The many facets of PEDF in drug discovery and disease: a diamond in the rough or split personality disorder?
出版年份 2013 全文链接
标题
The many facets of PEDF in drug discovery and disease: a diamond in the rough or split personality disorder?
作者
关键词
-
出版物
Expert Opinion on Drug Discovery
Volume 8, Issue 7, Pages 769-792
出版商
Informa Healthcare
发表日期
2013-05-06
DOI
10.1517/17460441.2013.794781
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Pigment Epithelium-Derived Factor Blocks Tumor Extravasation by Suppressing Amoeboid Morphology and Mesenchymal Proteolysis
- (2015) Omar Ladhani et al. NEOPLASIA
- Neural Stem Cell Niches and Homing: Recruitment and Integration into Functional Tissues
- (2013) T. Garzon-Muvdi et al. ILAR JOURNAL
- Unknown
- (2013) Yanling Liu et al. MOLECULAR MEDICINE
- Insulin resistance is associated with elevated serum pigment epithelium–derived factor (PEDF) levels in morbidly obese patients
- (2012) Arijeet K. Gattu et al. ACTA DIABETOLOGICA
- Treating early choroidal neovascularisation with pegaptanib sodium in patients with neovascular age-related macular degeneration: Findings of the PERSPECTIVES study
- (2012) Usha Chakravarthy et al. BRITISH JOURNAL OF OPHTHALMOLOGY
- Measuring the benefit of 4 years of intravitreal ranibizumab treatment for neovascular age-related macular degeneration
- (2012) Sreekumari Pushpoth et al. BRITISH JOURNAL OF OPHTHALMOLOGY
- Assessing the in vivo efficacy of biologic antiangiogenic therapies
- (2012) Peter M. Wilson et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Opposing Effects of Pigment Epithelium-Derived Factor on Breast Cancer Cell versus Neuronal Survival: Implication for Brain Metastasis and Metastasis-Induced Brain Damage
- (2012) D. P. Fitzgerald et al. CANCER RESEARCH
- Serum levels of pigment epithelium-derived factor, a novel marker of insulin resistance, are independently associated with fasting apolipoprotein B48 levels in humans
- (2012) Nobuhiro Tahara et al. CLINICAL BIOCHEMISTRY
- Pigment epithelium-derived factor increases in type 2 diabetes after treatment with metformin
- (2012) Şafak Akın et al. CLINICAL ENDOCRINOLOGY
- C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients With Type 2 Diabetes and Metabolic Syndrome
- (2012) K. M. Choi et al. DIABETES
- Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice
- (2012) Paul J Grippo et al. GUT
- Efficacy of Continuously Administered PEDF-Derived Synthetic Peptides against Osteosarcoma Growth and Metastasis
- (2012) Matthew L. Broadhead et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- The Emerging Role of PEDF in Stem Cell Biology
- (2012) Mina Elahy et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Cell and Molecular Biology Underpinning the Effects of PEDF on Cancers in General and Osteosarcoma in Particular
- (2012) Vijay Chandolu et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Lack of Circulating Pigment Epithelium-Derived Factor Is a Marker of Osteogenesis Imperfecta Type VI
- (2012) Frank Rauch et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- PEDF Is a Novel Oligodendrogenic Morphogen Acting on the Adult SVZ and Corpus Callosum
- (2012) J. Sohn et al. JOURNAL OF NEUROSCIENCE
- Pigment Epithelium-Derived Factor Released by Müller Glial Cells Exerts Neuroprotective Effects on Retinal Ganglion Cells
- (2012) Jan Darius Unterlauft et al. NEUROCHEMICAL RESEARCH
- Positive correlation between PEDF expression levels and macrophage density in the human prostate
- (2012) Thomas Nelius et al. PROSTATE
- Pigment epithelium-derived factor is related to macular microcirculation in patients with macular edema and branch retinal vein occlusion
- (2012) Hidetaka Noma et al. INTERNATIONAL OPHTHALMOLOGY
- Exome Sequencing Identifies Truncating Mutations in Human SERPINF1 in Autosomal-Recessive Osteogenesis Imperfecta
- (2011) Jutta Becker et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Administration of Pigment Epithelium-Derived Factor Inhibits Left Ventricular Remodeling and Improves Cardiac Function in Rats with Acute Myocardial Infarction
- (2011) Shin-ichiro Ueda et al. AMERICAN JOURNAL OF PATHOLOGY
- Overexpression of Pigment Epithelium–Derived Factor Inhibits Retinal Inflammation and Neovascularization
