   PLoS One

Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins

(2013) Jerry R. Colca et al.   PLoS One

Comparative Molecular Profiling of the PPARα/γ Activator Aleglitazar: PPAR Selectivity, Activity and Interaction with Cofactors

(2012) Michel Dietz et al.   ChemMedChem

Insulin Resistance and Metabolic Derangements in Obese Mice Are Ameliorated by a Novel Peroxisome Proliferator-activated Receptor γ-sparing Thiazolidinedione

(2012) Zhouji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Peroxisome Proliferator-Activated Receptors (PPARs): Development of Modulators

(2012) Céline Pirat et al.   JOURNAL OF MEDICINAL CHEMISTRY

Redox Regulation of Mitochondrial Function

(2011) Diane E. Handy et al.   ANTIOXIDANTS & REDOX SIGNALING

Comparison of Cardiovascular Outcomes in Elderly Patients With Diabetes Who Initiated Rosiglitazone vs Pioglitazone Therapy

(2008) Wolfgang C. Winkelmayer et al.   ARCHIVES OF INTERNAL MEDICINE

A New Mechanism Involving ERK Contributes to Rosiglitazone Inhibition of Tumor Necrosis Factor-α and Interferon-γ Inflammatory Effects in Human Endothelial Cells

(2008) Adriana Lombardi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Synthesis and Biological Evaluation of (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acids: A Novel Series of PPARγ Agonists

(2008) Satoru Azukizawa et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Rosiglitazone Stimulates Nitric Oxide Synthesis in Human Aortic Endothelial Cells via AMP-activated Protein Kinase

(2008) James G. Boyle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY