Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells

Pigment epithelium-derived factor suppresses adipogenesis via inhibition of the MAPK/ERK pathway in 3T3-L1 preadipocytes

(2009) Min Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity

(2009) Seamus Crowe et al.   Cell Metabolism

Chemerin Is a Novel Adipocyte-Derived Factor Inducing Insulin Resistance in Primary Human Skeletal Muscle Cells

(2009) Henrike Sell et al.   DIABETES

Pigment epithelium-derived factor (PEDF) as a therapeutic target in cardiovascular disease

(2009) Kathrin Rychli et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Laminin Receptor Involvement in the Anti-angiogenic Activity of Pigment Epithelium-derived Factor

(2009) Adrien Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The anti-angiogenic factor PEDF is present in the human heart and is regulated by anoxia in cardiac myocytes and fibroblasts

(2009) Kathrin Rychli et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Characterization of PEDF: A multi-functional serpin family protein

(2009) S. Filleur et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Skeletal muscle insulin resistance induced by adipocyte-conditioned medium: underlying mechanisms and reversibility

(2008) Henrike Sell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The 67 kDa laminin receptor: structure, function and role in disease

(2008) John Nelson et al.   BIOSCIENCE REPORTS

Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation

(2008) Chiara Chiellini et al.   BMC MOLECULAR BIOLOGY

Reduced Adipose Tissue Oxygenation in Human Obesity: Evidence for Rarefaction, Macrophage Chemotaxis, and Inflammation Without an Angiogenic Response

(2008) M. Pasarica et al.   DIABETES

Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients

(2008) Alicia Jenkins et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL)

(2008) Chuhan Chung et al.   JOURNAL OF HEPATOLOGY

Pigment epithelium-derived factor induces THP-1 macrophage apoptosis and necrosis by the induction of the peroxisome proliferator-activated receptor gamma

(2007) Tsung-Chuan Ho et al.   MOLECULAR IMMUNOLOGY