Development and application of PI3K assays for novel drug discovery

New in-capillary electrophoretic kinase assays to evaluate inhibitors of the PI3k/Akt/mTOR signaling pathway

(2014) Reine Nehmé et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Development of phosphocellulose paper-based screening of inhibitors of lipid kinases: Case study with PI3Kβ

(2014) Mahesh Yanamandra et al.   ANALYTICAL BIOCHEMISTRY

Targeting the PI3K/mTOR Pathway in Pediatric Hematologic Malignancies

(2014) Sarah K. Tasian et al.   Frontiers in Oncology

Inhibition of phosphoinositide 3-kinase γ attenuates inflammation, obesity, and cardiovascular risk factors

(2013) Matthias P. Wymann et al.   Annals of the New York Academy of Sciences

Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells

(2013) Klaus Okkenhaug   Annual Review of Immunology

LY294002 Induces G0/G1 Cell Cycle Arrest and Apoptosis of Cancer Stem-like Cells from Human Osteosarcoma Via Down-regulation of PI3K Activity

(2013) Chen Gong et al.   Asian Pacific Journal of Cancer Prevention

A Homogeneous, High-Throughput Assay for Phosphatidylinositol 5-Phosphate 4-Kinase with a Novel, Rapid Substrate Preparation

(2013) Mindy I. Davis et al.   PLoS One

PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances

(2012) Lomon So et al.   BIOCHEMICAL JOURNAL

Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment

(2012) Irene Brana et al.   BMC Medicine

Current clinical development of PI3K pathway inhibitors in glioblastoma

(2012) P. Y. Wen et al.   NEURO-ONCOLOGY

Kinetic analysis of PI3K reactions with fluorescent PIP2 derivatives

(2011) Weigang Huang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Small-molecule inhibitors of the PI3K signaling network

(2011) Colleen R McNamara et al.   Future Medicinal Chemistry

PI3K Inhibitors in Cardiovascular Disease

(2010) Andreas Eisenreich et al.   Cardiovascular Therapeutics

Fluorescence polarization assays in small molecule screening

(2010) Wendy A Lea et al.   Expert Opinion on Drug Discovery

The PI3K Pathway As Drug Target in Human Cancer

(2010) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

Evaluating the Utility of a Bioluminescent ADP-Detecting Assay for Lipid Kinases

(2009) Jolanta Vidugiriene et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Phosphoinositide 3-kinases and their role in inflammation: potential clinical targets in atherosclerosis?

(2009) Anne Fougerat et al.   CLINICAL SCIENCE

PI3Kγ regulates cartilage damage in chronic inflammatory arthritis

(2009) Silvia Hayer et al.   FASEB JOURNAL

Characterization of PI3K class IA isoforms with regulatory subunit p55α using a scintillation proximity assay

(2008) Glenn S. Van Aller et al.   ANALYTICAL BIOCHEMISTRY

Scintillation Proximity Assays in High-Throughput Screening

(2008) J. Fraser Glickman et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Phosphoinositide 3-kinase signalling in the vascular system

(2008) F. Morello et al.   CARDIOVASCULAR RESEARCH

The challenge of selecting protein kinase assays for lead discovery optimization

(2008) Haiching Ma et al.   Expert Opinion on Drug Discovery