mGluR antagonists and GABA agonists as novel pharmacological agents for the treatment of autism spectrum disorders

Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice

(2012) Aubin Michalon et al.   NEURON

Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism

(2012) J. L. Silverman et al.   Science Translational Medicine

Alterations in GABAergic Biomarkers in the Autism Brain: Research Findings and Clinical Implications

(2011) Gene J. Blatt et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

The neurochemical basis for the treatment of autism spectrum disorders and Fragile X Syndrome

(2011) David R. Hampson et al.   BIOCHEMICAL PHARMACOLOGY

Complex effects of mGluR5 antagonism on sociability and stereotypic behaviors in mice: Possible implications for the pharmacotherapy of autism spectrum disorders

(2011) Jessica A. Burket et al.   BRAIN RESEARCH BULLETIN

Pathways to Drug Development for Autism Spectrum Disorders

(2011) D R Hampson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The neurology of autism spectrum disorders

(2011) Shafali S Jeste   CURRENT OPINION IN NEUROLOGY

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056

(2011) S. Jacquemont et al.   Science Translational Medicine

Alterations of GABAergic Signaling in Autism Spectrum Disorders

(2011) Rocco Pizzarelli et al.   NEURAL PLASTICITY

Pharmacological reversal of synaptic plasticity deficits in the mouse model of Fragile X syndrome by group II mGluR antagonist or lithium treatment

(2010) Catherine H. Choi et al.   BRAIN RESEARCH

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

(2010) Hsiao-Tuan Chao et al.   NATURE

A pilot open label, single dose trial of fenobam in adults with fragile X syndrome

(2009) E Berry-Kravis et al.   JOURNAL OF MEDICAL GENETICS

Fragile x syndrome and autism: from disease model to therapeutic targets

(2009) Gül Dölen et al.   Journal of Neurodevelopmental Disorders

Increased GABAB Receptor-Mediated Signaling Reduces the Susceptibility of Fragile X Knockout Mice to Audiogenic Seizures

(2009) L. K. K. Pacey et al.   MOLECULAR PHARMACOLOGY

Repetitive Self-Grooming Behavior in the BTBR Mouse Model of Autism is Blocked by the mGluR5 Antagonist MPEP

(2009) Jill L Silverman et al.   NEUROPSYCHOPHARMACOLOGY

Syndromic autism: causes and pathogenetic pathways

(2009) Arianna Benvenuto et al.   World Journal of Pediatrics

The Autistic Neuron: Troubled Translation?

(2008) Raymond J. Kelleher et al.   CELL

Inactivation of the Maternal Fragile X Gene Results in Sensitization of GABAB Receptor Function in the Offspring

(2008) B. Zupan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila

(2008) Shuang Chang et al.   Nature Chemical Biology

Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis

(2008) Dan Ehninger et al.   NATURE MEDICINE