- (2011) Kyoungmin Park et al. AMERICAN JOURNAL OF PATHOLOGY
- Serum level of pigment epithelium-derived factor is a marker of atherosclerosis in humans
- (2011) Nobuhiro Tahara et al. ATHEROSCLEROSIS
- miR-27b controls venous specification and tip cell fate
- (2011) D. Biyashev et al. BLOOD
- Hypoxia in the regulation of neural stem cells
- (2011) Lidia De Filippis et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Pigment Epithelium-Derived Factor Regulates Lipid Metabolism via Adipose Triglyceride Lipase
- (2011) M. L. Borg et al. DIABETES
- The ratio of VEGF/PEDF expression in bone marrow mesenchymal stem cells regulates neovascularization
- (2011) Wei Fan et al. DIFFERENTIATION
- A PEDF-Derived Peptide Inhibits Retinal Neovascularization and Blocks Mobilization of Bone Marrow-Derived Endothelial Progenitor Cells
- (2011) Richard Longeras et al. Experimental Diabetes Research
- Pigment Epithelium-derived Factor (PEDF) Promotes Tumor Cell Death by Inducing Macrophage Membrane Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)
- (2011) Tsung-Chuan Ho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pigment Epithelium-derived Factor (PEDF) Shares Binding Sites in Collagen with Heparin/Heparan Sulfate Proteoglycans
- (2011) Atsushi Sekiya et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lack of expression ofSERPINF1, the gene coding for pigment epithelium-derived factor, causes progressively deforming osteogenesis imperfecta with normal type I collagen
- (2011) Giacomo Venturi et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Identification of a Novel Inhibitor of the Canonical Wnt Pathway
- (2011) K. Park et al. MOLECULAR AND CELLULAR BIOLOGY
- The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease
- (2011) Inge Seim et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Toxicity as a Biomarker of Efficacy of Molecular Targeted Therapies: Focus on EGFR and VEGF Inhibiting Anticancer Drugs
- (2011) R. Dienstmann et al. ONCOLOGIST
- Cigarette Smoke-Related Hydroquinone Dysregulates MCP-1, VEGF and PEDF Expression in Retinal Pigment Epithelium in Vitro and in Vivo
- (2011) Marianne Pons et al. PLoS One
- PEDF Regulates Vascular Permeability by a γ-Secretase-Mediated Pathway
- (2011) Jun Cai et al. PLoS One
- Pigment Epithelium-Derived Factor (PEDF) Interacts with Transportin SR2, and Active Nuclear Import Is Facilitated by a Novel Nuclear Localization Motif
- (2011) Sergio Anguissola et al. PLoS One
- Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23 27 24 clusters
- (2011) Q. Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pigment Epithelial-Derived Factor and Melanoma Differentiation Associated Gene-7 Cytokine Gene Therapies Delivered by Adipose-Derived Stromal/Mesenchymal Stem Cells are Effective in Reducing Prostate Cancer Cell Growth
- (2011) Olga Zolochevska et al. STEM CELLS AND DEVELOPMENT
- Cation trapping by cellular acidic compartments: Beyond the concept of lysosomotropic drugs
- (2011) François Marceau et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Urinary Pigment Epithelium-Derived Factor as a Marker of Diabetic Nephropathy
- (2010) Haibing Chen et al. AMERICAN JOURNAL OF NEPHROLOGY
- Anti-chondrosarcoma effects of PEDF mediated via molecules important to apoptosis, cell cycling, adhesion and invasion
- (2010) Mei Lin Tan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- NF- B balances vascular regression and angiogenesis via chromatin remodeling and NFAT displacement
- (2010) A. B. Aurora et al. BLOOD
- Growth suppression of cervical carcinoma by pigment epithelium-derived factor via anti-angiogenesis
- (2010) Jun Yang et al. CANCER BIOLOGY & THERAPY
- Pigment Epithelium-Derived Factor Expression in Colorectal Cancer Patients
- (2010) Dick Wågsäter et al. CANCER INVESTIGATION
- Phosphomimetic Mutants of Pigment Epithelium-Derived Factor with Enhanced Antiangiogenic Activity as Potent Anticancer Agents
- (2010) A. Konson et al. CANCER RESEARCH
- Anti-Atherothrombogenic Properties of PEDF
- (2010) S.-I. Yamagishi et al. CURRENT MOLECULAR MEDICINE
- PEDF in Angiogenic Eye Diseases
- (2010) J. Tombran-Tink CURRENT MOLECULAR MEDICINE
- The Role of PEDF in Tumor Growth and Metastasis
- (2010) D. Hoshina et al. CURRENT MOLECULAR MEDICINE
