ADME pharmacogenetics: current practices and future outlook

Pharmacogenomics of warfarin: Uncovering a piece of the warfarin mystery

(2009) M. P. Gulseth et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

A Rapid-ACCE review of CYP2C9 and VKORC1 alleles testing to inform warfarin dosing in adults at elevated risk for thrombotic events to avoid serious bleeding

(2009) Monica R McClain et al.   GENETICS IN MEDICINE

Can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan? An evidence-based review

(2009) Glenn E Palomaki et al.   GENETICS IN MEDICINE

Effect of Cytochrome P450 Polymorphisms on Platelet Reactivity After Treatment With Clopidogrel in Acute Coronary Syndrome

(2008) Corinne Frere et al.   AMERICAN JOURNAL OF CARDIOLOGY

The Use of Genomics in Clinical Trial Design

(2008) R. Simon   CLINICAL CANCER RESEARCH

The Effect of CYP2C19 Polymorphism on the Pharmacokinetics and Pharmacodynamics of Clopidogrel: A Possible Mechanism for Clopidogrel Resistance

(2008) KA Kim et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacokinetics/Genotype Associations for Major Cytochrome P450 Enzymes in Native and First- and Third-generation Japanese Populations: Comparison With Korean, Chinese, and Caucasian Populations

(2008) SP Myrand et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genetic determinants of variable metabolism have little impact on the clinical use of leading antipsychotics in the CATIE study

(2008) Iris Grossman et al.   GENETICS IN MEDICINE

PhRMA White Paper on ADME Pharmacogenomics

(2008) J. Andrew Williams et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Cytochrome P450 2C19 681G>A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous Coronary Intervention With Drug-Eluting or Bare-Metal Stents

(2008) Dietmar Trenk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clopidogrel in acute coronary syndrome: to genotype or not?

(2008) Robert F Storey   LANCET

Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study

(2008) Jean-Philippe Collet et al.   LANCET

Defining drug disposition determinants: a pharmacogenetic–pharmacokinetic strategy

(2008) David A. Katz et al.   NATURE REVIEWS DRUG DISCOVERY

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS

Polymorphisms in the Drug Transporter Gene ABCB1 Predict Antidepressant Treatment Response in Depression

(2008) Manfred Uhr et al.   NEURON

Brain Drug-Metabolizing Cytochrome P450 Enzymes are Active In Vivo, Demonstrated by Mechanism-Based Enzyme Inhibition

(2008) Sharon Miksys et al.   NEUROPSYCHOPHARMACOLOGY

Cytochrome P-450 Polymorphisms and Response to Clopidogrel

(2008) Jessica L. Mega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Determinants of Response to Clopidogrel and Cardiovascular Events

(2008) Tabassome Simon et al.   NEW ENGLAND JOURNAL OF MEDICINE

CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation

(2008) Tobias Geisler et al.   PHARMACOGENOMICS

Drug–diagnostic codevelopment strategies: FDA and industry dialog at the 4th FDA/DIA/PhRMA/PWG/BIO Pharmacogenomics Workshop

(2008) Lois Hinman et al.   PHARMACOGENOMICS

Designing pharmacogenetic projects in industry: practical design perspectives from the Industry Pharmacogenomics Working Group

(2008) C M Bromley et al.   PHARMACOGENOMICS JOURNAL

Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition

(2008) S.-F. Zhou   XENOBIOTICA

Global analysis of genetic variation in SLCO1B1

(2007) Marja K Pasanen et al.   PHARMACOGENOMICS

Biological effect of increased maintenance dose of clopidogrel in cardiovascular outpatients and influence of the cytochrome P450 2C19⁎2 allele on clopidogrel responsiveness

(2007) Pierre Fontana et al.   THROMBOSIS RESEARCH