Article
Chemistry, Medicinal
Pureum Kang, Chang-Keun Cho, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee, Chang-Ik Choi, Jung-Woo Bae
Summary: The study investigated the effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide. The results showed that CYP2C9 and CYP2C19 genetic polymorphisms significantly affected the pharmacokinetics of gliclazide. However, the effects on plasma glucose and insulin responses were not significant, suggesting further research is needed.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Hui Wu, Xinli Chen, Yongli Ding, Yanglin Deng, Ruilan Ma, Xinyuan Chen, Xuesong Li
Summary: This study found an association between plasma concentration of clopidogrel active metabolites (CAM) and CYP2C19 genetic polymorphism with clopidogrel resistance (CR). Patients with extensive metabolism (EMs) had lower incidence of CR compared to intermediate metabolizers (IMs) and poor metabolizers (PMs). In addition, the incidence of chest tightness was higher in IMs and PMs groups compared to the EMs group, and both CYP2C19 and plasma concentration of CAM were related to the incidence of chest tightness.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Guo-Xian Shi, Zi-He Zhao, Xiao-Yan Yang, Mu Lin, Zhou-Xue Chen
Summary: This study found a higher occurrence rate of clopidogrel resistance in Han Chinese patients with cerebral infarction in Guizhou region, which is correlated with CYP2C19 gene polymorphism and blood lipid level. Independent risk factors for clopidogrel resistance include history of diabetes, history of high blood pressure, increase in low density lipoprotein, and CYP2C19 mutant gene.
Review
Pharmacology & Pharmacy
Alicia Rodriguez-Gascon, Maria angeles Solinis, Arantxa Isla
Summary: PK/PD analysis is essential in establishing rational dosage regimens of antimicrobial agents in human and veterinary medicine. It involves the use of different models and mathematical models to determine optimal dosing regimens and prevent the emergence of resistance. PK/PD analysis plays a crucial role in the development of new antibiotics and optimization of current drug dosage regimens.
Article
Cardiac & Cardiovascular Systems
Nick D. Fagel, Giovanni Amoroso, Maarten A. Vink, Ton Slagboom, Rene J. van der Scaaf, Jean-Paul Herrman, Mark S. Patterson, Erik F. J. Oosterwerff, Nicola S. Vos, Freek W. A. Verheugt, Jan G. P. Tijssen, Robbert J. de Winter, Robert K. Riezebos
Summary: The study randomized NSTE-ACS patients to either an immediate or early invasive treatment strategy, showing that the observed median difference in the primary endpoint between the immediate and early group was about half of the expected difference, leading to early termination of the trial due to futility.
AMERICAN HEART JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Lin Zhang, Hongbin Sun, Yongqiang Liu, Xiaojuan Lai, Yanchun Gong, Xuefang Liu, Yong-guo Li, Yang He, Eric Y. Zhang, Xiaoyu Yan
Summary: This study developed a semi-mechanistic population pharmacokinetic model to characterize the pharmacokinetic profile of M15-2, the active metabolite of vicagrel and clopidogrel. It was found that the bioactivation of vicagrel is more efficient and less dependent on CYP2C19 than that of clopidogrel, suggesting that vicagrel may reduce the complexity of currently recommended CYP2C19-based dosage adjustment for clopidogrel.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Ji-Young Byeon, Chang-Keun Cho, Pureum Kang, Se-Hyung Kim, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee
Summary: This study investigated the impact of genetic polymorphisms of CYP2D6 and CYP2C19, as well as cigarette smoking, on the pharmacokinetics of tolperisone. The results showed that these factors independently affected tolperisone metabolism, and their combined effects had a greater impact.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ting-jian Zhang, Xu Zhang, En-yu Xu, Zhao-ran Wang, Zhen-hao Zhang, Qiu-yin Wang, Lin Wang, Yan-qing Wen, Fan-hao Meng
Summary: TS10 is a novel amide-based xanthine oxidase inhibitor that exhibits comparable inhibition activity to topiroxostat. It has the ability to covalently bind with xanthine oxidase and demonstrates significant uric acid-lowering effect.
BIOORGANIC CHEMISTRY
(2022)
Review
Medicine, General & Internal
Ivana Budic, Tatjana Jevtovic Stoimenov, Dimitrije Pavlovic, Vesna Marjanovic, Ivona Djordjevic, Marija Stevic, Dusica Simic
Summary: Individual variability in response to anesthesia drugs is common and influenced by genetic and environmental factors. Propofol, the most common intravenous anesthetic, can be affected by genetic factors such as gene polymorphisms. However, there is a need for further research on multiple pathways to understand the individual differences in propofol pharmacokinetics and pharmacodynamics.