- The Pathophysiological Role of PEDF in Bone Diseases
- (2010) M.L. Broadhead et al. CURRENT MOLECULAR MEDICINE
- The Neuroprotective Role of PEDF: Implication for the Therapy of Neurological Disorders
- (2010) T. Yabe et al. CURRENT MOLECULAR MEDICINE
- Pigment epithelium-derived factor binds to cell-surface F1-ATP synthase
- (2010) Luigi Notari et al. FEBS Journal
- Pigment epithelium-derived factor and vascular endothelial growth factor in branch retinal vein occlusion with macular edema
- (2010) Hidetaka Noma et al. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
- Pigment Epithelium-Derived Factor Gene Therapy Targeting Retinal Ganglion Cell Injuries: Neuroprotection against Loss of Function in Two Animal Models
- (2010) Masanori Miyazaki et al. HUMAN GENE THERAPY
- Alteration of strain background and a high omega-6 fat diet induces earlier onset of pancreatic neoplasia in EL-Kras transgenic mice
- (2010) Eric C. Cheon et al. INTERNATIONAL JOURNAL OF CANCER
- Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells
- (2010) S Famulla et al. INTERNATIONAL JOURNAL OF OBESITY
- Pigment Epithelium-derived Factor and Its Phosphomimetic Mutant Induce JNK-dependent Apoptosis and p38-mediated Migration Arrest
- (2010) Alexander Konson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Natural Angiogenesis Inhibitor Signals through Erk5 Activation of Peroxisome Proliferator-activated Receptor γ (PPARγ)
- (2010) Dauren Biyashev et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Evaluation of protein pigment epithelium-derived factor (PEDF) and microvessel density (MVD) as prognostic indicators in breast cancer
- (2010) Dan Zhou et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Plasma Level of Pigment Epithelium-Derived Factor Is Independently Associated with the Development of the Metabolic Syndrome in Chinese Men: A 10-Year Prospective Study
- (2010) Cheng Chen et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Circulating Pigment Epithelium-Derived Factor Levels Are Associated with Insulin Resistance and Decrease after Weight Loss
- (2010) Mònica Sabater et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Pigment epithelium-derived factor as a new marker of metabolic syndrome in Caucasian population
- (2010) D. Stejskal et al. JOURNAL OF CLINICAL LABORATORY ANALYSIS
- Antiangiogenic effects and transcriptional regulation of pigment epithelium-derived factor in diabetic retinopathy
- (2010) Binhui Wang et al. MICROVASCULAR RESEARCH
- De-routing neuronal precursors in the adult brain to sites of injury: Role of the vasculature
- (2010) Mireille Massouh et al. NEUROPHARMACOLOGY
- Pigment epithelium-derived factor up-regulation induced by memantine, an N-methyl-d-aspartate receptor antagonist, is involved in increased proliferation of hippocampal progenitor cells
- (2010) T. Namba et al. NEUROSCIENCE
- RETRACTED ARTICLE: PEDF inhibits VEGF- and EPO- induced angiogenesis in retinal endothelial cells through interruption of PI3K/Akt phosphorylation
- (2009) Banumathi Elayappan et al. ANGIOGENESIS
- Modulation of Thrombospondin 1 and Pigment Epithelium–Derived Factor Levels in Vitreous Fluid of Patients With Diabetes
- (2009) Shoujian Wang ARCHIVES OF OPHTHALMOLOGY
- Late Outgrowth Endothelial Cells Derived From Wharton Jelly in Human Umbilical Cord Reduce Neointimal Formation After Vascular Injury
- (2009) Shu-Huei Wang et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Tgfbr1 Haploinsufficiency Inhibits the Development of Murine Mutant Kras-Induced Pancreatic Precancer
- (2009) K. Adrian et al. CANCER RESEARCH
- Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity
- (2009) Seamus Crowe et al. Cell Metabolism
- Short Pigment Epithelial-Derived Factor-Derived Peptide Inhibits Angiogenesis and Tumor Growth
- (2009) Y. Mirochnik et al. CLINICAL CANCER RESEARCH
- Branched-Chain Amino Acids and Pigment Epithelium-Derived Factor: Novel Therapeutic Agents for Hepatitis C Virus-Associated Insulin Resistance
- (2009) T. Kawaguchi et al. CURRENT MEDICINAL CHEMISTRY
- Protective role of pigment epithelium-derived factor (PEDF) in early phase of experimental diabetic retinopathy
- (2009) Yumiko Yoshida et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Pigment epithelium-derived factor (PEDF) as a therapeutic target in cardiovascular disease
