标题
Aging biology: a new frontier for drug discovery
作者
关键词
-
出版物
Expert Opinion on Drug Discovery
Volume 7, Issue 3, Pages 217-229
出版商
Informa Healthcare
发表日期
2012-02-11
DOI
10.1517/17460441.2012.660144
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Characterization of Amyloid-β Granules in the Hippocampus of SAMP8 Mice
- (2018) Gemma Manich et al. JOURNAL OF ALZHEIMERS DISEASE
- The Canine (Dog) Model of Human Aging and Disease: Dietary, Environmental and Immunotherapy Approaches
- (2017) Carl W. Cotman et al. JOURNAL OF ALZHEIMERS DISEASE
- From Aging to Alzheimer's Disease: Unveiling “The Switch” with the Senescence-Accelerated Mouse Model (SAMP8)
- (2017) Merce Pallas et al. JOURNAL OF ALZHEIMERS DISEASE
- Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol
- (2016) Eugenia Morselli et al. Aging-US
- Metformin for aging and cancer prevention
- (2016) Vladimir N. Anisimov Aging-US
- Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection
- (2016) Ara B. Hwang et al. Aging-US
- Longevity and stress in Caenorhabditis elegans
- (2016) Katherine I. Zhou et al. Aging-US
- Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis
- (2011) Pablo J Fernandez-Marcos et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Sensing of energy and nutrients by AMP-activated protein kinase
- (2011) D Grahame Hardie AMERICAN JOURNAL OF CLINICAL NUTRITION
- Comparative Genetics and Genomics of Nematodes: Genome Structure, Development, and Lifestyle
- (2011) Ralf J. Sommer et al. Annual Review of Genetics
- Interplay between FOXO, TOR, and Akt
- (2011) Nissim Hay BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- FoxO transcription factors; Regulation by AKT and 14-3-3 proteins
- (2011) Guri Tzivion et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Autophagy and Aging
- (2011) David C. Rubinsztein et al. CELL
- Metformin slows down aging and extends life span of female SHR mice
- (2011) Vladimir N. Anisimov et al. CELL CYCLE
- TOR-driven aging: Speeding car without brakes
- (2011) Mikhail V Blagosklonny CELL CYCLE
- Cellular stress response pathways and ageing: intricate molecular relationships
- (2011) Nikos Kourtis et al. EMBO JOURNAL
- Mitochondria, reactive oxygen species, and chronological aging: A message from yeast
- (2011) Yong Pan EXPERIMENTAL GERONTOLOGY
- Extending life span by increasing oxidative stress
- (2011) Michael Ristow et al. FREE RADICAL BIOLOGY AND MEDICINE
- Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
- (2011) Camilla Burnett et al. NATURE
- Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates
- (2011) Timothy J. Collier et al. NATURE REVIEWS NEUROSCIENCE
- Cognitive Performances Are Selectively Enhanced during Chronic Caloric Restriction or Resveratrol Supplementation in a Primate
- (2011) Alexandre Dal-Pan et al. PLoS One
- Metformin As a Geroprotector
- (2011) Sven Bulterijs REJUVENATION RESEARCH
- Rapamycin As an Antiaging Therapeutic?: Targeting Mammalian Target of Rapamycin to Treat Hutchinson–Gilford Progeria and Neurodegenerative Diseases
- (2011) Andrew R. Mendelsohn et al. REJUVENATION RESEARCH
- Mitochondrial protein quality control during biogenesis and aging
- (2011) Brooke M. Baker et al. TRENDS IN BIOCHEMICAL SCIENCES
- Obesity and nutrient sensing TOR pathway in flies and vertebrates: Functional conservation of genetic mechanisms
- (2011) Sean Oldham TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Klotho and the Aging Process
- (2011) Makoto Kuro-o KOREAN JOURNAL OF INTERNAL MEDICINE
- Neurobiology of the aging dog
- (2010) Elizabeth Head AGE
- Connecting serum IGF-1, body size, and age in the domestic dog
- (2010) Kimberly A. Greer et al. AGE
- Genetic variation in insulin/IGF-1 signaling pathways and longevity
- (2010) Elad Ziv et al. AGEING RESEARCH REVIEWS
- Some highlights of research on aging with invertebrates, 2010
- (2010) Linda Partridge AGING CELL
- At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathways
- (2010) Gian Paolo Fadini et al. AGING CELL
- A pathway that links reproductive status to lifespan in Caenorhabditis elegans
- (2010) Cynthia Kenyon Annals of the New York Academy of Sciences
- Attention, executive functioning and memory in normal aged rhesus monkeys
- (2010) Alyson Zeamer et al. BEHAVIOURAL BRAIN RESEARCH
- Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging
- (2010) Laurent Mouchiroud et al. BIOFACTORS
- Insulin and aging
- (2010) Andrzej Bartke CELL CYCLE
- Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program
- (2010) Mikhail V Blagosklonny CELL CYCLE
- Aging and TOR: interwoven in the fabric of life
- (2010) Zelton Dave Sharp CELLULAR AND MOLECULAR LIFE SCIENCES
- Cardiac Oxidative Stress and Inflammation are Similar in SAMP8 and SAMR1 Mice and Unaltered by Curcumin and Ginkgo biloba Extract Intake
- (2010) Christina Schiborr et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Bacteria, yeast, worms, and flies: Exploiting simple model organisms to investigate human mitochondrial diseases
- (2010) Shane L. Rea et al. Developmental Disabilities Research Reviews
- Growth hormone, insulin and aging: The benefits of endocrine defects
- (2010) Andrzej Bartke EXPERIMENTAL GERONTOLOGY
- Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network
- (2010) Linda Partridge et al. EXPERIMENTAL GERONTOLOGY
- Role of TOR signaling in aging and related biological processes in Drosophila melanogaster
- (2010) Subhash D. Katewa et al. EXPERIMENTAL GERONTOLOGY
- Drosophila as a model to study cardiac aging
- (2010) Mayuko Nishimura et al. EXPERIMENTAL GERONTOLOGY
- Klotho protein deficiency and aging
- (2010) Hiroshi Manya et al. Geriatrics & Gerontology International
- AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism
- (2010) Valérie Vingtdeux et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
- (2010) Michelle Pacholec et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Longevity and aging in insects: Is reproduction costly; cheap; beneficial or irrelevant? A critical evaluation of the “trade-off” concept
- (2010) Arnold De Loof JOURNAL OF INSECT PHYSIOLOGY
- Metformin Supplementation and Life Span in Fischer-344 Rats
- (2010) D. L. Smith et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
- (2010) Richard A. Miller et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Can autophagy promote longevity?
- (2010) Frank Madeo et al. NATURE CELL BIOLOGY
- TOR and ageing: a complex pathway for a complex process
- (2010) M. A. McCormick et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity
- (2010) A. Mesquita et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Extending Healthy Life Span--From Yeast to Humans
- (2010) L. Fontana et al. SCIENCE
- LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
- (2009) R. J. Shaw Acta Physiologica
- Effects of dietary restriction on mortality and age-related phenotypes in the short-lived fishNothobranchius furzeri
- (2009) Eva Terzibasi et al. AGING CELL
- Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
- (2009) Ludmila Pawlikowska et al. AGING CELL
- Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
- (2009) Jesse J Smith et al. BMC Systems Biology
- Insulin/IGF-1 paradox of aging: Regulation via AKT/IKK/NF-κB signaling
- (2009) Antero Salminen et al. CELLULAR SIGNALLING
- Effects of Caloric Restriction on Cardiovascular Aging in Non-human Primates and Humans
- (2009) Christina Cruzen et al. CLINICS IN GERIATRIC MEDICINE
- Synthetic drugs with anti-ageing effects
- (2009) Vijay K. Kapoor et al. DRUG DISCOVERY TODAY
- Calorie Restriction and Dwarf Mice in Gerontological Research
- (2009) J. McKee Alderman et al. GERONTOLOGY
- Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations
- (2009) Yang Li et al. HUMAN MOLECULAR GENETICS
- Ageing, Immunosenescence and Inflammageing in the Dog and Cat
- (2009) M.J. Day JOURNAL OF COMPARATIVE PATHOLOGY
- Reduction of Calbindin D-28k-Immunoreactive Neurons in the Dog Dentate Gyrus
- (2009) Jung Hoon CHOI et al. JOURNAL OF VETERINARY MEDICAL SCIENCE
- Systematic gene expression profile of hypothalamus in calorie-restricted mice implicates the involvement of mTOR signaling in neuroprotective activity
- (2009) Pu Wu et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Recent progress in the biology and physiology of sirtuins
- (2009) Toren Finkel et al. NATURE
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- Induction of autophagy by spermidine promotes longevity
- (2009) Tobias Eisenberg et al. NATURE CELL BIOLOGY
- Senescence-Accelerated Mouse (SAM) with Special References to Neurodegeneration Models, SAMP8 and SAMP10 Mice
- (2009) Toshio Takeda NEUROCHEMICAL RESEARCH
- The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans
- (2009) Yi Zhang et al. PLoS One
- Association ofFOXO3Avariation with human longevity confirmed in German centenarians
- (2009) Friederike Flachsbart et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Association of the FOXO3A Locus with Extreme Longevity in a Southern Italian Centenarian Study
- (2009) Chiara Viviani Anselmi et al. REJUVENATION RESEARCH
- Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
- (2009) R. J. Colman et al. SCIENCE
- Interaction of estrogen receptors with insulin-like growth factor-I and Wnt signaling in the nervous system
- (2009) Olga Varea et al. STEROIDS
- Caloric restriction, SIRT1 and longevity
- (2009) Carles Cantó et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Regulation of the aging process by autophagy
- (2009) Antero Salminen et al. TRENDS IN MOLECULAR MEDICINE
- Design of aging intervention studies: the NIA interventions testing program
- (2008) N. L. Nadon et al. AGE
- Current understanding of klotho
- (2008) Yuhong Wang et al. AGEING RESEARCH REVIEWS
- Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
- (2008) Randy Strong et al. AGING CELL
- Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
- (2008) Leonard Guarente CELL
- Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model
- (2008) Javier Gutierrez-Cuesta et al. JOURNAL OF PINEAL RESEARCH
- APOE-related mortality: Effect of dementia, cardiovascular disease and gender
- (2008) Lina Rosvall et al. NEUROBIOLOGY OF AGING
- Region specific neuron loss in the aged canine hippocampus is reduced by enrichment
- (2006) Christina T. Siwak-Tapp et al. NEUROBIOLOGY OF AGING
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