Current status of renin–aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease

Antihypertensive Therapy and Cerebral Hemodynamics in Executive Mild Cognitive Impairment: Results of a Pilot Randomized Clinical Trial

(2013) Ihab Hajjar et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Moving towards early clinical trials for amyloid-targeted therapy in Alzheimer's disease

(2013) Paul S. Aisen et al.   NATURE REVIEWS DRUG DISCOVERY

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Pathology and pathogenesis of vascular cognitive impairment—a critical update

(2013) Kurt A. Jellinger   Frontiers in Aging Neuroscience

Risk Factors for β-Amyloid Deposition in Healthy Aging

(2013) Karen M. Rodrigue et al.   JAMA Neurology

Effect of Antihypertensive Therapy on Cognitive Function in Early Executive Cognitive Impairment: A Double-blind Randomized Clinical Trial

(2012) Ihab Hajjar et al.   ARCHIVES OF INTERNAL MEDICINE

Impact of Angiotensin Receptor Blockers on Alzheimer Disease Neuropathology in a Large Brain Autopsy Series

(2012) Ihab Hajjar et al.   ARCHIVES OF NEUROLOGY

Acetylcholinesterase inhibitors: a patent review (2008 – present)

(2012) Miroslav Pohanka   EXPERT OPINION ON THERAPEUTIC PATENTS

Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains

(2012) Minjie Tian et al.   FEBS LETTERS

Blood Pressure Trajectories From Midlife to Late Life in Relation to Dementia in Women Followed for 37 Years

(2012) Erik Joas et al.   HYPERTENSION

Alzheimer’s drugs take a new tack

(2012) Ewen Callaway   NATURE

Drug repositioning for Alzheimer's disease

(2012) Anne Corbett et al.   NATURE REVIEWS DRUG DISCOVERY

Renin inhibitor aliskiren exerts neuroprotection against amyloid beta-peptide toxicity in rat cortical neurons

(2012) Shang-Der Chen et al.   NEUROCHEMISTRY INTERNATIONAL

Roles of Brain Angiotensin II in Cognitive Function and Dementia

(2012) Masaki Mogi et al.   International Journal of Hypertension

Angiotensin-converting enzyme inhibitors and incidence of mild cognitive impairment. The Italian Longitudinal Study on Aging

(2011) Vincenzo Solfrizzi et al.   AGE

Antihypertensive Therapy Is Associated with Reduced Rate of Conversion to Alzheimer's Disease in Midregional Proatrial Natriuretic Peptide Stratified Subjects with Mild Cognitive Impairment

(2011) Philine Schneider et al.   BIOLOGICAL PSYCHIATRY

The Association Between Blood Pressure and Incident Alzheimer Disease

(2011) Melinda C. Power et al.   EPIDEMIOLOGY

Distinguishing Alzheimer’s disease from other major forms of dementia

(2011) Stella Karantzoulis et al.   Expert Review of Neurotherapeutics

Attenuation of Brain Damage and Cognitive Impairment by Direct Renin Inhibition in Mice With Chronic Cerebral Hypoperfusion

(2011) Yi-Fei Dong et al.   HYPERTENSION

Angiotensin II Binding to Angiotensin I–Converting Enzyme Triggers Calcium Signaling

(2011) Paola B. Guimarães et al.   HYPERTENSION

Direct Stimulation of Angiotensin II Type 2 Receptor Enhances Spatial Memory

(2011) Fei Jing et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Aβ-Degrading Enzymes: Potential for Treatment of Alzheimer Disease

(2011) James Scott Miners et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Central Angiotensin II Stimulation Promotes β Amyloid Production in Sprague Dawley Rats

(2011) Donglin Zhu et al.   PLoS One

Identification and characterization of a functional mitochondrial angiotensin system

(2011) P. M. Abadir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain renin-angiotensin—A new look at an old system

(2011) John W. Wright et al.   PROGRESS IN NEUROBIOLOGY

Strain differences in the effects of Angiotensin IV on mouse cognition

(2010) Bruno J.D. Golding et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glycogen synthase kinase-3β negatively regulates TGF-β1 and Angiotensin II-mediated cellular activity through interaction with Smad3

(2010) Fang Hua et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Placebo-Controlled Trials of Blood Pressure–Lowering Therapies for Primary Prevention of Dementia

(2010) Jan A. Staessen et al.   HYPERTENSION

Angiotensin II sustains brain inflammation in mice via TGF-β

(2010) Tobias V. Lanz et al.   JOURNAL OF CLINICAL INVESTIGATION

Toward a pathological definition of vascular dementia

(2010) Lea Tenenholz Grinberg et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies

(2010) Craig Anderson et al.   LANCET NEUROLOGY

Angiotensin II induced cerebral microvascular inflammation and increased blood–brain barrier permeability via oxidative stress

(2010) M. Zhang et al.   NEUROSCIENCE

Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease

(2010) Lusine Danielyan et al.   REJUVENATION RESEARCH

Angiotensin II, mitochondria, cytoskeletal, and extracellular matrix connections: an integrating viewpoint

(2009) Elena MV de Cavanagh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Angiotensin-Converting Enzyme Inhibitors and Cognitive Decline in Older Adults With Hypertension

(2009) Kaycee M. Sink et al.   ARCHIVES OF INTERNAL MEDICINE

Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors

(2009) Albert Fournier et al.   Expert Review of Neurotherapeutics

Cognitive Deficit in Amyloid-β–Injected Mice Was Improved by Pretreatment With a Low Dose of Telmisartan Partly Because of Peroxisome Proliferator-Activated Receptor-γ Activation

(2009) Kana Tsukuda et al.   HYPERTENSION

Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling

(2009) Shuko Takeda et al.   HYPERTENSION

Angiotensin II Modulates BBB Permeability via Activation of the AT1 Receptor in Brain Endothelial Cells

(2009) Melissa A Fleegal-DeMotta et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Examination of the current top candidate genes for AD in a genome-wide association study

(2009) T M Feulner et al.   MOLECULAR PSYCHIATRY

Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons

(2009) L. B. Hoffman et al.   NEUROLOGY

Angiotensins in Alzheimer's disease – friend or foe?

(2009) Patrick G. Kehoe et al.   TRENDS IN NEUROSCIENCES

Candesartan improves memory decline in mice: Involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin

(2008) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

Telmisartan prevented cognitive decline partly due to PPAR-γ activation

(2008) Masaki Mogi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ-Degrading Enzymes in Alzheimer's Disease

(2008) James Scott Miners et al.   BRAIN PATHOLOGY

Orally Active Aminopeptidase A Inhibitors Reduce Blood Pressure

(2008) Laurence Bodineau et al.   HYPERTENSION

Renin-angiotensin system revisited

(2008) F. Fyhrquist et al.   JOURNAL OF INTERNAL MEDICINE

Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial

(2008) Ruth Peters et al.   LANCET NEUROLOGY

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction

(2007) Abdulrahman K. Doughan et al.   CIRCULATION RESEARCH

Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy

(2007) J. S. Miners et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY