TOR and ageing: a complex pathway for a complex process

Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density

(2016) Yong Pan et al.   Aging-US

Aging: Dial M for Mitochondria

(2016) Jae H. Hur et al.   Aging-US

Autophagy is required for extension of yeast chronological life span by rapamycin

(2014) Ashley L. Alvers et al.   Autophagy

The hypoxic response and aging

(2011) Matt Kaeberlein et al.   CELL CYCLE

RAG GTPases in nutrient-mediated TOR signaling pathway

(2011) Eunjung Kim et al.   CELL CYCLE

A Method for High-Throughput Quantitative Analysis of Yeast Chronological Life Span

(2011) C. J. Murakami et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans

(2010) Tsui-Ting Ching et al.   AGING CELL

A molecular mechanism of chronological aging in yeast

(2010) Christopher R. Burtner et al.   CELL CYCLE

Not all substrates are treated equally: Implications for mTOR, rapamycin-resistance, and cancer therapy

(2010) Andrew Y. Choo et al.   CELL CYCLE

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Autophagy in cellular growth control

(2010) Richard C. Wang et al.   FEBS LETTERS

FOXO3a Regulates Glycolysis via Transcriptional Control of Tumor Suppressor TSC1

(2010) Shikha Khatri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Dynamic Switch of Negative Feedback Regulation in Drosophila Akt–TOR Signaling

(2010) Lutz Kockel et al.   PLoS Genetics

The coordination of nuclear and mitochondrial communication during aging and calorie restriction

(2009) Lydia W.S. Finley et al.   AGEING RESEARCH REVIEWS

Autophagy and amino acid homeostasis are required for chronological longevity inSaccharomyces cerevisiae

(2009) Ashley L. Alvers et al.   AGING CELL

d4eBPacts downstream of both dTOR and dFoxo to modulate cardiac functional aging inDrosophila

(2009) Robert Wessells et al.   AGING CELL

The TOR pathway comes of age

(2009) Monique N. Stanfel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

mTOR and the control of whole body metabolism

(2009) Pazit Polak et al.   CURRENT OPINION IN CELL BIOLOGY

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

(2009) A. A. Soukas et al.   GENES & DEVELOPMENT

Deleting the 14-3-3 Protein Bmh1 Extends Life Span in Saccharomyces cerevisiae by Increasing Stress Response

(2009) Chen Wang et al.   GENETICS

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy

(2009) Y. Kamada et al.   MOLECULAR AND CELLULAR BIOLOGY

The Vam6 GEF Controls TORC1 by Activating the EGO Complex

(2009) Matteo Binda et al.   MOLECULAR CELL

Sfp1 Interaction with TORC1 and Mrs6 Reveals Feedback Regulation on TOR Signaling

(2009) Harri Lempiäinen et al.   MOLECULAR CELL

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

(2009) Luke S Tain et al.   NATURE NEUROSCIENCE

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans

(2009) Yi Zhang et al.   PLoS One

Direct control of mitochondrial function by mTOR

(2009) Arvind Ramanathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans

(2009) R. Mehta et al.   SCIENCE

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Nutrient control of TORC1, a cell-cycle regulator

(2009) Xuemin Wang et al.   TRENDS IN CELL BIOLOGY

Rictor/TORC2 Regulates Caenorhabditis elegans Fat Storage, Body Size, and Development through sgk-1

(2009) Kevin T Jones et al.   PLOS BIOLOGY

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

(2009) Di Chen et al.   PLoS Genetics

Impact of reduced insulin-like growth factor-1/insulin signaling on aging in mammals: novel findings

(2008) Andrzej Bartke   AGING CELL

Dietary composition specifies consumption, obesity, and lifespan inDrosophila melanogaster

(2008) Danielle A. Skorupa et al.   AGING CELL

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

(2008) Kristan K. Steffen et al.   CELL

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Diet and Aging

(2008) Matthew D.W. Piper et al.   Cell Metabolism

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Increased Respiration in thesch9ΔMutant Is Required for Increasing Chronological Life Span but Not Replicative Life Span

(2008) Hugo Lavoie et al.   EUKARYOTIC CELL

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species

(2008) E. D. Smith et al.   GENOME RESEARCH

An RNA Interference Screen Identifies a Novel Regulator of Target of Rapamycin That Mediates Hypoxia Suppression of Translation in Drosophila S2 Cells

(2008) Soo-Jung Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

(2008) Sakiko Honjoh et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9

(2008) Min Wei et al.   PLoS Genetics

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

Caloric Restriction and Aging: Studies in Mice and Monkeys

(2008) Rozalyn M. Anderson et al.   TOXICOLOGIC PATHOLOGY

Autophagy and aging: keeping that old broom working

(2008) Ana Maria Cuervo   TRENDS IN GENETICS