FRONTIERS IN MEDICINE
(2022)
Article
Chemistry, Medicinal
Chang-Keun Cho, Ji-Young Byeon, Pureum Kang, Hye-Jung Park, Eunvin Ko, Chou Yen Mu, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee
Summary: Tolperisone hydrochloride is a centrally-acting muscle relaxant that is used to relieve spasticities and muscle spasms. The pharmacokinetics of tolperisone are significantly affected by the genetic polymorphism of CYP2C19, resulting in higher plasma concentration and lower clearance values in individuals with the CYP2C19PM genotype.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Nam-Tae Kim, Chang-Keun Cho, Pureum Kang, Hye-Jung Park, Yun Jeong Lee, Jung-Woo Bae, Choon-Gon Jang, Seok-Yong Lee
Summary: The CYP2C9*3 and *13 alleles significantly affect the pharmacokinetics of glipizide, resulting in elevated plasma concentrations of the drug. Individuals with the CYP2C9*3 and *13 genotypes show a significant increase in mean AUC(0-infinity) of glipizide compared to those with the wild-type CYP2C9*1/*1 genotype, while the effects of glipizide on plasma glucose and insulin levels are not significantly different among CYP2C9 genotype groups.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Gunavanthi D. Boorgula, Laxmi U. M. R. Jakkula, Tawanda Gumbo, Bockgie Jung, Shashikant Srivastava
Summary: The study compared microbial kill and resistance emergence of different rifamycins in the treatment of pulmonary MAC infection. Results showed no significant difference in efficacy and resistance suppression among the three rifamycins tested, and monotherapy with rifamycins was ineffective and led to drug resistance development.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Clinical Neurology
Luciano A. Sposato, Geoffrey Alan Donnan
Summary: Clopidogrel is commonly used for secondary stroke prevention and its activation relies on CYP2C19-mediated oxidation process. Various CYP2C19 polymorphisms with different metabolic activities have been identified, including CYP2C19*2 and CYP2C19*3 which are well-characterized loss-of-function alleles. Homozygous and heterozygous carriers of these alleles are considered poor and intermediate metabolizers, respectively. Ischemic stroke and TIA patients with CYP2C19 loss-of-function alleles exhibit increased clopidogrel resistance and higher stroke recurrence rates.
Review
Infectious Diseases
Erlangga Yusuf, Markus Zeitlinger, Sylvain Meylan
Summary: The interpretation of antimicrobial susceptibility testing results (S or R) is clear, but the "intermediate (I)" category poses difficulties. This review critically examines how clinical breakpoints are determined using pharmacokinetics and pharmacodynamics. It discusses the discrepancies in the "I" category between CLSI and EUCAST, and the recent changes in EUCAST definition and their impact on laboratory and clinical practices.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Marcus Tindall, Michael J. Chappell, James W. T. Yates
Summary: Mathematical modelling has played a significant role in optimizing the use of antimicrobial treatments. This article discusses the key processes that should be captured by such modelling, with a particular emphasis on quantifying the response of the host immune system and presenting a novel model structure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Pharmacology & Pharmacy
Sang-In Park, Ji-Young Park, Min-Ju Park, Sung-Vin Yim, Bo-Hyung Kim
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Sue In Choi, Seung Hyeun Lee, Ji-Young Park, Kyoung-Ah Kim, Eun Joo Lee, Sang Yeub Lee, Kwang Ho In
ONCOTARGETS AND THERAPY
(2019)
Article
Pharmacology & Pharmacy
Jin-Woo Park, Kyoung-Ah Kim, Yong Il Kim, Ji-Young Park
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2019)
Article
Pharmacology & Pharmacy
Sang-In Park, Ji-Young Park, Ji Hyun Lee, Mun Su Park, Kyung-Tae Lee, Sung-Vin Yim, Young-Ran Yoon, Bo-Hyung Kim
JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Jin-Woo Park, Kyoung-Ah Kim, Ji-Young Park
JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Jin-Woo Park, Kyoung-Ah Kim, Yun Jung Choi, Soo Hyun Yoon, Ji-Young Park
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2019)
Article
Biochemical Research Methods
Jin-Woo Park, Kyoung-Ah Kim, Ji-Young Park
BIOMEDICAL CHROMATOGRAPHY
(2020)
Article
Pharmacology & Pharmacy
Jin-Woo Park, Kyoung-Ah Kim, Hankil Son, Jina Jung, Ji-Young Park
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
(2020)
Article
Integrative & Complementary Medicine
Jin-Woo Park, Kyoung-Ah Kim, Min-Goo Lee, Ji-Young Park
Summary: Short-term sunlight exposure significantly reduces blood pressure and pulse rate in vitamin D3-insufficient, prehypertensive patients, with more pronounced effects observed during nighttime. Furthermore, post-sunlight exposure, levels of 25-hydroxyvitamin D3 significantly increased, while aldosterone levels significantly decreased.
COMPLEMENTARY MEDICINE RESEARCH
(2021)