- (2009) Kathrin Rychli et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- The reduction in pigment epithelium-derived factor is a sign of malignancy in ovarian cancer expressing low-level of vascular endothelial growth factor
- (2009) Takehiko Tsuchiya et al. GYNECOLOGICAL ENDOCRINOLOGY
- Laminin Receptor Involvement in the Anti-angiogenic Activity of Pigment Epithelium-derived Factor
- (2009) Adrien Bernard et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nuclear Receptor Co-repressor Is Required to Maintain Proliferation of Normal Intestinal Epithelial Cells in Culture and Down-modulates the Expression of Pigment Epithelium-derived Factor
- (2009) Geneviève Doyon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterization of PEDF: A multi-functional serpin family protein
- (2009) S. Filleur et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Progenitor cell trafficking in the vascular wall
- (2009) M. HRISTOV et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Analyses of Resected Human Brain Metastases of Breast Cancer Reveal the Association between Up-Regulation of Hexokinase 2 and Poor Prognosis
- (2009) D. Palmieri et al. MOLECULAR CANCER RESEARCH
- Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone
- (2009) Celia Andreu-Agulló et al. NATURE NEUROSCIENCE
- ‘Loss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanoma’
- (2009) J L Orgaz et al. ONCOGENE
- Different Expression of Vascular Endothelial Growth Factor and Pigment Epithelium-Derived Factor between Diabetic and Non-Diabetic Epiretinal Membranes
- (2009) Dong Heun Nam et al. OPHTHALMOLOGICA
- Cancer cell apoptotic pathways mediated by PEDF: prospects for therapy
- (2009) Matthew L. Broadhead et al. TRENDS IN MOLECULAR MEDICINE
- RETRACTED: Pigment epithelium-derived factor inhibits vascular endothelial growth factor-and interleukin-1beta-induced vascular permeability and angiogenesis in retinal endothelial cells
- (2009) Sardarpasha Sheikpranbabu et al. VASCULAR PHARMACOLOGY
- Cytosolic phospholipase A2-α is an early apoptotic activator in PEDF-induced endothelial cell apoptosis
- (2008) Tsung-Chuan Ho et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Modulation of VEGF signalling output by the Notch pathway
- (2008) Arndt F. Siekmann et al. BIOESSAYS
- Pigment Epithelium-Derived Factor (PEDF): Its Potential Therapeutic Implication in Diabetic Vascular Complications
- (2008) Sho-ichi Yamagishi et al. CURRENT DRUG TARGETS
- miR-126 Regulates Angiogenic Signaling and Vascular Integrity
- (2008) Jason E. Fish et al. DEVELOPMENTAL CELL
- The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis
- (2008) Shusheng Wang et al. DEVELOPMENTAL CELL
- Serum levels of pigment epithelium-derived factor (PEDF) are positively associated with visceral adiposity in Japanese patients with type 2 diabetes
- (2008) Kazuo Nakamura et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- PEDF-deficient mice exhibit an enhanced rate of retinal vascular expansion and are more sensitive to hyperoxia-mediated vessel obliteration
- (2008) Qiong Huang et al. EXPERIMENTAL EYE RESEARCH
- A comparison of epithelial and neural properties in progenitor cells derived from the adult human ciliary body and brain
- (2008) Morten C. Moe et al. EXPERIMENTAL EYE RESEARCH
- Pigment Epithelium-derived Factor (PEDF) Ameliorates Advanced Glycation End Product (AGE)-induced Hepatic Insulin Resistance In Vitro by Suppressing Rac-1 Activation
- (2008) T. Yoshida et al. HORMONE AND METABOLIC RESEARCH
- p73 isoforms affect VEGF, VEGF165b and PEDF expression in human colorectal tumors: VEGF165b downregulation as a marker of poor prognosis
- (2008) Raquel Díaz et al. INTERNATIONAL JOURNAL OF CANCER
- Serum levels of pigment epithelium-derived factor (PEDF) are an independent determinant of insulin resistance in patients with essential hypertension
- (2008) Kazuo Nakamura et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL)
- (2008) Chuhan Chung et al. JOURNAL OF HEPATOLOGY
- Pigment Epithelium-Derived Factor and Interleukin-6 Control Prostate Neuroendocrine Differentiation via Feed-Forward Mechanism
- (2008) Norm D. Smith et al. JOURNAL OF UROLOGY
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