Intranasal delivery of therapeutic proteins for neurological diseases

Filamentous Bacteriophage as a Novel Therapeutic Tool for Alzheimer's Disease Treatment

(2017) Beka Solomon   JOURNAL OF ALZHEIMERS DISEASE

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Delivery of NGF to the Brain: Intranasal versus Ocular Administration in Anti-NGF Transgenic Mice

(2017) Simona Capsoni et al.   JOURNAL OF ALZHEIMERS DISEASE

Intranasal Drug Delivery: How, Why and What for?

(2016) Anaísa Pires et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Taking Pain Out of NGF: A “Painless” NGF Mutant, Linked to Hereditary Sensory Autonomic Neuropathy Type V, with Full Neurotrophic Activity

(2011) Simona Capsoni et al.   PLoS One

Adjunctive Intranasal Oxytocin Reduces Symptoms in Schizophrenia Patients

(2010) David Feifel et al.   BIOLOGICAL PSYCHIATRY

Intranasal sumatriptan powder delivered by a novel breath-actuated bi-directional device for the acute treatment of migraine: A randomised, placebo-controlled study

(2010) PG Djupesland et al.   CEPHALALGIA

Oxytocin Enhances Amygdala-Dependent, Socially Reinforced Learning and Emotional Empathy in Humans

(2010) R. Hurlemann et al.   JOURNAL OF NEUROSCIENCE

Ciliary Neurotrophic Factor Cell-Based Delivery Prevents Synaptic Impairment and Improves Memory in Mouse Models of Alzheimer's Disease

(2010) P. Garcia et al.   JOURNAL OF NEUROSCIENCE

Can Alzheimer disease be prevented by amyloid-β immunotherapy?

(2010) Cynthia A. Lemere et al.   Nature Reviews Neurology

Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS

(2010) Takeshi Nishijima et al.   NEURON

NAP (davunetide) enhances cognitive behavior in the STOP heterozygous mouse—A microtubule-deficient model of schizophrenia

(2010) Avia Merenlender-Wagner et al.   PEPTIDES

Liposome-siRNA-Peptide Complexes Cross the Blood-Brain Barrier and Significantly Decrease PrPC on Neuronal Cells and PrPRES in Infected Cell Cultures

(2010) Bruce Pulford et al.   PLoS One

The Peptide That Binds

(2010) Kai MacDonald et al.   HARVARD REVIEW OF PSYCHIATRY

In vitro receptor binding properties of a “painless” NGF mutein, linked to hereditary sensory autonomic neuropathy type V

(2009) Sonia Covaceuszach et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intranasal Oxytocin Improves Emotion Recognition for Youth with Autism Spectrum Disorders

(2009) Adam J. Guastella et al.   BIOLOGICAL PSYCHIATRY

Development of a Non Invasive NGF-Based Therapy for Alzheimers Disease

(2009) Sonia Covaceuszach et al.   Current Alzheimer Research

Intranasal delivery of cells to the brain

(2009) Lusine Danielyan et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Nanoparticles for direct nose-to-brain delivery of drugs

(2009) Alpesh Mistry et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS

(2009) Sandra R. Alcalá-Barraza et al.   JOURNAL OF DRUG TARGETING

Direct in Vivo Intracellular Selection of Conformation-sensitive Antibody Domains Targeting Alzheimer's Amyloid-β Oligomers

(2009) Giovanni Meli et al.   JOURNAL OF MOLECULAR BIOLOGY

Intranasal delivery of ESBA105, a TNF-alpha-inhibitory scFv antibody fragment to the brain

(2009) Esther Furrer et al.   JOURNAL OF NEUROIMMUNOLOGY

Delivery of Nerve Growth Factor to Brain Via Intranasal Administration and Enhancement of Brain Uptake

(2009) Siva Ram Kiran Vaka et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Brain delivery of proteins by the intranasal route of administration: A comparison of cationic liposomes versus aqueous solution formulations

(2009) Mattia M. Migliore et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Intranasal delivery to the central nervous system: Mechanisms and experimental considerations

(2009) Shyeilla V. Dhuria et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Intranasal Administration of PEGylated Transforming Growth Factor-α Improves Behavioral Deficits in a Chronic Stroke Model

(2009) Magda Guerra-Crespo et al.   Journal of Stroke & Cerebrovascular Diseases

Nasal Delivery of High Molecular Weight Drugs

(2009) Yıldız Ozsoy et al.   MOLECULES

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Oxytocin: The Great Facilitator of Life

(2009) Heon-Jin Lee et al.   PROGRESS IN NEUROBIOLOGY

New Generation of Hybrid Poly/Oligosaccharide Nanoparticles as Carriers for the Nasal Delivery of Macromolecules

(2008) Desirée Teijeiro-Osorio et al.   BIOMACROMOLECULES

New insights into brain BDNF function in normal aging and Alzheimer disease

(2008) Lucia Tapia-Arancibia et al.   BRAIN RESEARCH REVIEWS

Monoclonal Antibodies as Innovative Therapeutics

(2008) Janice Reichert   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Male Anorgasmia Treated with Oxytocin

(2008) Waguih William IsHak et al.   Journal of Sexual Medicine

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Nasal administration of cholera toxin B subunit–nerve growth factor improves the space learning and memory abilities in β-amyloid protein25-35-induced amnesic mice

(2008) Q. Zhang et al.   NEUROSCIENCE

Delivery of interferon-β to the monkey nervous system following intranasal administration

(2008) R.G. Thorne et al.   NEUROSCIENCE

Intranasal administration delivers peptoids to the rat central nervous system

(2008) Tinna M. Ross et al.   NEUROSCIENCE LETTERS

Identification of nose-to-brain homing peptide through phage display

(2008) Xiao-Mei Wan et al.   PEPTIDES

Evaluation of Direct Transport Pathways of Glycine Receptor Antagonists and an Angiotensin Antagonist from the Nasal Cavity to the Central Nervous System in the Rat Model

(2008) Stuart T. Charlton et al.   PHARMACEUTICAL RESEARCH

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY