Article
Nanoscience & Nanotechnology
Ting He, Jin He, Muhammad Rizwan Younis, Nicholas Thomas Blum, Shan Lei, Yinling Zhang, Peng Huang, Jing Lin
Summary: The study developed a pH/light dual-stimuli-responsive nanotheranostic agent for effective treatment of U87MG tumors in vivo, showing potential for application in multimodal imaging-guided synergistic therapy of cancer.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Hongwei Lu, Ji Xu, Jinfan Yang, Zhongling Wang, Peng Xu, Qian Hao, Wen Luo, Shuaijun Li, Zhengqing Li, Xiangdong Xue, Hongbo Zheng, Zhangjian Zhou, Hao Wu, Xiaobin Ma, Yuanpei Li
Summary: This study presents a smart on-demand targeting nanotheranostic system that improves drug delivery efficiency for ovarian cancer through stimuli-responsive releasing.
Article
Chemistry, Multidisciplinary
Zhe Dong, Peng Liang, Guoqiang Guan, Baoli Yin, Youjuan Wang, Renye Yue, Xiaobing Zhang, Guosheng Song
Summary: In this study, a novel nanoplatform was designed to enhance the effectiveness of ferroptosis-based cancer therapy. The nanoplatform successfully overcame the hypoxia-induced resistance of ferroptosis by providing oxygen supply and breaking down lipid droplets. The results showed that the nanoplatform induced higher levels of oxidative stress, lipid peroxidation, and GSH depletion, leading to effective inhibition of tumor growth. Furthermore, the release of manganese from the nanoplatform could be monitored using imaging techniques.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Inorganic & Nuclear
Han Zhou, Ming Qi, Jing Shao, Fengsheng Wang, Xiaoling Li, Zhiguo Zhou, Shiping Yang, Hong Yang
Summary: A pH- and GSH-responsive dual-mode MRI contrast agent was developed by incorporating MnOx into Zr-based MOF nanoparticles, showing enhanced signal in tumor micro-environment and potential for dual H-1/F-19 MRI imaging.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2021)
Article
Polymer Science
Mariusz Zalewski, Dawid Janasik, Anna Kapala, Masafumi Minoshima, Fuminori Sugihara, Wojciech Raj, Joanna Pietrasik, Kazuya Kikuchi, Tomasz Krawczyk
Summary: This work synthesized a series of copolymers based on TFEMA, HFiPMA, DMAEMA, or HEMA units, and found that copolymers containing 15-25 wt% TFEMA or 18-22 wt% HFiPMA exhibit the highest S/N values in F-19 NMR spectra. HFiPMA copolymers show strong pH sensitivity on T-1 and T-2 relaxation times, while TFEMA copolymers only significantly affect T-2 relaxation time.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2022)
Article
Materials Science, Multidisciplinary
Han Zhou, Ming Qi, Jing Shao, Xiaoling Li, Zhiguo Zhou, Shiping Yang, Hong Yang
Summary: A pH-sensitive 19F MRI contrast agent based on Zr-based MOF nanoparticles was developed, which could release organic ligands under acidic conditions to enhance the signal. This contrast agent successfully turned on the 19F MRI signal in acidic tumor micro-environments, providing an alternative strategy for designing responsive contrast agents.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Faiqa Nazir, Tanveer A. Tabish, Fatima Tariq, Shanza Iftikhar, Rijja Wasim, Gul Shahnaz
Summary: This review summarizes recent developments in stimuli-based targeted drug delivery systems for the site-specific release of antibiotics. By utilizing various stimuli, controlled and timely release of antibiotics at the site of infection can be achieved.
DRUG DISCOVERY TODAY
(2022)
Article
Nanoscience & Nanotechnology
Xingkun Luan, Zehong Xiang, Jiangtao Dong, Chen Wang, Xiaona Li, Qiang Shi, Xuezhong Du
Summary: A universal strategy for silane functionalization of metal-organic frameworks (MOFs) was developed, which involved the coupling of silanes with hydroxyl groups of MOFs to form metal-O-Si bonds. The strategy enabled the functionalization of MOFs with a wide variety of applications. Furthermore, the construction of supramolecular nanovalves on the surface of silanized MOFs demonstrated excellent controlled drug release and inhibitory effect on tumor growth.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Adil Usman, Cheng Zhang, Jiacheng Zhao, Hui Peng, Nyoman D. Kurniawan, Changkui Fu, David J. T. Hill, Andrew K. Whittaker
Summary: A series of terpolymers with thermoresponsive properties were synthesized, and it was found that above the LCST, the F-19 MRI imaging intensity decreased due to enhanced dipolar interactions of the F-19 spins. By incorporating a hydrophobic model drug through an acid cleavable hydrazone linkage, a thermo- and pH-responsive F-19 MRI agent was designed.
Review
Engineering, Environmental
Zahra Mazidi, Sanaz Javanmardi, Seyed Morteza Naghib, Zahra Mohammadpour
Summary: Despite significant advancements in tumor therapy, there is still a need for improvement due to the side effects and disease recurrence. Implantable biomaterials, with their unique characteristics, offer a promising solution for drug delivery systems, allowing for precise control over the release of therapeutic agents. This review article discusses the recent progress in stimuli-responsive implantable drug delivery systems for preventing tumor recurrence and suppressing tumors, as well as the preparation process, physicochemical characteristics, and drug release kinetics of these platforms.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Roya Sedghi, Somayeh Ashrafzadeh, Bahareh Heidari
Summary: A new pH responsive CUR imprinted polymer GO@CUR-MIP was synthesized and showed high adsorption capacity and selectivity for CUR, with controlled and sustained release in response to environmental pH changes. The pH responsiveness of the system led to targeted drug delivery potential, while the inclusion complex improved drug interaction with the nanocomposite. The novel system has potential in separation and drug delivery processes.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Polymer Science
Marcin Mackiewicz, Serife Dagdelen, Muhammad Sagir Abubakar, Jan Romanski, Ewelina Waleka-Bargiel, Marcin Karbarz
Summary: Novel hollow hydrogel capsules were synthesized using a precipitation polymerization method, making them stimuli-sensitive and degradable. The capsules were prepared by crosslinking N-isopropylacrylamide with -N,N'-bis(acryloyl)cystine on-C = C-modified sacrificial dimethyldie-thoxysilane emulsion templates, and the silica core was removed to form the capsules. The capsules showed stability and pH sensitivity due to the presence of carboxylic groups from the crosslinking agent. The polymer network of the capsules was susceptible to degradation by the reducing agent glutathione, which allowed for controlled release of the loaded anticancer drug Doxorubicin.
POLYMER DEGRADATION AND STABILITY
(2023)
Article
Materials Science, Biomaterials
Jie Yu, Xiaoli Zhang, Zhichao Pei, Qi Shuai
Summary: A synergistic phototherapy and hypoxia-activated chemotherapy nanoplatform based on melanin nanoparticles was developed, showing favorable photothermal conversion efficiency, desired cytocompatibility, and excellent synergistic therapeutic efficacy.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Applied
Hongying Su, Rong Zheng, Linrui Jiang, Ni Zeng, Kun Yu, Yunfei Zhi, Shaoyun Shan
Summary: Dextran hydrogels (Dex-SS) containing both disulfide and Schiff base bonds were developed using a facile method based on dextran oxidation and Schiff base linkages formation, showing strong cross-linking degree and pH/GSH-responsive release behavior.
CARBOHYDRATE POLYMERS
(2021)
Article
Nanoscience & Nanotechnology
Jana Kousalova, Milada Sirova, Libor Kostka, Vladimir Subr, Jirina Kovarova, Katerina Behalova, Martin Studenovsky, Marek Kovar, Tomas Etrych
Summary: This study describes the design, synthesis, physicochemical and biological characteristics of water-soluble copolymer conjugates bearing actinonin for advanced drug delivery and inhibition of metastatic spread. The developed nanosystems showed favorable drug release kinetics and effectively inhibited the metastatic spread of cancer cells, highlighting their potential clinical application.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zhibo Yu, Nicolas Tsapis, Francois Fay, Liang Chen, Andrii Karpus, Xiangyang Shi, Catherine Cailleau, Samuel Garcia Perez, Nicolas Huang, Juliette Vergnaud, Serge Mignani, Jean-Pierre Majoral, Elias Fattal
Summary: Small interfering RNA (siRNA) shows potential in treating rheumatoid arthritis by inhibiting major cytokines like tumor necrosis factor-alpha (TNF-alpha). Researchers have developed original cationic amphiphilic phosphorus dendrons that can form dendriplexes with TNF-alpha siRNA. These dendriplexes protect siRNA from degradation and enhance macrophage uptake, leading to significant inhibition of TNF-alpha expression and anti-inflammatory effects in in vitro and in vivo models. This opens up important perspectives for using these original amphiphilic dendrons in chronic inflammatory diseases.
Article
Pharmacology & Pharmacy
Mohamed Beladjine, Claire Albert, Maxime Sintes, Ghozlene Mekhloufi, Claire Gueutin, Valerie Nicolas, Alexis Canette, Michael Trichet, Nicolas Tsapis, Laurence Michel, Florence Agnely, Nicolas Huang
Summary: The innovative Pickering emulsions can co-encapsulate two active pharmaceutical ingredients for topical use. The emulsions are stable and biocompatible, with no negative effects on human keratinocytes. These emulsions show promise as a multidrug delivery system for chronic inflammatory skin diseases.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Kamila Bohne Japiassu, Francois Fay, Alessandro Marengo, Sebastiao A. Mendanha, Catherine Cailleau, Younes Louaguenouni, Qinglin Wang, Stephanie Denis, Nicolas Tsapis, Thais Leite Nascimento, Eliana Martins Lima, Elias Fattal
Summary: In this study, lipid nanoparticulate platforms loaded with dexamethasone were developed and evaluated. The dexamethasone-loaded liposomes, with sizes below 150 nm, were coated with polyethylene glycol, hyaluronic acid, or a mixture of both to cross the pulmonary mucus layer and target alveolar proinflammatory macrophages expressing CD44. In vitro experiments showed that encapsulated dexamethasone in liposomes, especially in HA-bearing ones, improved anti-inflammatory efficacy compared to the free drug. In vivo data demonstrated that dexamethasone-loaded liposomes exhibited improved consistency in efficacy compared to free dexamethasone.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Barbara Tessier, Nicolas Tsapis, Elias Fattal, Laurence Moine
Summary: Glucocorticoids (GC) are commonly used drugs for inflammatory diseases, but their prolonged use can lead to severe side effects. Recent advancements in GC prodrugs and conjugates, administered as free forms or nanoparticles, have improved drug delivery, controlled release, and targeting in inflammatory sites. This review highlights the potential of these novel strategies and discusses their design strategies and recent advances.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Saadat Hussain, Mujeeb Ur-Rehman, Aqsa Arif, Catherine Cailleau, Cynthia Gillet, Rudaba Saleem, Hira Noor, Farwa Naqvi, Almas Jabeen, M. Iqbal Atta-ur-Rahman, M. Iqbal Choudhary, Elias Fattal, Nicolas Tsapis
Summary: New lipidic prodrugs of diclofenac were synthesized by grafting aliphatic chains to diclofenac through an ester bond. The nanoparticles of the prodrugs were successfully formulated and exhibited good stability. The prodrug nanoparticles showed dose-dependent inhibition of TNF-α comparable to standard diclofenac sodium.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Baptiste Robin, Ludivine Mousnier, Hung Le, Nadege Grabowski, David Chapron, Ophelie Bellance-Mina, Nicolas Huang, Florence Agnely, Elias Fattal, Nicolas Tsapis
Summary: Most nanoparticles used for drug delivery are spherical, but elongated particles have advantages in cellular uptake. In this study, we synthesized biocompatible polylactide-b-poly(ethylene glycol) (PLA-PEG) polymers with carboxylate moieties and used them to form worm-like nanoparticles. By adjusting the molar mass of the PLA block, we obtained worm-like nanoparticles with varying aspect ratios. The proportion of worm-like particles increased as the molar mass of the PLA block decreased, contrary to the usual behavior of block polymers. These anisotropic nanoparticles showed increased cellular uptake compared to their spherical counterparts, highlighting their potential for drug delivery applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Mujeeb Ur-Rehman, Franceline Reynaud, Sinda Lepetre, Sonia Abreu, Pierre Chaminade, Elias Fattal, Nicolas Tsapis
Summary: In this study, lipid-drug conjugates (LDCs) of dexamethasone (DXM) with different lipid-drug linkages were synthesized and turned into nanoscale particles. The encapsulation efficacy of LDCs was above 95%, with good stability and no recrystallization observed. Ester and carbonate LDC nanoparticles exerted anti-inflammatory activity, while the carbamate LDC nanoparticles were toxic to macrophages and discarded. The release rate of DXM from ester particles was faster than that from carbonate particles, leading to a lower exposure to DXM from carbonate LDC nanoparticles in pharmacokinetics and biodistribution studies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Rheumatology
Audrey Paoletti, Bineta Ly, Catherine Cailleau, Fan Gao, Marie Pean de Ponfilly-Sotier, Juliette Pascaud, Elodie Riviere, Luxin Yang, Lilian Nwosu, Aziza Elmesmari, Franceline Reynaud, Magali Hita, David Paterson, Julien Reboud, Francois Fay, Gaetane Nocturne, Nicolas Tsapis, Iain B. Mcinnes, Mariola Kurowska-Stolarska, Elias Fattal, Xavier Mariette
Summary: This study demonstrated that the delivery of antagomiR-155-5p encapsulated in PEG liposomes to monocytes and macrophages effectively reduced joint inflammation in murine models of rheumatoid arthritis, suggesting a promising therapeutic strategy for human disease.
ARTHRITIS & RHEUMATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Geraldine Landon, Guillaume Phan, Francois Fay, Celine Bouvier-Capely, Elias Fattal
Summary: Decorporating treatment is crucial for internal contamination with radionuclides. The existing therapies often lack effectiveness, and conventional research strategies are time-consuming and costly. Drug repurposing and nanotechnologies offer promising approaches for improving the delivery and efficacy of active substances.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)