Designing prodrugs for the treatment of Parkinson's disease

Shuttle-Mediated Drug Delivery to the Brain

(2011) Morteza Malakoutikhah et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

L-Dopa Prodrugs: An Overview of Trends for Improving Parkinsons Disease Treatment

(2011) Antonio Di Stefano et al.   CURRENT PHARMACEUTICAL DESIGN

Prodrugs and Endogenous Transporters: Are They Suitable Tools for Drug Targeting into the Central Nervous System?

(2011) Barbara Pavan et al.   CURRENT PHARMACEUTICAL DESIGN

Enhancement of transdermal apomorphine delivery with a diester prodrug strategy

(2011) Kuo-Sheng Liu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

CNS delivery of l-dopa by a new hybrid glutathione–methionine peptidomimetic prodrug

(2010) Francesco Pinnen et al.   AMINO ACIDS

When Does Parkinson Disease Start?

(2010) Rodolfo Savica et al.   ARCHIVES OF NEUROLOGY

Design, synthesis, and preliminary pharmacological evaluation of new imidazolinones as l-DOPA prodrugs

(2010) Gianfabio Giorgioni et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor

(2010) Jarkko Rautio et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and biological evaluation of l-dopa amide derivatives as potential prodrugs for the treatment of Parkinson’s disease

(2010) Tao Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N-Acetyl-L-Methionyl-L-Dopa-Methyl Ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity

(2010) Alba Minelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Simultaneous determination of l-dopa and its prodrug (S)-4-(2-acetamido-3-ethoxy-3-oxopropyl)-1,2-phenylene diacetate in rat plasma by high-performance liquid chromatography–tandem mass spectrometry and its application in a pharmacokinetic study

(2010) Weizhe Jiang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Oral Apomorphine Delivery from Solid Lipid Nanoparticles with Different Monostearate Emulsifiers: Pharmacokinetic and Behavioral Evaluations

(2010) Ming-Jun Tsai et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis of dopamine and l-DOPA-α-glycosides by reaction with cyclomaltohexaose catalyzed by cyclomaltodextrin glucanyltransferase

(2009) Seung-Heon Yoon et al.   CARBOHYDRATE RESEARCH

Current Prodrug Design for Drug Discovery

(2009) Pei-Wen Hsieh et al.   CURRENT PHARMACEUTICAL DESIGN

Recent Advances in Medicinal Chemistry and Pharmaceutical Technology- Strategies for Drug Delivery to the Brain

(2009) Nunzio Denora et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

New drug delivery strategies for improved Parkinson's disease therapy

(2009) Antonio Di Stefano et al.   Expert Opinion on Drug Delivery

Glucose Promoiety Enables Glucose Transporter Mediated Brain Uptake of Ketoprofen and Indomethacin Prodrugs in Rats

(2009) Mikko Gynther et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prodrug Approaches for CNS Delivery

(2008) Jarkko Rautio et al.   AAPS Journal

Design, Synthesis and Biological Evaluation of Glutathione Peptidomimetics as Components of Anti-Parkinson Prodrugs

(2008) Swati S. More et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Codrugs Linkingl-Dopa and Sulfur-Containing Antioxidants: New Pharmacological Tools against Parkinson’s Disease

(2008) Francesco Pinnen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Progress in Drug Delivery to the Central Nervous System by the Prodrug Approach

(2008) Barbara Pavan et al.   MOLECULES

Galactosylated dopamine enters into the brain, blocks the mesocorticolimbic system and modulates activity and scanning time in Naples high excitability rats

(2007) L.A. Ruocco et al.   NEUROSCIENCE