Central Angiotensin II Stimulation Promotes β Amyloid Production in Sprague Dawley Rats

Angiotensin II-induced upregulation of AT1 receptor expression: sequential activation of NF-κB and Elk-1 in neurons

(2010) Amit K. Mitra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Blocking β2-adrenergic receptor attenuates acute stress-induced amyloid β peptides production

(2010) Nan-Nan Yu et al.   BRAIN RESEARCH

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

Synaptic and Endosomal Localization of Active γ-Secretase in Rat Brain

(2010) Susanne Frykman et al.   PLoS One

Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease

(2010) Lusine Danielyan et al.   REJUVENATION RESEARCH

Inflammation in the Alzheimer's disease cascade: culprit or innocent bystander?

(2010) Zaldy S Tan et al.   Alzheimers Research & Therapy

Angiotensin II upregulates hypothalamic AT1 receptor expression in rats via the mitogen-activated protein kinase pathway

(2009) Shun-Guang Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Alzheimer disease: Time to improve its diagnosis and treatment

(2009) S. SALLOWAY et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Glucocorticoids increase impairments in learning and memory due to elevated amyloid precursor protein expression and neuronal apoptosis in 12-month old mice

(2009) Wei-Zu Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling

(2009) Shuko Takeda et al.   HYPERTENSION

Depletion of Vitamin E Increases Amyloid β Accumulation by Decreasing Its Clearances from Brain and Blood in a Mouse Model of Alzheimer Disease

(2009) Yoichiro Nishida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linking Amyloid and Tau Pathology in Alzheimer's Disease: The Role of Membrane Cholesterol in A -Mediated Tau Toxicity

(2009) S. Wray et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2009) Lennart Mucke   NATURE

Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of α-, β- and γ-secretase expression

(2009) Ricardo Quiroz-Baez et al.   NEUROCHEMISTRY INTERNATIONAL

Adverse Stress, Hippocampal Networks, and Alzheimer’s Disease

(2009) Sarah M. Rothman et al.   NEUROMOLECULAR MEDICINE

Modulation of  -secretase specificity using small molecule allosteric inhibitors

(2009) C. C. Shelton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Orphan G Protein-Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons

(2009) A. Thathiah et al.   SCIENCE

Candesartan improves memory decline in mice: Involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin

(2008) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

Telmisartan prevented cognitive decline partly due to PPAR-γ activation

(2008) Masaki Mogi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of basal activity of c-jun-NH2-terminal kinase (JNK) represses the expression of presenilin-1 by a p53-dependent mechanism

(2008) Sebum Lee et al.   BRAIN RESEARCH

Effects of intracerebroventricular infusion of angiotensin-(1–7) on bradykinin formation and the kinin receptor expression after focal cerebral ischemia–reperfusion in rats

(2008) Jie Lu et al.   BRAIN RESEARCH

A Closer Look at α-Secretase

(2008) Rolf Postina   Current Alzheimer Research

Mitogen-Activated Protein Kinases Mediate Upregulation of Hypothalamic Angiotensin II Type 1 Receptors in Heart Failure Rats

(2008) Shun-Guang Wei et al.   HYPERTENSION

Amyloid β-Protein Monomer Folding: Free-Energy Surfaces Reveal Alloform-Specific Differences

(2008) Mingfeng Yang et al.   JOURNAL OF MOLECULAR BIOLOGY

Tumor Necrosis Factor-α–elicited Stimulation of γ-Secretase Is Mediated by c-Jun N-terminal Kinase-dependent Phosphorylation of Presenilin and Nicastrin

(2008) Lan-Hsin Kuo et al.   MOLECULAR BIOLOGY OF THE CELL

Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1

(2008) Donald B Carter et al.   Molecular Neurodegeneration

A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment

(2008) Li Liu et al.   NEUROBIOLOGY OF DISEASE

Effects of Antihypertensive Drug Treatment on the Risk of Dementia and Cognitive Impairment

(2008) Ivy O Poon   PHARMACOTHERAPY