Advances in the arsenal of tools available enabling the discovery of novel lantibiotics with therapeutic potential

Heterologous Expression and Engineering Studies of Labyrinthopeptins, Class III Lantibiotics from Actinomadura namibiensis

(2013) Joanna M. Krawczyk et al.   CHEMISTRY & BIOLOGY

Cloning and Analysis of the Planosporicin Lantibiotic Biosynthetic Gene Cluster of Planomonospora alba

(2013) E. J. Sherwood et al.   JOURNAL OF BACTERIOLOGY

Chemical Synthesis of the Lantibiotic Lacticin 481 Reveals the Importance of Lanthionine Stereochemistry

(2013) Patrick J. Knerr et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

BAGEL3: automated identification of genes encoding bacteriocins and (non-)bactericidal posttranslationally modified peptides

(2013) Auke J. van Heel et al.   NUCLEIC ACIDS RESEARCH

Designing and Producing Modified, New-to-Nature Peptides with Antimicrobial Activity by Use of a Combination of Various Lantibiotic Modification Enzymes

(2013) Auke J. van Heel et al.   ACS Synthetic Biology

Gene cluster analysis for the biosynthesis of elgicins, novel lantibiotics produced by paenibacillus elgii B69

(2012) Yi Teng et al.   BMC MICROBIOLOGY

Characterization of New Class III Lantibiotics-Erythreapeptin, Avermipeptin and Griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus Demonstrates Stepwise N-Terminal Leader Processing

(2012) Ginka H. Völler et al.   CHEMBIOCHEM

Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli

(2012) Yanxiang Shi et al.   CHEMICAL COMMUNICATIONS

Synthetic Biotechnology to Study and Engineer Ribosomal Bottromycin Biosynthesis

(2012) Liujie Huo et al.   CHEMISTRY & BIOLOGY

Evaluation of NVB302 versus vancomycin activity in an in vitro human gut model of Clostridium difficile infection

(2012) G. S. Crowther et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Primer on Agar-Based Microbial Imaging Mass Spectrometry

(2012) J. Y. Yang et al.   JOURNAL OF BACTERIOLOGY

An Engineered Lantibiotic Synthetase That Does Not Require a Leader Peptide on Its Substrate

(2012) Trent J. Oman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Synthesis of Active and Stable Diaminopimelate Analogues of the Lantibiotic Peptide Lactocin S

(2012) Avena C. Ross et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Identification and isolation of lantibiotics from culture: a bioorthogonal chemistry approach

(2012) Jing Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A High-Throughput Screen Identifies a New Natural Product with Broad-Spectrum Antibacterial Activity

(2012) Patrick Ymele-Leki et al.   PLoS One

Evolution of lanthipeptide synthetases

(2012) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lantibiotics from Geobacillus thermodenitrificans

(2012) N. Garg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

(2012) M. F. Freeman et al.   SCIENCE

Efficacy of the New Lantibiotic NAI-107 in Experimental Infections Induced by Multidrug-Resistant Gram-Positive Pathogens

(2011) Daniela Jabés et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synergistic Drug Combinations for Tuberculosis Therapy Identified by a Novel High-Throughput Screen

(2011) Santiago Ramón-García et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacterial Display and Screening of Posttranslationally Thioether-Stabilized Peptides

(2011) Tjibbe Bosma et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Leader Peptide-Directed Processing of Labyrinthopeptin A2 Precursor Peptide by the Modifying Enzyme LabKC

(2011) Wolfgang M. Müller et al.   BIOCHEMISTRY

Identification of the amino acid labionin and its desulfurised derivative in the type-III lantibiotic LabA2 by means of GC/MS

(2011) Alexander Pesic et al.   CHEMICAL COMMUNICATIONS

Heterologous Expression, Biosynthesis, and Mutagenesis of Type II Lantibiotics from Bacillus licheniformis in Escherichia coli

(2011) Tânia Caetano et al.   CHEMISTRY & BIOLOGY

Haloduracin α Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry

(2011) Trent J. Oman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solid Supported Chemical Syntheses of Both Components of the Lantibiotic Lacticin 3147

(2011) Wei Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Target recognition, resistance, immunity and genome mining of class II bacteriocins from Gram-positive bacteria

(2011) M. Kjos et al.   MICROBIOLOGY-SGM

A mass spectrometry–guided genome mining approach for natural product peptidogenomics

(2011) Roland D Kersten et al.   Nature Chemical Biology

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

Synthesis of Peptides Containing Overlapping Lanthionine Bridges on the Solid Phase: An Analogue of Rings D and E of the Lantibiotic Nisin

