Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets

Clinical Proof-of-Concept Study With MSDC-0160, a Prototype mTOT-Modulating Insulin Sensitizer

(2013) J R Colca et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins

(2013) Jerry R. Colca et al.   PLoS One

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Insulin Resistance and Metabolic Derangements in Obese Mice Are Ameliorated by a Novel Peroxisome Proliferator-activated Receptor γ-sparing Thiazolidinedione

(2012) Zhouji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mitochondrial Mystery, Solved

(2012) A. S. Divakaruni et al.   SCIENCE

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

(2012) D. K. Bricker et al.   SCIENCE

Potential role of insulin signaling on vascular smooth muscle cell migration, proliferation, and inflammation pathways

(2011) Eugenio Cersosimo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Evidence of Endoplasmic Reticulum Stress Mediating Cell Death in Transplanted Human Islets

(2011) Sarita Negi et al.   CELL TRANSPLANTATION

Chronic Effects of Palmitate Overload on Nutrient-Induced Insulin Secretion and Autocrine Signalling in Pancreatic MIN6 Beta Cells

(2011) Maria L. Watson et al.   PLoS One

Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes

(2011) M Szabat et al.   Cell Death & Disease

Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Improves  -Cell Function Under Stress

(2010) D. Gurevitch et al.   DIABETES

Metformin Activates AMP Kinase through Inhibition of AMP Deaminase

(2010) Jiangyong Ouyang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARγ: a circadian transcription factor in adipogenesis and osteogenesis

(2010) Masanobu Kawai et al.   Nature Reviews Endocrinology

Cross-Talk between PPARγand Insulin Signaling and Modulation of Insulin Sensitivity

(2010) Anna Leonardini et al.   PPAR Research

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

Thiazolidinediones in prediabetes and early type 2 diabetes: What can be learned about that disease’s pathogenesis

(2009) Jack L. Leahy   Current Diabetes Reports

β-Cells at the crossroads: choosing between insulin granule production and proliferation

(2009) Yanmei Liu et al.   DIABETES OBESITY & METABOLISM

Smad3-dependent and -independent pathways are involved in peritoneal membrane injury

(2009) Pranali Patel et al.   KIDNEY INTERNATIONAL

Effects of a PPAR-gamma agonist, on growth factor and insulin stimulated endothelial cells

(2009) Cyrus V. Desouza et al.   VASCULAR PHARMACOLOGY

HES-1 Is Involved in Adaptation of Adult Human  -Cells to Proliferation In Vitro

(2008) Y. Bar et al.   DIABETES

Glycogen Synthase Kinase-3 and Mammalian Target of Rapamycin Pathways Contribute to DNA Synthesis, Cell Cycle Progression, and Proliferation in Human Islets

(2008) H. Liu et al.   DIABETES

Maturation of Adult β-Cells Revealed Using aPdx1/InsulinDual-Reporter Lentivirus

(2008) Marta Szabat et al.   ENDOCRINOLOGY

Cellular origins of adult human islet in vitro dedifferentiation

(2008) Stephen C Hanley et al.   LABORATORY INVESTIGATION