期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 52, 期 2, 页码 559-563出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm801266x
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A series of multifunctional codrugs (1-6) were synthesized to overcome the pro-oxidant effect associated with L-dopa (LD) therapy. Target compounds release LD and dopamine (DA) in human plasma after enzymatic hydrolysis, displaying an antioxidant effect superior to that of N-acetylcysteine (NAC). After intracerebroventricular injection of codrug 4, the levels of DA in the striatum were higher than those in LD-treated groups, indicating that this compound has a longer half-life in brain than LD.
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