(2011) Begum Mothia et al.   ORGANIC LETTERS

Detection of putative new mutacins by bioinformatic analysis using available web tools

(2011) Guillaume G Nicolas   BioData Mining

Production of a Class II Two-Component Lantibiotic of Streptococcus pneumoniae Using the Class I Nisin Synthetic Machinery and Leader Sequence

(2010) J. A. Majchrzykiewicz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Microbial engineering of dehydro-amino acids and lanthionines in non-lantibiotic peptides

(2010) Gert N. Moll et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

BACTIBASE second release: a database and tool platform for bacteriocin characterization

(2010) Riadh Hammami et al.   BMC MICROBIOLOGY

Genome mining for ribosomally synthesized natural products

(2010) Juan E Velásquez et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

High-throughput discovery of broad-spectrum peptide antibiotics

(2010) Ramesh Rathinakumar et al.   FASEB JOURNAL

Genome Sequence of the Polymyxin-Producing Plant-Probiotic Rhizobacterium Paenibacillus polymyxa E681

(2010) J. F. Kim et al.   JOURNAL OF BACTERIOLOGY

Complete Genome Sequence of Paenibacillus polymyxa SC2, a Strain of Plant Growth-Promoting Rhizobacterium with Broad-Spectrum Antimicrobial Activity

(2010) M. Ma et al.   JOURNAL OF BACTERIOLOGY

Production of Lantipeptides inEscherichia coli

(2010) Yanxiang Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The dawning of a ‘Golden era’ in lantibiotic bioengineering

(2010) Des Field et al.   MOLECULAR MICROBIOLOGY

Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights

(2010) Yuki Goto et al.   PLOS BIOLOGY

Milk Protein Fragments Induce the Biosynthesis of Macedocin, the Lantibiotic Produced by Streptococcus macedonicus ACA-DC 198

(2009) M. Georgalaki et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification of a Novel Two-Peptide Lantibiotic, Lichenicidin, following Rational Genome Mining for LanM Proteins

(2009) M. Begley et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Strategies for the Discovery of New Natural Products by Genome Mining

(2009) Malek Zerikly et al.   CHEMBIOCHEM

Dissecting Structural and Functional Diversity of the Lantibiotic Mersacidin

(2009) Antony N. Appleyard et al.   CHEMISTRY & BIOLOGY

Emerging Treatments in Cystic Fibrosis

(2009) Andrew M. Jones et al.   DRUGS

Pharmacokinetic and pharmacodynamic evaluation of the lantibiotic MU1140

(2009) Oliver Ghobrial et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

In Vitro Mutasynthesis of Lantibiotic Analogues Containing Nonproteinogenic Amino Acids

(2009) Matthew R. Levengood et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organization of the genes encoding the biosynthesis of actagardine and engineering of a variant generation system

(2009) Steven Boakes et al.   MOLECULAR MICROBIOLOGY

Follow the leader: the use of leader peptides to guide natural product biosynthesis

(2009) Trent J Oman et al.   Nature Chemical Biology

Dereplication and de novo sequencing of nonribosomal peptides

(2009) Julio Ng et al.   NATURE METHODS

Production of the Novel Two-Peptide Lantibiotic Lichenicidin by Bacillus licheniformis DSM 13

(2009) Jasmin Dischinger et al.   PLoS One

The Vancomycin−Nisin(1−12) Hybrid Restores Activity against Vancomycin Resistant Enterococci†

(2008) Christopher J. Arnusch et al.   BIOCHEMISTRY

The Importance of the Leader Sequence for Directing Lanthionine Formation in Lacticin 481†

(2008) Gregory C. Patton et al.   BIOCHEMISTRY

Elucidation of the Antimicrobial Mechanism of Mutacin 1140

(2008) Leif Smith et al.   BIOCHEMISTRY

Determining the Structure and Mode of Action of Microbisporicin, a Potent Lantibiotic Active Against Multiresistant Pathogens

(2008) Franca Castiglione et al.   CHEMISTRY & BIOLOGY

Pharmacodynamic activity of the lantibiotic MU1140

(2008) Oliver G. Ghobrial et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Genome Mining for Novel Natural Product Discovery

(2008) Gregory L. Challis   JOURNAL OF MEDICINAL CHEMISTRY

Angiotensin-(1-7) with Thioether Bridge: An Angiotensin-Converting Enzyme-Resistant, Potent Angiotensin-(1-7) Analog

(2008) L. D. Kluskens et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS