Article
Medicine, Research & Experimental
Sekaran Balaji, Usha Kim, Veerappan Muthukkaruppan, Ayyasamy Vanniarajan
Summary: The interactions between cancer and non-cancerous cells in the TME through exosomes play a significant role in influencing tumor progression, therapeutic resistance, and metastasis. Wnt signaling, which is often involved in exosomal transport, represents a potential therapeutic target in inhibiting these processes.
Review
Biochemistry & Molecular Biology
Ming-Yu Chou, Muh-Hwa Yang
Summary: The interplay between EMT and immune metabolic changes in cancer cells during tumor metastasis has gained interest among researchers. Understanding how they influence each other may provide novel explanations for immune surveillance during metastasis. Studying immunometabolism in the regulatory loop between tumor-infiltrating immune cells and EMT is crucial for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Qing Zhang, Jialin Wang, Junwen Zhang, Fusheng Liu
Summary: Mesenchymal stem cells (MSCs) play crucial roles in the tumor microenvironment (TME), contributing to tumor progression and therapeutic resistance. Glioma-resident MSCs (GR-MSCs) enhance the tumorigenicity of glioma stem cells (GSCs) through the IL-6/gp130/STAT3 pathway. Higher percentage of GR-MSCs in the TME leads to poor prognosis of glioma patients and their secretion of specific miRNA promotes tumor growth. Novel therapeutic strategies targeting GR-MSCs are urgently needed for GBM patients.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Immunology
Tiantian Wu, Caijin Tang, Renchuan Tao, Xiangzhi Yong, Qiaozhi Jiang, Cong Feng
Summary: The research found that PD-L1 is highly expressed in oral squamous cell carcinoma (OSCC), correlated with worse survival, and related to macrophage infiltration and EMT process. Patients with high PD-L1 expression may benefit from ICI treatment and show higher sensitivity to certain chemical drugs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jingnan Zhang, Ze Zhang, Zhenlin Huang, Manlin Li, Fan Yang, Zeqi Wu, Qian Guo, Xiyu Mei, Bin Lu, Changhong Wang, Zhengtao Wang, Lili Ji
Summary: This study reported that a natural compound isotoosendanin (ITSN) reduced TNBC metastasis by inhibiting TGF-P-induced EMT and the formation of invadopodia. ITSN can directly interact with TGF-P receptor type-1 (TGFPR1) and abrogated the kinase activity of TGFPR1, thereby blocking the TGF-P-initiated downstream signaling pathway. Moreover, ITSN also improved the inhibitory efficacy of programmed cell death 1 ligand 1 (PD-L1) antibody for TNBC in vivo via inhibiting the TGF-P-mediated EMT in the tumor microenvironment.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Cell Biology
Bo Xiao, Liyan Liu, Zhuoyuan Chen, Aoyu Li, Pingxiao Wang, Cheng Xiang, Yi Zeng, Hui Li, Tao Xiao
Summary: This study constructed an EMT-related lncRNA signature for melanoma patients by analyzing RNA expression data and clinical features, indicating that these lncRNAs can function as potential independent prognostic biomarkers for melanoma survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Youssef Slama, Franck Ah-Pine, Mohamed Khettab, Angelique Arcambal, Mickael Begue, Fabien Dutheil, Philippe Gasque
Summary: Mesenchymal stem/stromal cells (MSCs) play a dual role in cancer pathophysiology by interacting with the tumor microenvironment and influencing tumor cells. They can promote tumor progression through various mechanisms while also exhibiting therapeutic effects such as anti-tumor and anti-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Zhishang Meng, Yanzhu Chen, Wenyi Wu, Bin Yan, Lusi Zhang, Huihui Chen, Yongan Meng, Youling Liang, Xiaoxi Yao, Jing Luo
Summary: This study identified PRRX1 as a reliable TME-related biomarker that can predict survival and provide new insights into therapy for uveal melanoma (UM) patients. The results showed that increased PRRX1 expression is independently associated with poorer overall survival and metastasis-free survival in UM patients, and PRRX1 promotes malignant progression by facilitating epithelial-mesenchymal transition. These findings suggest that PRRX1 may be a potential target for UM therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Pinaki Banerjee, Prachi Kapse, Shehnaz Siddique, Moumita Kundu, Jasoda Choudhari, Varshasnata Mohanty, Diksha Malhotra, Suresh W. Gosavi, Rajesh N. Gacche, Gopal C. Kundu
Summary: Prostate cancer is a heterogeneous disease involving multiple cell types, with tumor heterogeneity resulting from genomic instability and sub-clone differentiation. Prostate cancer stem cells (PCSCs), a small subset of cells with tumor-initiating and stem-like properties, play crucial roles in disease progression, drug resistance, and relapse. This review discusses the origin, hierarchy, and plasticity of PCSCs, methods for their isolation and enrichment, as well as cellular and metabolic signaling pathways involved in their induction and maintenance, and potential therapeutic targeting.
CANCER BIOLOGY & MEDICINE
(2023)
Review
Cell & Tissue Engineering
Feng Ju, Manar M. Atyah, Nellie Horstmann, Sheraz Gul, Razi Vago, Christiane J. Bruns, Yue Zhao, Qiong-Zhu Dong, Ning Ren
Summary: This review summarizes the latest findings on the morphology, signaling pathways, and interactions of cancer stem cell (CSC) niches, as well as the genetic and epigenetic modulations involved in CSC maintenance. The crosstalk between CSCs and their niche plays a crucial role in therapy resistance and recurrence.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Xiaofang Chen, Ningyu Li, Jianyu Weng, Xin Du
Summary: Myelodysplastic syndrome (MDS) is a group of blood disorders related to dysfunction of hematopoietic stem and progenitor cells. Mesenchymal stem cells (MSCs) in the bone marrow microenvironment play a crucial role in normal hematopoiesis, but their aging and diminished regenerative capacities can contribute to disease progression. Recent studies have provided new insights into the role of MSCs in MDS, suggesting potential targets for treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Yuhe Huang, Weiqi Hong, Xiawei Wei
Summary: This review describes the molecular mechanisms, signaling pathways, and stages of tumorigenesis involved in the EMT process and discusses the role of EMT in tumor metastasis. It provides new insights and strategies for tumor therapy targeting EMT.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiuyuan Zhang, Yiming Li, Pengbo Hu, Liang Xu, Hong Qiu
Summary: In this study, the joint role of epithelial-mesenchymal transition (EMT) and the immune microenvironment in gastric cancer (GC) progression was investigated. A model called EIRG_score was developed to predict prognosis and immunotherapeutic response. The results showed that the EIRG_score was significantly associated with prognosis, immune infiltration, gene mutation, chemotherapeutic drug sensitivity, and immunotherapy response.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
JunJian He, WeiChao Hu, Qin Ouyang, ShengWei Zhang, LiJiao He, WeiYan Chen, XinZhe Li
Summary: This paper reviews the pathogenic mechanisms by which H. pylori induces gastric stem cell-like properties and CSCs, and supplements the existing Correa model. H. pylori infection leads to dysfunction of developmental signaling pathways and alteration of gastric mucosal microenvironment, potentially promoting gastric stem cell-like properties through epithelial-mesenchymal transition.
Review
Oncology
Lili Qiao, Yanfei Chen, Ning Liang, Jian Xie, Guodong Deng, Fangjie Chen, Xiaojuan Wang, Fengjun Liu, Yupeng Li, Jiandong Zhang
Summary: Radiotherapy plays a crucial role in cancer treatment, but its effectiveness is often limited by radioresistance. Epithelial-to-mesenchymal transition (EMT), a biological process that gives cancer cells invasive and metastatic properties, as well as radioresistance, has been found to be closely related. Understanding the relationship between EMT and radioresistance is important for improving the efficiency of radiotherapy.
FRONTIERS IN ONCOLOGY
(2022)
