Article
Pharmacology & Pharmacy
Sara M. Talaat, Yosra S. R. Elnaggar, Samar O. El-Ganainy, Mennatallah A. Gowayed, Maram Allam, Ossama Y. Abdallah
Summary: Fisetin (FIS) has been extensively studied as a potent anticancer agent for various types of cancers, including breast cancer. However, its poor aqueous solubility limits its clinical application. This study aimed to develop FIS phytosomes (FIS-PHY) to improve its physicochemical properties and enhance its anticancer activity.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Alaa R. Aboushanab, Riham M. El-Moslemany, Amal H. El-Kamel, Radwa A. Mehanna, Basant A. Bakr, Asmaa A. Ashour
Summary: This study developed lactoferrin-coated fisetin-loaded beta-cyclodextrin nanosponges (LF-FS-NS) for targeted delivery of fisetin to breast cancer. LF-FS-NS showed good colloidal properties, high loading efficiency, and sustained drug release. It significantly improved the oral and IP bioavailability of fisetin and demonstrated higher antitumor efficacy compared to the free drug and uncoated formulation.
Article
Biochemistry & Molecular Biology
Mohd. Afzal, Abdullah Alarifi, Abdalnaser Mahmoud Karami, Rashid Ayub, Naaser A. Y. Abduh, Waseem Sharaf Saeed, Mohd. Muddassir
Summary: In this study, the synergistic therapeutic effects of naturally occurring flavonoids kaempferol (K) and fisetin (F) on triple-negative breast cancer (TNBC) were investigated. The combination of K and F showed higher cytotoxicity and inhibitory effect on cell viability in TNBC cells compared to the individual compounds. Morphological changes associated with apoptotic cell death further supported the synergistic association between K and F. The study also evaluated the cell death pathway induced by the combinational treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Khalid Imtiyaz, Arshad Husain Rahmani, Mohammed A. Alsahli, Saleh A. Almatroodi, M. Moshahid Alam Rizvi
Summary: Fisetin is found to have anticancer properties against skin cancer cells by inhibiting MTH1, upregulating ATM and P53, and inducing cell apoptosis.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Pharmacology & Pharmacy
Antonio Lipa Castro, Sebastien Pomel, Catherine Cailleau, Natalie Fournier, Indira Dennemont, Philippe M. Loiseau, Gillian Barratt
Summary: This article describes the in-vivo evaluation of AmB-loaded, lipid-based cochleate systems designed for the oral route. The study found that cochleate formulations based on Lipoid PSP70 show promising antiparasitic activity for the treatment of visceral leishmaniasis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Oncology
Shayan Khozooei, Konstanze Lettau, Francesca Barletta, Tina Jost, Simone Rebholz, Soundaram Veerappan, Mirita Franz-Wachtel, Boris Macek, George Iliakis, Luitpold Distel, Daniel Zips, Mahmoud Toulany
Summary: Fisetin induces double-strand breaks (DSB) similar to ionizing radiation (IR) and impairs repair of IR-induced DSB by suppressing the classical non-homologous end-joining and homologous recombination repair pathways. Fisetin inhibits DDR signaling and sensitizes TNBC cells to radiotherapy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Engineering, Chemical
Meena Tilawat, Smita Bonde
Summary: In this research, quercetin-loaded nanocochleates were successfully developed using liposomes as a precursor. The optimized formulation showed favorable particle size, encapsulation efficiency, and drug release. This novel approach can serve as a better therapeutic option for quercetin.
PARTICULATE SCIENCE AND TECHNOLOGY
(2023)
Article
Cell Biology
Robert Kubina, Kamil Krzykawski, Arkadiusz Dziedzic, Agata Kabala-Dzik
Summary: Although standard cancer treatment strategies are relatively effective, head and neck cancer (HNC) remains one of the leading causes of morbidity and mortality. Kaempferol and fisetin, two bioactive compounds of plant origin, have shown potential as anti-cancer agents against HNC cells by inhibiting proliferation, reducing cell migration, and inducing apoptosis. These effects are mediated through the regulation of cell cycle and activation of caspase-3.
Article
Biochemistry & Molecular Biology
Nazia Afroze, Sreepoorna Pramodh, Jasmin Shafarin, Khuloud Bajbouj, Mawieh Hamad, Madhumitha Kedhari Sundaram, Shafiul Haque, Arif Hussain
Summary: Fisetin inhibits cell proliferation, promotes apoptosis, and improves oxidative stress and inflammation through regulating various signaling pathways, suggesting its potential therapeutic value in cancer management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Instruments & Instrumentation
Sara M. Talaat, Yosra S. R. Elnaggar, Mennatallah A. Gowayed, Samar O. El-Ganainy, Maram Allam, Ossama Y. Abdallah
Summary: In this study, a novel biocompatible phytosomal system, cholephytosomes, was formed by complexing fisetin with soy phosphatidylcholine in the presence of cholesterol. Modified vesicles, mPHY and HPHY, showed promising physicochemical properties and significantly improved the antitumor activity against breast cancer cells. These findings suggest that tailoring novel phytosomal nanosystems for fisetin could be a potential approach for its clinical utility against cancer.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Benjaporn Buranrat, Mutita Junking
Summary: Fisetin exerts inhibitory effects on human breast and cervical cancer cells, reducing cell growth, activating apoptosis, and suppressing cell migration. The results suggest that fisetin may be a potential anticancer agent for the treatment of breast and cervical cancers in humans.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Lu Zhang, Wenmin Chen, Suling Liu, Ceshi Chen
Summary: The potential roles of breast cancer stem cells (BCSCs) in tumor initiation and recurrence have been recognized for many decades. Due to their strong capacity for self-renewal and differentiation, BCSCs are the major reasons for poor clinical outcomes and low therapeutic response. Several hypotheses on the origin of cancer stem cells have been proposed, including critical gene mutations in stem cells, dedifferentiation of somatic cells, and cell plasticity remodeling by epithelial-mesenchymal transition (EMT) and the tumor microenvironment. Moreover, the tumor microenvironment, including cellular components and cytokines, modulates the self-renewal and therapeutic resistance of BCSCs. Small molecules, antibodies, and chimeric antigen receptor (CAR)-T cells targeting BCSCs have been developed, and their applications in combination with conventional therapies are undergoing clinical trials. In this review, we focus on the features of BCSCs, emphasize the major factors and tumor environment that regulate the stemness of BCSCs, and discuss potential BCSC-targeting therapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Chemistry, Medicinal
Rachna M. Kumar, Hitesh Kumar, Tanvi Bhatt, Rupshee Jain, Kanan Panchal, Akash Chaurasiya, Vikas Jain
Summary: Cancer is a leading cause of death worldwide. Fisetin, a naturally derived flavone, has been found to have antioxidant, anti-inflammatory, antiangiogenic, and anticancer properties. However, its poor bioavailability limits its clinical use. Nanomedicine approaches, such as formulating fisetin into lipid or polymer-based systems, can address the issue of fisetin delivery.
Article
Biochemistry & Molecular Biology
Balak Das Kurmi, Shivani Rai Paliwal
Summary: This study reports the development of a doxorubicin-loaded liposomal system coated with alpha-tocopherol polyethylene glycol 1000 succinate through a quality by design approach, showing promising anticancer and hemocompatibility potential. Optimization of formulation variables using systematic design of experiments resulted in nano-sized vesicles with favorable development parameters, and the inclusion of TPGS significantly improved the quality attributes of the liposomal formulations. The study concludes that quality by design optimization can be effectively utilized for obtaining liposomal formulations with desired attributes, and TPGS-coated liposomes may serve as an effective anticancer drug delivery vehicle.
JOURNAL OF LIPOSOME RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Minna Lehtisalo, E. Katriina Tarkiainen, Mikko Neuvonen, Mikko Holmberg, Johanna I. Kiiski, Outi Lapatto-Reiniluoto, Anne M. Filppula, Mika Kurkela, Janne T. Backman, Mikko Niemi
Summary: Ticagrelor increases the plasma concentration of rosuvastatin in humans, most likely by inhibiting intestinal BCRP. Therefore, concurrent use of ticagrelor and high doses of rosuvastatin should be avoided.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
C. Bothiraja, Vijay Kumbhar, Atmaram Pawar, Karimunnisa Shaikh, Ravindra Kamble
Article
Education, Scientific Disciplines
Nikita Maruti Gaikwad, Karimunnisa Sameer Shaikh, Pravin Digambar Chaudhari
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2017)
Article
Education, Scientific Disciplines
Shaikh Karimunnisa, Pandhe Puja, Kale Sangita, Bothiraja Chellampillai
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2018)
Article
Biotechnology & Applied Microbiology
Atmaram Pawar, Srishti Singh, S. Rajalakshmi, Karimunnisa Shaikh, C. Bothiraja
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2018)
Article
Pharmacology & Pharmacy
Siddhodhan S. Bodade, Karimunnisa Sameer Shaikh, Meghana S. Kamble, Praveen D. Chaudhari
Article
Pharmacology & Pharmacy
Amol D. Thingale, Karimunnisa S. Shaikh, Prajakta R. Channekar, Upendra C. Galgatte, Praveen D. Chaudhari, Chellampillai Bothiraja
Article
Chemistry, Medicinal
Shaikh Karimunnisa, Pawar Atmaram
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2013)
Article
Engineering, Mechanical
C. Bothiraja, Atmaram P. Pawar, Ashwin J. Mali, Karimunnisa S. Shaikh
INTERNATIONAL JOURNAL OF SURFACE SCIENCE AND ENGINEERING
(2013)
Article
Materials Science, Multidisciplinary
C. Bothiraja, U. H. Thorat, A. P. Pawar, K. S. Shaikh
MATERIALS TECHNOLOGY
(2014)
Article
Plant Sciences
Pavan Ram Kamble, Karimunnisa Sameer Shaikh
Summary: The study successfully improved the solubility and oral bioavailability of plumbagin through a self-nanoemulsifying drug delivery system, which optimized the liquid formulation and demonstrated enhanced performance compared to pure plumbagin, resulting in significantly higher bioavailability and intestinal permeability.
Review
Chemistry, Multidisciplinary
Atmaram Pawar, C. Bothiraja, Karimunnisa Shaikh, Ashwin Mali
Article
Pharmacology & Pharmacy
Chellampillai Bothiraja, Amol D. Gholap, Karimunnisa S. Shaikh, Atmaram P. Pawar
THERAPEUTIC DELIVERY
(2014)
Article
Pharmacology & Pharmacy
Pavan Ram Kamble, Karimunnisa Sameer Shaikh, Pravin Digambar Chaudhari
ADVANCED PHARMACEUTICAL BULLETIN
(2014)
Article
Pharmacology & Pharmacy
Chellampillai Bothiraja, Harshad S. Kapare, Atmaram P. Pawar, Karimunnisa S. Shaikh
THERAPEUTIC DELIVERY
(2013)